Abstract: A portable device for use in the application of simultaneous radial vibration, orbital motion and rotational or torsional oscillation to a person. The device includes: (1) a power unit for housing a power source to supply power to the apparatus; (2) a motor having an output shaft positioned within the power unit; (3) a stimulator for directly translating rotational energy into orbital motion, creating rotational or torsional oscillation, and producing random radial vibration; and (4) a flexible covering surrounding the device.

Abstract: A portable device for use in the application of simultaneous radial vibration, orbital motion and rotational or torsional oscillation to a person. The device includes: (1) a power unit for housing a power source to supply power to the apparatus; (2) a motor having an output shaft positioned within the power unit; (3) a stimulator for directly translating rotational energy into orbital motion, creating rotational or torsional oscillation, and producing random radial vibration; and (4) a flexible covering surrounding the device.

Abstract: The present invention is directed to methods for extending the duration of the therapeutic effect of a botulinum toxin in an animal. The methods involve the administration of a botulinum toxin, preferably botulinum toxin A, to treat a condition or disorder, and administration of an inhibitor of the protein tyrosine kinase pathway to an animal, such as a mammal, in particular a human, in an amount sufficient to extend the duration of the therapeutic effect of a botulinum toxin. The inhibitor of the protein tyrosine kinase pathway is preferably genistein or an analogue or prodrug thereof or a pharmaceutically acceptable salt of any of the foregoing.