Abstract: A method for forming a multi-component composite metallic tube, in particular, a bi-component metallic tube, comprises the steps of forming a coextrudable, multi-component billet including an inner component formed from a first metallic material, and an outer component formed from a second metallic material. Notably, explosive bonding is employed for bonding the first and second components to form a metallurgical bond at the interface thereof, thus forming the desired multi-component billet. The multi-component billet is subsequently heated, and coextruded to form a multi-component tubular structure, having a metallurgical bond at an interface between inner and outer layers of the composite metallic tube.

Abstract: A method for forming a multi-component composite metallic tube, in particular, a bi-component metallic tube, comprises the steps of forming an extrudable, multi-component billet including an inner component formed from a first metallic material, and an outer component formed from a second metallic material. Notably, explosive bonding is employed for bonding the first and second components to form a metallurgical bond at the interface thereof, thus forming the desired multi-component billet. The multi-component billet is subsequently heated, and extruded to form a multi-component tubular structure, having a metallurgical bond at an interface between inner and outer layers of the composite metallic tube.

Abstract: A filter module utilizing a nano-porous ceramic membrane is provided for various applications including, but not limited to, enhanced hemodialysis performance, the removal (or separation) of cryoprotectant from biological materials, the separation of blood components (e.g., plasmapheresis), and controlling the concentration of cells in a biological fluid solution.

Abstract: A dialyzer module utilizing a nano-porous ceramic membrane for enhanced hemodialysis performance, and a method for manufacturing the same, are provided. The dialyzer module may be utilized in an extracorporeal blood circuit together with pumps, monitors, and/or other components used for dialysis therapy. The one or more nano-porous ceramic tubes that serve as the hemodialysis membrane may comprise aluminum oxide (alumina) or titanium oxide (titania) tubes manufactured by the anodization of aluminum (Al) or titanium (Ti) tubes in an appropriate acid solution. The nano-porous ceramic tubes may be produced with a nano-porous wall structure having an average pore diameter of approximately five to ten nanometers (run).