Abstract: In mass spectrometry significant error is introduced during sample preparation (sample-to-sample error), during ion generation (ion suppression), and during ion transmission (ion transmission losses). We demonstrate the ability to correct for ion suppression and ion transmission losses, and that once corrected for ion losses, a sample-to-sample normalization of the analytical sample to the internal standard is possible. By normalizing to a standard sample the analytical sample becomes completely comparable to any similarly treated sample.

Abstract: A setting tool includes a housing having an initiator compartment to receive an initiator for initiating combustion of a combustible element, a combustion compartment to receive the combustible element, and a switch compartment to at least partially receive a switch circuit for activating the initiator, a piston configured to impart a setting force against the plug in response to combustion of the combustible element, and an interrupt flowpath configured to connect at least one of the combustion compartment and the initiator compartment with the switch compartment whereby combustion products that may be created in the initiator compartment or combustion compartment would be circulated from the at least one of the combustion compartment and the initiator compartment to the switch compartment to disconnect the switch circuit in response to the activation of the initiator charge.

Abstract: Apparatus for performing impedance measurements on a subject. The apparatus includes a first processing system for determining an impedance measurement procedure and determining instructions corresponding to the measurement procedure. A second processing system is provided for receiving the instructions, using the instructions to generate control signals, with the control signals being used to apply one or more signals to the subject. The second processing system then receives first data indicative of the one or more signals applied to the subject, second data indicative of one or more signals measured across the subject and performs at least preliminary processing of the first and second data to thereby allow impedance values to be determined.

Abstract: Ultrasound imaging is a non-invasive, non-radioactive, and low cost technology for diagnosis and identification of implantable medical devices in real time. Developing new ultrasound activated coatings is important to broaden the utility of in vivo marking by ultrasound imaging. Ultrasound responsive macro-phase segregated micro-composite thin films were developed to be coated on medical devices composed of multiple materials and with multiple shapes and varying surface area. The macro-phase segregated films having silica micro-shells in polycyanoacrylate produces strong color Doppler signals with the use of a standard clinical ultrasound transducer. Electron microscopy showed a macro-phase separation during slow curing of the cyanoacrylate adhesive, as air-filled silica micro-shells were driven to the surface of the film. The air sealed in the hollow space of the silica shells acted as an ultrasound contrast agent and echo decorrelation of air exposed to ultrasound waves produces color Doppler signals.

Abstract: Example embodiments involve a metrics collection system for collecting software usage metrics from one or more client devices at deployments. A computer, such as a server configured to execute the metrics collection system, collects software usage metrics (e.g., as a metrics submission from a client device) of the software product at the deployment, identifies a metrics type of the software usage metrics collected, assigns the software usage metrics to a metrics category, and calculates and updates a metrics score of the metrics category, based on the software usage metrics collected.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: Example embodiments involve a metrics collection system for collecting software usage metrics from one or more client devices at deployments. A computer, such as a server configured to execute the metrics collection system, collects software usage metrics (e.g., as a metrics submission from a client device) of the software product at the deployment, identifies a metrics type of the software usage metrics collected, assigns the software usage metrics to a metrics category, and calculates and updates a metrics score of the metrics category, based on the software usage metrics collected.

Abstract: A multi-tubing pinch valve assembly including a receiving space defined between a pinch protrusion and tubing contact body. The multi-tubing pinch valve assembly is moveable between a retracted state and an extended state. In the extended state, multiple tubes disposed in the receiving space are pinched, restricting flow therethrough. In the retracted state, multiple tubes are capable of being loaded into and/or out of the receiving space.

Abstract: Apparatus for performing impedance measurements on a subject. The apparatus includes a first processing system for determining an impedance measurement procedure and determining instructions corresponding to the measurement procedure. A second processing system is provided for receiving the instructions, using the instructions to generate control signals, with the control signals being used to apply one or more signals to the subject. The second processing system then receives first data indicative of the one or more signals applied to the subject, second data indicative of one or more signals measured across the subject and performs at least preliminary processing of the first and second data to thereby allow impedance values to be determined.

Abstract: Ambulatory modular infusion pump systems are provided, including a housing having a housing front and a housing back, a controller coupled to the housing front, and one or more pump modules disposed within the housing. Each pump module includes a door assembly including a door having a door securement, a channel housing, a cartridge gasket, at least one sensor, a plurality of pump fingers, a frame assembly and a motor. One or more button assemblies are disposed on the housing front, each button assembly having a button disposed adjacent a corresponding pump module and configured to release the door of the corresponding pump module when the button is moved to a release position. Methods of single handed operation of and configuration of ambulatory modular infusion pump systems are also provided.

Abstract: Prodrugs of colchicine, de-acetyl colchicine, colcemid, and nocodazole are provided as therapies for the treatment of diseases ameliorated by the inhibition of microtubule polymerization.

Abstract: An apparatus (104) and a method (800) for controlling steering of rear wheels (103) of a vehicle (100) are disclosed. The apparatus (104) comprises a control means (105) configured to receive a first signal indicative of a front wheel steering angle and a second signal indicative of a selected mode selected from at least a first mode and a second mode. The control means is also configured to determine a proposed rear wheel steering angle in dependence on the first signal and the second signal and to provide an output signal configured to cause steering of rear wheels (103) at the proposed rear wheel steering angle.

Abstract: Prodrugs of colchicine, de-acetyl colchicine, colcemid, and nocodazole are provided as therapies for the treatment of diseases ameliorated by the inhibition of microtubule polymerization.

Abstract: Example embodiments involve a metrics collection system for collecting software usage metrics from one or more client devices at deployments. A computer, such as a server configured to execute the metrics collection system, collects software usage metrics (e.g., as a metrics submission from a client device) of the software product at the deployment, identifies a metrics type of the software usage metrics collected, assigns the software usage metrics to a metrics category, and calculates and updates a metrics score of the metrics category, based on the software usage metrics collected.

Abstract: In mass spectrometry significant error is introduced during sample preparation (sample-to-sample error), during ion generation (ion suppression), and during ion transmission (ion transmission losses). We demonstrate the ability to correct for ion suppression and ion transmission losses, and that once corrected for ion losses, a sample-to-sample normalization of the analytical sample to the internal standard is possible. By normalizing to a standard sample the analytical sample becomes completely comparable to any similarly treated sample.

Abstract: Example embodiments involve a metrics collection system for collecting software usage metrics from one or more client devices at deployments. A computer, such as a server configured to execute the metrics collection system, collects software usage metrics (e.g., as a metrics submission from a client device) of the software product at the deployment, identifies a metrics type of the software usage metrics collected, assigns the software usage metrics to a metrics category, and calculates and updates a metrics score of the metrics category, based on the software usage metrics collected.

Abstract: A single plate capacitive bubble detection sensor. The detector may employ a single active plate. A parasitic capacitance of the active plate relative to the environment may be monitored without reference to any particular ground source. In this regard, highly sensitive measurements may be made of a tube disposed adjacent to the active plate to detect, for example, the presence of air, liquid, or a change between liquid and air in the tube.

Abstract: In mass spectrometry significant error is introduced during sample preparation (sample-to-sample error), during ion generation (ion suppression), and during ion transmission (ion transmission losses). We demonstrate the ability to correct for ion suppression and ion transmission losses, and that once corrected for ion losses, a sample-to-sample normalization of the analytical sample to the internal standard is possible. By normalizing to a standard sample the analytical sample becomes completely comparable to any similarly treated sample.

Abstract: A combination pillow and clothing article is configurable between a first configuration and a second configuration. The combination pillow and clothing article includes a first pillow portion, a second pillow portion, and a jumpsuit. The first pillow portion includes a cavity. The second pillow portion is detachably coupled to the first pillow portion. The jumpsuit is coupled to each of the first pillow portion and the second pillow portion. In the first configuration, the first pillow portion and the second pillow portion are coupled together. The jumpsuit is positioned at least partially within the cavity of the first pillow portion. In the second configuration, the first pillow portion and the second pillow portion are detached from each other and spaced apart. At least a portion of the jumpsuit extends between the first pillow portion and the second pillow portion.

Abstract: Provided herein are imidazolium polymers having steric hindrance at the 4-position of the imidazole moieties in the polymeric chain. The sterically-protected, N-methylated imidazolium polymers exhibit hydroxide stability in concentrated caustic solutions at elevated temperatures, such as at 100° C. and higher.