Patents by Inventor William W. Brey
William W. Brey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9274199Abstract: NMR probe coils designed to operate at two different frequencies, producing a strong and homogenous magnetic field at both the frequencies. This single coil, placed close to the sample, provides a method to optimize the NMR detection sensitivity of two different channels. In addition, the present invention describes a coil that generates a magnetic field that is parallel to the substrate of the coil as opposed to perpendicular as seen in the prior art. The present invention isolates coils from each other even when placed in close proximity to each other. A method to reduce the presence of electric field within the sample region is also considered. Further, the invention describes a method to adjust the radio-frequency tuning and coupling of the NMR probe coils.Type: GrantFiled: July 10, 2014Date of Patent: March 1, 2016Assignees: The Florida State University Research Foundation, Inc, University of Florida Research Foundation, IncorporatedInventors: William W. Brey, Arthur S. Edison, Vijaykumar Ramaswamy, Jerris Hooker
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Publication number: 20140320131Abstract: NMR probe coils designed to operate at two different frequencies, producing a strong and homogenous magnetic field at both the frequencies. This single coil, placed close to the sample, provides a method to optimize the NMR detection sensitivity of two different channels. In addition, the present invention describes a coil that generates a magnetic field that is parallel to the substrate of the coil as opposed to perpendicular as seen in the prior art. The present invention isolates coils from each other even when placed in close proximity to each other. A method to reduce the presence of electric field within the sample region is also considered. Further, the invention describes a method to adjust the radio-frequency tuning and coupling of the NMR probe coils.Type: ApplicationFiled: July 10, 2014Publication date: October 30, 2014Inventors: William W. Brey, Arthur S. Edison, Vijaykumar Ramaswamy, Jerris Hooker
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Patent number: 8779768Abstract: NMR probe coils designed to operate at two different frequencies, producing a strong and homogenous magnetic field at both the frequencies. This single coil, placed close to the sample, provides a method to optimize the NMR detection sensitivity of two different channels. In addition, the present invention describes a coil that generates a magnetic field that is parallel to the substrate of the coil as opposed to perpendicular as seen in the prior art. The present invention isolates coils from each other even when placed in close proximity to each other. A method to reduce the presence of electric field within the sample region is also considered. Further, the invention describes a method to adjust the radio-frequency tuning and coupling of the MAR probe coils.Type: GrantFiled: November 1, 2013Date of Patent: July 15, 2014Assignees: The Florida State University Research Foundation, Inc., University of Florida Research Foundation, IncorporatedInventors: William W. Brey, Arthur Edison, Vijaykumar Ramaswamy, Jerris Hooker
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Publication number: 20140057792Abstract: NMR probe coils designed to operate at two different frequencies, producing a strong and homogenous magnetic field at both the frequencies. This single coil, placed close to the sample, provides a method to optimize the NMR detection sensitivity of two different channels. In addition, the present invention describes a coil that generates a magnetic field that is parallel to the substrate of the coil as opposed to perpendicular as seen in the prior art. The present invention isolates coils from each other even when placed in close proximity to each other. A method to reduce the presence of electric field within the sample region is also considered. Further, the invention describes a method to adjust the radio-frequency tuning and coupling of the MAR probe coils.Type: ApplicationFiled: November 1, 2013Publication date: February 27, 2014Applicants: University of Florida Research Foundation, Incorporated, The Florida State University Research Foundation, Inc.Inventors: William W. Brey, Arthur Edison, Vijaykumar Ramaswamy, Jerris Hooker
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Publication number: 20130328564Abstract: The present invention describes NMR probe coils that are designed to operate at two different frequencies, producing a strong and homogenous magnetic field at both the frequencies. This single coil, placed close to the sample, provides a method to optimize the NMR detection sensitivity of two different channels. In addition, the present invention describes a coil that generates a magnetic field that is parallel to the substrate of the coil as opposed to perpendicular as seen in the prior art. The present invention isolates coils from each other even when placed in close proximity to each other. A method to reduce the presence of electric field within the sample region is also considered. Further, the invention describes a method to adjust the radio-frequency tuning and coupling of the NMR probe coils.Type: ApplicationFiled: June 12, 2013Publication date: December 12, 2013Inventors: William W. Brey, Arthur Edison, Vijaykumar Ramaswamy, Jerris Hooker
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Patent number: 7754438Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.Type: GrantFiled: February 5, 2009Date of Patent: July 13, 2010Assignee: The Florida State University Research Foundation, Inc.Inventors: Timothy Cross, William W. Brey, Alexej Smirnov, Eduard Y. Chekmenev
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Patent number: 7678546Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.Type: GrantFiled: October 1, 2007Date of Patent: March 16, 2010Assignee: The Florida State University Research Foundation, Inc.Inventors: Timothy Cross, William W. Brey, Alexej Smirnov, Eduard Y Chekmenev
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Patent number: 7674595Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.Type: GrantFiled: February 5, 2009Date of Patent: March 9, 2010Assignee: The Florida State University Research Foundation, Inc.Inventors: Timothy A. Cross, William W. Brey, Alexej Smirnov, Eduard Y. Chekmenev
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Patent number: 6751847Abstract: A detection coil for use in nuclear resonance magnetic (NMR) spectroscopy and a method of manufacture thereof. At least two film layers of material are deposited on an outer surface of a cylindrical tube of dielectric material. The layers are patterned to form a solenoid on the tube. At least one of the deposited materials is a conductor.Type: GrantFiled: November 6, 2000Date of Patent: June 22, 2004Assignee: FSU Research Foundation, Inc.Inventors: William W. Brey, Susan D. Allen
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Patent number: 5619140Abstract: A method of making a an NMR coil is provided. A coil is patterned of a film of a conductive material on a substrate. The coil mask is designed so that the resultant coil will have a lower resonant frequency than the desired frequency of the final coil. The coil is placed in an apparatus where it is exposed to increasing current, preferably within a magnetic field such as will be used during operation. The current is gradually increased and the coil observed for changes in its resonant frequency. When the coil is exposed to its operating current without further change in its resonant frequency, it is trimmed by removal of part of the capacitive element of the coil to the desired frequency.Type: GrantFiled: June 5, 1995Date of Patent: April 8, 1997Assignee: Conductus, Inc.Inventors: William W. Brey, Marie E. Johansson, Richard S. Withers
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Patent number: 5594342Abstract: The conductive material in an RF coil disposed in the polarizing field of an NMR apparatus in miminized and the current density at each point in the coil kept constant by providing an inductive element and a set of tapered, interidigtated capacitors having a uniform gap therebetween. The invention maximizes the current-carrying capacity of the coil.Type: GrantFiled: June 5, 1995Date of Patent: January 14, 1997Assignee: Conductus, Inc.Inventors: William W. Brey, Richard S. Withers
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Patent number: 5565778Abstract: A resonant coil for nuclear magnetic spectroscopy and microscopy is provided, in which the coil is in the form of nested, interrupted loops of a conductive material forming a distributed inductive element and having a plurality of capacitive elements with capacitance distributed over the periphery of the loops. The coil is preferably formed as a thin film of a superconductive material on an electrically nonconductive substrate.Type: GrantFiled: June 5, 1995Date of Patent: October 15, 1996Assignee: Conductus, Inc.Inventors: William W. Brey, Weston A. Anderson, Wai H. Wong, Luiz F. Fuks, Vincent Y. Kotsubo, Richard S. Withers