Patents by Inventor William W. Lai
William W. Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12214047Abstract: Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and prodrugs and compositions thereof, for example, in treating cancer or other cell proliferative diseases. In vitro and in vivo methods of quantifying the expression of FAP in a biopsy sample and a mammal, respectively, are also disclosed.Type: GrantFiled: June 15, 2021Date of Patent: February 4, 2025Assignee: Trustees of Tufts CollegeInventors: William W. Bachovchin, Hung-sen Lai, Sarah E. Poplawski
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Patent number: 9773621Abstract: An apparatus and method for the uniform dispersion of nano scaled redox particles in a conductive fiber including, combining at least one nano sized redox capable material having metal oxides and/or metals, at least one conductive binder, and at least one solvent to form electrically conductive metal imbedded fiber(s) by fiber spinning and the conductive polymeric binder having a molecular weight greater than 20,000 Daltons, and coating a substrate with the electrically conductive fiber(s) to form an active layer substrate complex having a conductivity greater than 0.05 S/cm.Type: GrantFiled: January 24, 2017Date of Patent: September 26, 2017Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Alfred J. Baca, John D. Stenger-Smith, Heather Meylemans
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Patent number: 9670317Abstract: A material that can be used either as a standalone or coating additive that would both repel water and resist corrosion would greatly benefit the Navy. A method of making hydrophobic polymer, including combining a perylene derived monomer with a bisphenol derived monomer to produce a polymer mixture, and condensing said polymer mixture to produce a hydrophobic polymer.Type: GrantFiled: March 29, 2016Date of Patent: June 6, 2017Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Benjamin G. Harvey, Alfred J. Baca, Heather Meylemans
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Patent number: 9666380Abstract: An apparatus and method for the uniform dispersion of nano scaled redox particles in a conductive fiber including, combining at least one nano sized redox capable material having metal oxides and/or metals, at least one conductive binder, and at least one solvent to form electrically conductive metal imbedded fiber(s) by fiber spinning and the conductive polymeric binder having a molecular weight greater than 20,000 Daltons, and coating a substrate with the electrically conductive fiber(s) to form an active layer/substrate complex having a conductivity greater than 0.05 S/cm.Type: GrantFiled: December 19, 2013Date of Patent: May 30, 2017Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Alfred J. Baca, John D. Stenger-Smith, Heather Meylemans
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Patent number: 9627622Abstract: A method for making electronic devices based on derivatized ladder polymer (Pz-BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.Type: GrantFiled: April 29, 2016Date of Patent: April 18, 2017Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Alfred J. Baca
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Patent number: 9558892Abstract: A method for making electronic devices based on derivatized ladder polymer poly(benzo-isimidazobenzophenanthroline) (BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.Type: GrantFiled: February 9, 2016Date of Patent: January 31, 2017Assignee: The United States of America as Represented by the Secretary of the NavyInventors: Alfred J. Baca, William W. Lai
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Patent number: 9435912Abstract: A wholly organic coating consisting of one or more layers of Py-BBL that is transparent in the IR region of the spectrum which is also thermally and oxdatively stable. This is coated onto IR transparent windows, domes and or optical lenses, for enhanced IR and signal filtering.Type: GrantFiled: November 15, 2012Date of Patent: September 6, 2016Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Lee R. Cambrea, Alfred J. Baca
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Patent number: 9379328Abstract: A method for making electronic devices based on derivatized ladder polymer poly(benzo-isimidazobenzophenanthroline) (BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.Type: GrantFiled: February 9, 2016Date of Patent: June 28, 2016Assignee: The United States of America as Represented by the Secretary of the NavyInventors: Alfred J. Baca, William W. Lai
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Patent number: 9356240Abstract: A method for making electronic devices based on derivatized ladder polymer (Pz-BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.Type: GrantFiled: November 2, 2012Date of Patent: May 31, 2016Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Alfred J. Baca
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Patent number: 9309440Abstract: A process used to cast films including; mixing Pyr-BBL and a room temperature molten salt from a range of about 35:65 weight ratio, dissolving the mixture in about 1% methanesulfonic acid to produce a Pyr-BBL solution, drop casting the solution onto glass or gold coated glass at 140° C. in air and heating for about 2 hours to produce films, drying the films in a vacuum oven at about 100° C. for at least 24 hours under dynamic vacuum, and rinsing the films to remove residual ionic liquid.Type: GrantFiled: May 12, 2015Date of Patent: April 12, 2016Assignee: The United States of America as Represented by the Secretary of the NavyInventors: John D Stenger-Smith, William W. Lai, David Irvin, Jennifer Irvin
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Patent number: 9293267Abstract: A method for making electronic devices based on derivatized ladder polymer poly(benzo-isimidazobenzophenanthroline) (BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.Type: GrantFiled: January 7, 2015Date of Patent: March 22, 2016Assignee: The United States of America as Represented by the Secretary of the NavyInventors: Alfred J Baca, William W Lai
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Patent number: 9068043Abstract: A process used to cast films including; mixing Pyr-BBL and a room temperature molten salt from a range of about 35:65 weight ratio, dissolving the mixture in about 1% methanesulfonic acid to produce a Pyr-BBL solution, drop casting the solution onto glass or gold coated glass at 140° C. in air and heating for about 2 hours to produce films, drying the films in a vacuum oven at about 100° C. for at least 24 hours under dynamic vacuum, and rinsing the films to remove residual ionic liquid.Type: GrantFiled: January 14, 2015Date of Patent: June 30, 2015Assignee: The United States of America as Represented by the Secretary of the NavyInventors: John D Stenger-Smith, William W Lai, David Irvin, Jennifer Irvin
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Patent number: 9048761Abstract: An energy harvesting device using auxetic materials includes a first auxetic conductive electrode layer. A second auxetic conductive electrode layer is associated with the first auxetic conductive electrode layer. The auxetic conductive electrode layers have negative Poisson ratios. At least one dielectric elastomer layer is associated in layered orientation between the first and second auxetic conductive electrode layers.Type: GrantFiled: July 19, 2012Date of Patent: June 2, 2015Assignee: The United States of America as Represented by the Secretary of the NavyInventors: M. Joseph Roberts, Alfred J. Baca, William W. Lai, Lawrence C. Baldwin, Michael T. Owens
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Patent number: 9030079Abstract: An energy harvesting device using auxetic materials includes a first auxetic conductive electrode layer. A second auxetic conductive electrode layer is associated with the first auxetic conductive electrode layer. The auxetic conductive electrode layers have negative Poisson ratios. At least one dielectric elastomer layer is associated in layered orientation between the first and second auxetic conductive electrode layers.Type: GrantFiled: July 19, 2012Date of Patent: May 12, 2015Assignee: The United States of America as Represented by the Secretary of the NavyInventors: M. Joseph Roberts, Alfred J. Baca, William W. Lai, Lawrence C. Baldwin, Michael T. Owens
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Patent number: 9017794Abstract: A plasmonic array and methods of fabricating having a substrate, a layer of elastomeric material cured in nanowell or nanopost features, a fluorescent layer, and a plasmonic metal layer on top.Type: GrantFiled: November 15, 2012Date of Patent: April 28, 2015Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Lee R. Cambrea, Alfred J. Baca
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Patent number: 8993713Abstract: A n-type ladder copolymer including, a n-type ladder copolymer formed with alternating perylene and pyridine units having chemical structure A having two end groups, where perylene units having at least one solubilizing group attaching at position(s) 1, 6, 7, and/or 12, where R1, R2, R3, and R4 solubilizing group(s) are each independently selected from the group consisting of aryl, alkyl aryl, alkoxy aryl, and aryloxy aryl, and where n repeat units ranging from about 4 to about 400Type: GrantFiled: May 16, 2013Date of Patent: March 31, 2015Assignee: The United States of America as represented by the Secretary of the NavyInventors: William W. Lai, Alfred Baca
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Patent number: 8951828Abstract: A method for making electronic devices based on derivatized ladder polymer poly(benzo-isimidazobenzophenanthroline) (BBL) including photovoltaic modules and simple thin film transistors in planar and mechanically flexible and stretchable constructs.Type: GrantFiled: November 2, 2012Date of Patent: February 10, 2015Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Alfred J. Baca
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Patent number: 8692397Abstract: A mechanism for the conversion of vertical motion to translational or rotational motion includes a substrate, at least one permanent magnet, at least one coil of wire, at least one inelastic material, at least one elastic material, and at least one pivot point. The coil of wire is a solenoid.Type: GrantFiled: December 26, 2012Date of Patent: April 8, 2014Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Alfred J. Baca, M. Joseph Roberts, Lawrence C. Baldwin, Michael T. Owens
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Patent number: 8692396Abstract: A hybrid system for harvesting magnetic and electrical energy includes a substrate, at least one permanent magnet, and at least one coil of wire equal in number to the permanent magnet. Each permanent magnet is configured to fit in the substrate. Each coil of wire is configured to fit circumferentially around a respective permanent magnet. Each coil of wire is configured to fit in the substrate.Type: GrantFiled: June 13, 2012Date of Patent: April 8, 2014Assignee: The United States of America as Represented by the Secretary of the NavyInventors: William W. Lai, Alfred J. Baca, M. Joseph Roberts, Lawrence C. Baldwin, Michael T. Owens
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Patent number: 8680698Abstract: A self-contained mechanism for the conversion of vertical motion to rotational/transitional motion includes a substrate having at least one interior compartment, at least one nonconductive tube, at least one permanent magnet, and at least one coil of wire. The coil of wire is a solenoid. The nonconductive tube, permanent magnet, and solenoid are configured to fit in the interior compartment.Type: GrantFiled: December 26, 2012Date of Patent: March 25, 2014Assignee: The United States of America as represented by the Secretary of the NavyInventors: William W. Lai, Alfred J. Baca