Abstract: A server for detecting anomalies associated with users accessing a network is caused to receive a dataset including static data and dynamic data. The static data includes location data of resources associated with the network and user data, and the dynamic data includes user access events. The server is further caused to detect, with a plurality of unsupervised machine learning models, an anomaly associated with a user accessing the network based on the static data and the dynamic data, determine whether the detected anomaly is critical, and in response to determining the detected anomaly is critical, generate and transmit a security alert specific to the detected anomaly to a security operation center. Other example servers, systems, apparatuses, methods, and non-transitory computer readable medium for detecting anomalies associated with users accessing a network are also disclosed.

Abstract: A server for detecting anomalies associated with users accessing a network is caused to receive a dataset including static data and dynamic data. The static data includes location data of resources associated with the network and user data, and the dynamic data includes user access events. The server is further caused to detect, with a plurality of unsupervised machine learning models, an anomaly associated with a user accessing the network based on the static data and the dynamic data, determine whether the detected anomaly is critical, and in response to determining the detected anomaly is critical, generate and transmit a security alert specific to the detected anomaly to a security operation center. Other example servers, systems, apparatuses, methods, and non-transitory computer readable medium for detecting anomalies associated with users accessing a network are also disclosed.

Abstract: The present disclosure generally relates to methods and compositions used for modulating or controlling gene expression involving sequence targeting, genome perturbation or gene-editing, that relate to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof. In some embodiments, compositions comprising a catalytically inactive Cas9 (dCas9) fusion protein and methods for modulating expression of a gene of interest are disclosed.

Abstract: A wingless vertical take-off and landing (VTOL) vehicle has a main body including airfoil sections on either side of a central module in which a load may be carried. Articulated forward thrust systems are mounted on a leading edge of the main body and lateral members are located on either side of the main body and form winglets. At least one rear vertical-thrust system may also be provided and, in one embodiment, is mounted in an aperture aft of the central module. The forward thrust systems transition between a vertical flight configuration and a horizontal flight configuration. The lateral members are configured as both vortex-damping members and also to channel backwash from the forward thrust systems over the airfoil formed by the main body.

Abstract: The present disclosure relates to a method of treating mild to moderate Alzheimer's disease comprising administering to a subject with Alzheimer's disease ATH-1017.

Abstract: A server for detecting fraudulent user authentication requests is caused to receive, by a plurality of machine learning (ML) models, a dataset including user data specific to a user logging into an account during an authentication request and device data specific to a computing device used by the user to log into the account during the authentication request, generate, with the plurality of ML models configured to detect a plurality of different fraud types, a response based on the dataset, the response including at least one ML score representing a probability of at least one of the plurality of different fraud types occurring during the authentication request, and generate an authentication denial response for the authentication request based on the ML score and a threshold. Other example servers, systems, apparatuses, methods, and non-transitory computer readable medium for detecting fraudulent user authentication requests are also disclosed.

Abstract: Systems, methods, and machine-readable media may facilitate one or a combination of the following. A software change operation within a deployment pipeline for testing and deploying a software change to a production computing service may be processed. The software change operation may be identified as corresponding to a software change with the deployment pipeline, where the software change may be identified as being configured to make a pipeline change to a configuration of the deployment pipeline itself. Responsive to the identifying, a regression suite configured to run a plurality of test applications on the deployment pipeline to test the deployment pipeline with respect to the software change may be invoked, and the plurality of test applications may be run with the software change. The running the plurality of test applications may include simulating pipeline runs with a plurality of use cases.

Abstract: A motion planner of a computer system of a primary agent, e.g., an autonomous vehicle, uses reconfigurable collision detection architecture hardware to perform a collision assessment on a planning graph for the primary agent prior to execution of a motion plan. For edges on the planning graph, which represent transitions in states of the primary agent, the system sets a probability of collision with another agent, e.g., a dynamic object, in the environment based at least in part on the collision assessment. Depending on whether the goal of the primary agent is to avoid or collide with a particular dynamic object in the environment, the system then performs an optimization to identify a path in the resulting planning graph with either a relatively low or relatively high potential of a collision with the particular dynamic object. The system then causes the actuator system of the primary agent to implement a motion plan with the applicable identified path based at least in part on the optimization.

Abstract: Systems, methods, and machine-readable media may facilitate one or a combination of the following. A software change operation within a deployment pipeline for testing and deploying a software change to a production computing service may be processed. The software change operation may be identified as corresponding to a software change with the deployment pipeline, where the software change may be identified as being configured to make a pipeline change to a configuration of the deployment pipeline itself. Responsive to the identifying, a regression suite configured to run a plurality of test applications on the deployment pipeline to test the deployment pipeline with respect to the software change may be invoked, and the plurality of test applications may be run with the software change. The running the plurality of test applications may include simulating pipeline runs with a plurality of use cases.

Abstract: A server for detecting anomalies associated with users accessing a network is caused to receive a dataset including static data and dynamic data. The static data includes location data of resources associated with the network and user data, and the dynamic data includes user access events. The server is further caused to detect, with a plurality of unsupervised machine learning models, an anomaly associated with a user accessing the network based on the static data and the dynamic data, determine whether the detected anomaly is critical, and in response to determining the detected anomaly is critical, generate and transmit a security alert specific to the detected anomaly to a security operation center. Other example servers, systems, apparatuses, methods, and non-transitory computer readable medium for detecting anomalies associated with users accessing a network are also disclosed.

Abstract: A wingless vertical take-off and landing (VTOL) vehicle has a main body including airfoil sections on either side of a central module in which a load may be carried. Articulated forward thrust systems are mounted on a leading edge of the main body and lateral members are located on either side of the main body and form winglets. At least one rear vertical-thrust system may also be provided and, in one embodiment, is mounted in an aperture aft of the central module. The forward thrust systems transition between a vertical flight configuration and a horizontal flight configuration. The lateral members are configured as both vortex-damping members and also to channel backwash from the forward thrust systems over the airfoil formed by the main body.

Abstract: An ultrasound system for imaging a target is provided. The system includes a plurality of transducer elements; at least one transmitter configured to excite at least one of the transducer elements to emit ultrasound energy to the target; a plurality of samplers configured to sample echo signals received by at least some of the plurality of transducer elements, the echo signals comprising acoustic echoes received from the target responsive to the ultrasound energy; a coherence calculator configured to calculate a plurality of coherence values, each of the coherence values corresponding to a measure of similarity between at least two sample echo signals; an estimator configured to estimate a coherence contribution estimate, the coherence contribution estimate comprising an estimate of a contribution of at least one coherence model to the plurality of coherence values.

Abstract: Systems, methods, and machine-readable media may facilitate one or a combination of the following. A software change operation within a deployment pipeline for testing and deploying a software change to a production computing service may be processed. The software change operation may be identified as corresponding to a software change with the deployment pipeline, where the software change may be identified as being configured to make a pipeline change to a configuration of the deployment pipeline itself. Responsive to the identifying, a regression suite configured to run a plurality of test applications on the deployment pipeline to test the deployment pipeline with respect to the software change may be invoked, and the plurality of test applications may be run with the software change. The running the plurality of test applications may include simulating pipeline runs with a plurality of use cases.

Abstract: The present disclosure relates to a method of treating Parkinson's Disease and/or Lewy body disease or disorder(s), including Parkinson's disease dementia and dementia with Lewy bodies, comprising administering to a subject ATH-1017.

Abstract: The present disclosure relates to a method of treating Parkinson's Disease and/or Lewy body disease or disorder(s), including Parkinson's disease dementia and dementia with Lewy bodies, comprising administering to a subject ATH-1017.

Abstract: A wingless vertical take-off and landing (VTOL) vehicle has a main body including airfoil sections on either side of a central module in which a load may be carried. Articulated forward thrust systems are mounted on a leading edge of the main body and lateral members are located on either side of the main body and form winglets. At least one rear vertical-thrust system may also be provided and, in one embodiment, is mounted in an aperture aft of the central module. The forward thrust systems transition between a vertical flight configuration and a horizontal flight configuration. The lateral members are configured as both vortex-damping members and also to channel backwash from the forward thrust systems over the airfoil formed by the main body.

Abstract: A motion planner of an autonomous vehicle's computer system uses reconfigurable collision detection architecture hardware to perform a collision assessment on a planning graph for the vehicle prior to execution of a motion plan. For edges on the planning graph, which represent transitions in states of the vehicle, the system sets a probability of collision with a dynamic object in the environment based at least in part on the collision assessment. Depending on whether the goal of the vehicle is to avoid or collide with a particular dynamic object in the environment, the system then performs an optimization to identify a path in the resulting planning graph with either a relatively high or relatively low potential of a collision with the particular dynamic object. The system then causes the actuator system of the vehicle to implement a motion plan with the applicable identified path based at least in part on the optimization.

Abstract: The fifth wheel trailer light testing device is a maintenance device. The fifth wheel trailer light testing device is adapted for use with a trailer. The fifth wheel trailer light testing device comprises the plurality of trailer lights, a plurality of flashing circuits, a plurality of isolation diodes, a plurality of switches, and a wiring harness connector. The plurality of trailer lights, the plurality of flashing circuits, the plurality of isolation diodes, the plurality of switches, and the wiring harness connector are electrically interconnected. The fifth wheel trailer light testing device electrically tests a plurality of trailer lights. The fifth wheel trailer light testing device illuminates the plurality of trailer lights to be sure that each trailer light selected from the plurality of trailer lights is operating. The fifth wheel trailer light testing device is further configured to simultaneously flash all of the plurality of trailer lights.

Abstract: A wingless vertical take-off and landing (VTOL) vehicle has a main body including airfoil sections on either side of a central module in which a load may be carried. Articulated forward thrust systems are mounted on a leading edge of the main body and lateral members are located on either side of the main body and form winglets. At least one rear vertical-thrust system may also be provided and, in one embodiment, is mounted in an aperture aft of the central module. The forward thrust systems transition between a vertical flight configuration and a horizontal flight configuration. The lateral members are configured as both vortex-damping members and also to channel backwash from the forward thrust systems over the airfoil formed by the main body.

Abstract: The present disclosure relates to a method of treating mild to moderate Alzheimer's disease comprising administering to a subject with Alzheimer's disease ATH-1017.