Abstract: The present disclosure generally relates to methods and compositions used for modulating or controlling gene expression involving sequence targeting, genome perturbation or gene-editing, that relate to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof. In some embodiments, compositions comprising a catalytically inactive Cas9 (dCas9) fusion protein and methods for modulating expression of a gene of interest are disclosed.

Abstract: A workflow system may include an interface configured to receive a request, wherein the request includes one or more of a certification request, an audit request, a sustainability report request, or a comparative analysis request. The system may include a controller coupled with the interface and configured to process the request, the controller including: a data collection module configured to determine one or more entities to contact based on the request, to generate a targeted data collection request, to transmit the targeted data collection request, and to collect data; a data modeling module configured to input the data collected into a data model; and a report module configured to receive the data collected from the one or more entities and generate a report based on at least one of the data model or the data collected from the one or more entities.

Abstract: A wingless vertical take-off and landing (VTOL) vehicle has a main body including airfoil sections on either side of a central module in which a load may be carried. Articulated forward thrust systems are mounted on a leading edge of the main body and lateral members are located on either side of the main body and form winglets. At least one rear vertical-thrust system may also be provided and, in one embodiment, is mounted in an aperture aft of the central module. The forward thrust systems transition between a vertical flight configuration and a horizontal flight configuration. The lateral members are configured as both vortex-damping members and also to channel backwash from the forward thrust systems over the airfoil formed by the main body.

Abstract: The present disclosure relates to a method of treating mild to moderate Alzheimer's disease comprising administering to a subject with Alzheimer's disease ATH-1017.

Abstract: There is provided a method of sending a content stream, comprising retrieving a sender framework associated with the at least one attribute, wherein the sender framework defines an arrangement of the plurality of tracks to be included in an output content stream. The output content stream is defined according to the sender framework. There is also provided a method of outputting a content stream on a user device, comprising receiving a content stream as defined by a sender framework, retrieving a user framework associated with the user electronic device, wherein the user framework defines at least one predetermined setting or instruction to be applied to the content stream, and applying the user framework to the content stream to update the content stream. The method may also include providing viewer engagement information and updating the sender framework in response to the viewer engagement information received.

Abstract: A server for detecting fraudulent user authentication requests is caused to receive, by a plurality of machine learning (ML) models, a dataset including user data specific to a user logging into an account during an authentication request and device data specific to a computing device used by the user to log into the account during the authentication request, generate, with the plurality of ML models configured to detect a plurality of different fraud types, a response based on the dataset, the response including at least one ML score representing a probability of at least one of the plurality of different fraud types occurring during the authentication request, and generate an authentication denial response for the authentication request based on the ML score and a threshold. Other example servers, systems, apparatuses, methods, and non-transitory computer readable medium for detecting fraudulent user authentication requests are also disclosed.

Abstract: There is provided a method of providing a custom manifest for a content stream to a user electronic device, the method comprising receiving a request for a manifest file, generating a custom manifest, wherein the custom manifest defines a personalised version of the content stream, and sending the custom manifest to the user electronic device. The method further comprises providing an updated custom manifest file based on a received updated request. There is also provided a method of outputting a content stream on a user electronic device, the method comprising sending a request for a manifest file, receiving a custom manifest file, and outputting a personalised version of the content stream as defined in the custom manifest file. The method further comprises sending an updated request for a custom manifest associated with the content stream, and receiving an updated custom manifest.

Abstract: A computer-implemented method of interacting with a video game system comprising a user input device, the method comprising: determining movement of a user using a sensor; predicting a future actuation of the user input device based on the determined movement, wherein the actuation triggers a game event; outputting an effect based on the predicted actuation of the user input device. This provides accurate, pre-emptive effects and improves the interaction between a video game system and a user.

Abstract: Systems, methods, and machine-readable media may facilitate one or a combination of the following. A software change operation within a deployment pipeline for testing and deploying a software change to a production computing service may be processed. The software change operation may be identified as corresponding to a software change with the deployment pipeline, where the software change may be identified as being configured to make a pipeline change to a configuration of the deployment pipeline itself. Responsive to the identifying, a regression suite configured to run a plurality of test applications on the deployment pipeline to test the deployment pipeline with respect to the software change may be invoked, and the plurality of test applications may be run with the software change. The running the plurality of test applications may include simulating pipeline runs with a plurality of use cases.

Abstract: A processing device for generating a group of users for a first user to complete a given task in a video game, completion requiring one or more in-game characteristics, the processing device comprising: an identification unit configured to identify one or more requirements of the given task; a selection unit configured to select one or more other users from a plurality of other users, wherein a respective one of the other users is selected in dependence upon at least one of the requirements and one or more in-game characteristics associated with the respective other user; and a group generation unit configured to generate the group for the first user to complete the given task, the generated group comprising the first user and the one or more selected other users.

Abstract: A motion planner of a computer system of a primary agent, e.g., an autonomous vehicle, uses reconfigurable collision detection architecture hardware to perform a collision assessment on a planning graph for the primary agent prior to execution of a motion plan. For edges on the planning graph, which represent transitions in states of the primary agent, the system sets a probability of collision with another agent, e.g., a dynamic object, in the environment based at least in part on the collision assessment. Depending on whether the goal of the primary agent is to avoid or collide with a particular dynamic object in the environment, the system then performs an optimization to identify a path in the resulting planning graph with either a relatively low or relatively high potential of a collision with the particular dynamic object. The system then causes the actuator system of the primary agent to implement a motion plan with the applicable identified path based at least in part on the optimization.

Abstract: A computer-implemented method for outputting a sound effect during video game gameplay is disclosed. The method comprises the steps of: determining a sound effect to be output; retrieving a source sound and a sound-editing operator from a memory device, wherein the sound-editing operator comprises an edit that, when applied to the source sound, generates the sound effect to be output; applying the sound-editing operator to the source sound to generate the sound effect to be output; and outputting the sound effect.

Abstract: A display apparatus comprises an at least partially transparent display, the display configured to generate light to form an image for display to a user positioned in front of the display, and at least one of light-transmitting device or light-receiving device positioned behind the display, wherein the at least one of light-transmitting device or light-receiving device is configured to at least one of transmit or receive light through at least part of the display, wherein the at least one of light-transmitting device or light-receiving device comprises or forms part of an optical wireless communications (OWC) apparatus configured to at least one of transmit or receive the light through the at least part of the display.

Abstract: Systems, methods, and machine-readable media may facilitate one or a combination of the following. A software change operation within a deployment pipeline for testing and deploying a software change to a production computing service may be processed. The software change operation may be identified as corresponding to a software change with the deployment pipeline, where the software change may be identified as being configured to make a pipeline change to a configuration of the deployment pipeline itself. Responsive to the identifying, a regression suite configured to run a plurality of test applications on the deployment pipeline to test the deployment pipeline with respect to the software change may be invoked, and the plurality of test applications may be run with the software change. The running the plurality of test applications may include simulating pipeline runs with a plurality of use cases.

Abstract: A peer highlight generation apparatus comprises receiving circuitry configured to receive peer profile data associated with a user, wherein the peer profile data identifies one or more peer gaming profiles that are respectively associated with one or more peers, wherein each peer has participated with the user in one or more video game sessions; first generating circuitry configured to generate one or more candidate highlights of a given peer, wherein each candidate highlight comprises image data of one of the one or more video game sessions in which the user and the given peer participated together, wherein at least a part of each candidate highlight comprises image data of an in-game avatar of the given peer; selecting circuitry configured to select a highlight from among the one or more generated candidate highlights; and rendering circuitry configured to render, for display, a list of one or more of the peer gaming profiles, wherein the list comprises the peer gaming profile of the given peer, wherein the

Abstract: An optical wireless communication (OWC) unit for transmitting and/or receiving data installable in a further device comprises at least one transmitter device for transmitting modulated light comprising an OWC signal of said data and/or at least one receiver device for receiving modulated light comprising an OWC signal representative of said data, wherein the at least one receiver device comprises at least one detector. The OWC unit further comprises analogue electronic circuitry for processing electronic signals and at least one power connection and/or at least one data connection for connection to a power source and/or processing resource of the further device. The OWC unit is operable to provide OWC communication under control of said further device and/or so as to transmit data from/provide data to said further device. The OWC unit is for use in an OWC system having an analogue bandwidth greater than or equal to 80 MHz.

Abstract: A handheld video game controller includes one or more user-operable input elements, control circuitry to generate controller data indicative of operation of one or more of the user-operable input elements, and communication circuitry, where for a first communication mode, the communication circuitry is configured to transmit the controller data directly to a video game console as a destination device for the controller data, and where for a second communication mode, the communication circuitry is configured to transmit the controller data via a plurality of networked devices to a video game processing device as the destination device for the controller data.

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract: A server for detecting anomalies associated with users accessing a network is caused to receive a dataset including static data and dynamic data. The static data includes location data of resources associated with the network and user data, and the dynamic data includes user access events. The server is further caused to detect, with a plurality of unsupervised machine learning models, an anomaly associated with a user accessing the network based on the static data and the dynamic data, determine whether the detected anomaly is critical, and in response to determining the detected anomaly is critical, generate and transmit a security alert specific to the detected anomaly to a security operation center. Other example servers, systems, apparatuses, methods, and non-transitory computer readable medium for detecting anomalies associated with users accessing a network are also disclosed.

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein arr methods for making and using GDF15 molecules.