Patents by Inventor William Vousden

William Vousden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 18,21-Didesoxymacbecin Derivatives for the Treatment of Cancer
    Publication number: 20110160175
    Abstract: The present invention relates to macbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds involving incorporation of non-natural starter units and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: November 9, 2007
    Publication date: June 30, 2011
    Inventors: Christine Martin, Ming Zhang, Nigel Coates, William Vousden, Steven Moss, Sabine Gaisser
  • Methods of Screening for Anti-Angiogenic Compounds
    Publication number: 20110027185
    Abstract: The present invention relates to methods of screening for agents that bind to FBP21. In particular the present invention provides a method of identifying anti-angiogenic agents by screening for agents which are able to bind to FBP21. Compounds identified using the methods and screens of the present invention are useful in the prevention and treatment of conditions associated with angiogenesis.
    Type: Application
    Filed: July 14, 2008
    Publication date: February 3, 2011
    Inventors: Barrie Wilkinson, Christine Martin, William Vousden, Steven Moss
  • 18 ,21-Didesoxymacbecin Derivatives for the Treatment of Cancer
    Publication number: 20090253667
    Abstract: The present invention relates to 18,21-didesoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: May 9, 2007
    Publication date: October 8, 2009
    Inventors: Christine Martin, Ming Zhang, Nigel Coates, William Vousden, Steven Moss, Sabine Gaisser
  • 15-O-Desmethylmacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies
    Publication number: 20090209507
    Abstract: The present invention relates to 15-O-desmethylmacbecin analogues according to the formula (IA) or (IB) herein, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); and R3 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: March 30, 2007
    Publication date: August 20, 2009
    Inventors: Sabine Gaisser, Christine Martin, Ming Zhang, Barrie Wilkinson, Nigel Coates, Mohammed Nur-E-Alam, William Vousden
  • Novel Compounds and Methods for Their Production
    Publication number: 20090117127
    Abstract: The present invention relates to 11-O-desmethylmacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: March 30, 2007
    Publication date: May 7, 2009
    Inventors: Sabine Gaisser, Christine Martin, Ming Zhang, Barrie Wilkinson, Lesley Sheehan, Nigel Coates, Mohammed Nur-E-Alam, William Vousden, Nikolaos Gaitatzis
  • Novel spinosyn-producing polyketide synthases
    Publication number: 20060040877
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 23, 2006
    Inventors: Lesley Burns, Paul Graupner, Paul Lewer, Christine Martin, William Vousden, Clive Waldron, Barrie Wilkinson