Patents by Inventor William Toreki, III

William Toreki, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and devices for controlled release of active ingredients
    Patent number: 6306422
    Abstract: A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. In one embodiment, the polymer matrix swells when the environment reaches pH 8.5, releasing the active agent. A polymer of hydrophobic and weakly acidic comonomers is disclosed for use in the controlled release system. In another embodiment, weakly basic comonomers are used and the active agent is released as the pH drops. Further disclosed is a specific embodiment in which the controlled release system may be used. The pH-sensitive polymer is coated onto a latex catheter used in ureteral catheterization. A common problem with catheterized patients is the infection of the urinary tract with urease-producing bacteria. In addition to the irritation caused by the presence of the bacteria, urease produced by these bacteria degrade urea in the urine, forming carbon dioxide and ammonia. The ammonia causes an increase in the pH of the urine.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: October 23, 2001
    Assignee: CApHCO, Inc.
    Inventors: Christopher D. Batich, Marc S. Cohen, Kirk Foster, William Toreki, III
  • Injectable bio-active glass in a dextran suspension
    Patent number: 6190684
    Abstract: The present invention relates to injectable suspensions of bio-active glass and dextran or a dextran derivative for the repair of soft tissue or hard bone in mammals, especially humans. In one embodiment, the dextran derivatives include free radical polymerizable groups, which can be polymerized following injection into a patient.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: February 20, 2001
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Larry L. Hench, Jon K. West, Guy LaTorre, June Wilson, William Toreki, III, Christopher Batich
  • Moldable bioactive compositions
    Patent number: 6051247
    Abstract: A moldable bioactive composition including (a) bioactive particles of bioactive glass, glass-ceramics, calcium phosphates, calcium apatites, or mixtures thereof; and (b) a biodegradable polysaccharide carrier including a polysaccharide with an average molecular weight of about 200,000-5,000,000.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: April 18, 2000
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Larry L. Hench, Guy LaTorre, Jon K. West, June Wilson, William Toreki, III, Christopher Batich
  • Injectable bio-active glass in a dextran suspension
    Patent number: 5840290
    Abstract: The present invention relates to novel injectable aqueous suspensions of bio-active glass and dextrans for the repair of soft tissue or hard bone of mammals, especially in humans.
    Type: Grant
    Filed: May 30, 1996
    Date of Patent: November 24, 1998
    Assignee: University of Florida Research Foundation
    Inventors: Larry L. Hench, Jon K. West, Guy LaTorre, June Wilson, William Toreki, III, Christopher Batich
  • Compositions and devices for controlled release of active ingredients
    Patent number: 5788687
    Abstract: A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. In one embodiment, the polymer matrix swells when the environment reaches pH 8.5, releasing the active agent. A polymer of hydrophobic and weakly acidic comonomers is disclosed for use in the controlled release system. In another embodiment, weakly basic comonomers are used and the active agent is released as the pH drops. Further disclosed is a specific embodiment in which the controlled release system may be used. The pH-sensitive polymer is coated onto a latex catheter used in ureteral catheterization. A common problem with catheterized patients is the infection of the urinary tract with urease-producing bacteria. In addition to the irritation caused by the presence of the bacteria, urease produced by these bacteria degrade urea in the urine, forming carbon dioxide and ammonia. The ammonia causes an increase in the pH of the urine.
    Type: Grant
    Filed: July 31, 1995
    Date of Patent: August 4, 1998
    Assignee: CApHCO, Inc
    Inventors: Christopher D. Batich, Marc S. Cohen, Kirk Foster, William Toreki, III