Patents by Inventor William W. Cruikshank

William W. Cruikshank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-16 antagonists
    Publication number: 20020147151
    Abstract: In accordance with the present invention, novel IL-16 antagonists, preferably peptides derived from CD4, have been isolated and synthesized. These peptides possess IL-16 antagonistic properties including the ability to selectively bind to IL-16 and inhibit IL-16-mediated biological activity. The peptides comprise specific portions of the native human CD4 receptor and variations thereof and therefore are non-immunogenic when administered to humans. The present invention also provides compositions containing at least one IL-16 antagonist peptide which can inhibit, suppress or cause the cessation of at least one IL-16-mediated biological activity in mammals, including humans.
    Type: Application
    Filed: August 15, 2001
    Publication date: October 10, 2002
    Inventors: David M. Center, William W. Cruikshank, Hardy Kornfeld
  • Lymphocyte chemoattractant factor
    Patent number: 6159463
    Abstract: Purified DNA encoding LCF and the recombinant proteins expressed from such DNA are disclosed. In addition, the invention provides methods for suppressing an LCF-CD4 interaction and screening candidate LCF agonists or antagonists. The invention also provides compositions and methods useful for stimulating proliferation of CD4+ T-cells in a mammal.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: December 12, 2000
    Assignee: Research Corporation Technologies, Inc.
    Inventors: David M. Center, William W. Cruikshank, Hardy Kornfeld
  • Lymphocyte chemoattractant factor and uses thereof
    Patent number: 5976522
    Abstract: Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: November 2, 1999
    Assignee: Research Corporation Technologies, Inc.
    Inventors: David M. Center, William W. Cruikshank, Hardy Kornfeld
  • Lymphocyte chemoattractant factor and uses thereof
    Patent number: 5965120
    Abstract: Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: October 12, 1999
    Assignee: Research Corporation Technologies, Inc.
    Inventors: David M. Center, William W. Cruikshank, Hardy Kornfeld
  • Lymphocyte chemoattractant factor and uses thereof
    Patent number: 5869263
    Abstract: Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: February 9, 1999
    Assignee: Research Corporation Technologies, Inc.
    Inventors: David M. Center, William W. Cruikshank, Hardy Kornfeld
  • DNA encoding lymphocyte chemoattractant factor (LCF) and uses thereof
    Patent number: 5807712
    Abstract: Purified DNA encoding lyphocyte chemoattractant factor (LCF) and the recombinant proteins expressed from such DNA are disclosed. In addition, the invention provides methods for suppressing an LCF-CD4 interaction and screening candidate LCF agonists or antagonists. The invention also provides compositions and methods useful for stimulating proliferation of CD4+ T-cells in a mammal.
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: September 15, 1998
    Assignee: Research Corporation Technologies, Inc.
    Inventors: David M. Center, William W. Cruikshank, Hardy Kornfeld
  • Lymphocyte chemoattractant factor and uses thereof
    Patent number: 5766866
    Abstract: Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: June 16, 1998
    Assignee: Research Corporation Technologies, Inc.
    Inventors: David M. Center, William W. Cruikshank, Hardy Kornfeld