Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.

Abstract: A computer-based method is provided for monitoring bicycle range. The method includes retrieving powered bicycle range data and defining a remaining powered bicycle range at least partially based on the powered bicycle range data. The method then determines or acquires distance to destination data and defines a remaining distance to a destination at least partially based on the distance to destination data. The method then compares the powered bicycle range data or the remaining powered bicycle range to the distance to destination data or the remaining distance to the destination and generates a visualization comparing the powered bicycle range data to the distance to destination data. Also provided is a system for implementing the methods described.

Abstract: A method for identifying a completed lap at a device is disclosed. An example method includes retrieving or defining lap initiation data that can include an initiation location and an initiation orientation. The method also includes retrieving or defining a location variance threshold for the initiation location and an orientation variance threshold for the initiation orientation. The method further includes determining, by a position determining module of the device, a first location of the device associated with a first time. The method also includes determining, by an orientation determining module of the device, a first orientation of the device associated with the first time. The method also includes identifying a lap as completed upon determining that the first location of the device is within the location variance threshold of the initiation location and that the first orientation of the device is within the orientation variance threshold of the initiation orientation.

Abstract: A computer-based method is provided for providing analytical features at a navigation device. The method includes determining, by a position determining module of the navigation device, a first location of the navigation device associated with a first time. The method then proceeds to determine a second location of the navigation device associated with a second time and associates the first and second locations with coordinates on a first graph edge of a map, determines a travel direction based on a sequence of the locations, and determines a current location of the navigation device. An inferred path defining a travel path is then based on coordinates associated with the first and second locations, the travel direction, and the current location, and mapping data associated with the likely travel path is analyzed to identify a characteristic of interest of the likely travel path.