Patents by Inventor William V. Ruyle

William V. Ruyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
    Patent number: 4584294
    Abstract: The invention relates to fused tricyclic lactams and related compounds which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: November 7, 1984
    Date of Patent: April 22, 1986
    Assignee: Merck & Co., Inc.
    Inventor: William V. Ruyle
  • N-Terminal substituted oligopeptide converting enzyme inhibitors
    Patent number: 4483850
    Abstract: N-Terminal substituted oligopeptides are disclosed. The compounds are angiotensin converting enzyme inhibitors useful as antihypertensives.
    Type: Grant
    Filed: February 18, 1983
    Date of Patent: November 20, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William V. Ruyle
  • Inhibitor of dihydrofolate reductase
    Patent number: 4258045
    Abstract: A group of aryl-Z-alkoxy-5-benzylpyrimidines wherein Z is oxy, thio, imino, carbonyl, carbamoyl, sulfonyl, sulfinyl or sulfamoyl has been prepared from 2,4-diamino-5-benzylpyrimidine via alkylation with either an aryl-Z-alkyl halide or a substituted glycidyl ether. These compounds are potent dihydrofolate reductase (DHFR) inhibitors which are useful as antibacterial, anti-protozoal and antitumor agents.
    Type: Grant
    Filed: November 30, 1979
    Date of Patent: March 24, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Martin Poe, William V. Ruyle
  • Substituted dihydropyridine ureas
    Patent number: 4176187
    Abstract: Dihydropyridine ureas having antihypertensive activity are disclosed.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: November 27, 1979
    Assignee: Merck & Co., Inc.
    Inventors: William V. Ruyle, Michael H. Fisher
  • 1-Substituted phenyl-4(1H)-pyridinone hydrazones and composition therewith for treatment of coccidiosis
    Patent number: 4083984
    Abstract: Novel 1-substitutedphenyl-4(1H)-pyridinone hydrazones are prepared by reacting 1-substitutedphenyl-4(1H)-pyridinone hydrazone with substituted benzaldehydes. The novel hydrazones are useful as anticoccidial agents.
    Type: Grant
    Filed: July 8, 1977
    Date of Patent: April 11, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Michael H. Fisher, William V. Ruyle
  • 1-Substitutedphenyl-4(1H)-pyridinone hydrazones
    Patent number: 4073791
    Abstract: Novel 1-Substitutedphenyl-4(1H)-pyridinone hydrazones are prepared by reacting 1-substitutedpheny-4(1H)-pyridinone hydrazone with substituted benzaldehydes. The novel hydrazones are useful as anticoccidial agents.
    Type: Grant
    Filed: November 19, 1976
    Date of Patent: February 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Michael H. Fisher, William V. Ruyle
  • Phenyl benzoic acid compounds
    Patent number: 4044049
    Abstract: The invention relates to substituted 5-(phenyl)benzoic acid esters and non-toxic pharmaceutically accepted salts thereof and processes for their preparation. The substituted 5-(phenyl)benozic acids are useful as anti-inflammatory compounds. Also included are method of treating inflammation claims by administering these particular compounds to patients.
    Type: Grant
    Filed: October 8, 1971
    Date of Patent: August 23, 1977
    Assignee: Merck & Co., Inc.
    Inventors: William V. Ruyle, Lewis H. Sarett, Alexander R. Matzuk