Abstract: The present invention discloses methods of modulating the activity of Group I mGluRs using a defined class of benzamide compounds. In one embodiment, methods of modulating the activity of mGluR1 are provided. In another embodiment, methods of modulating the activity of mGluR5 are provided. In still another embodiment, methods of simultaneously modulating the activities of both mGluR1 and mGluR5 are provided. The present invention also provides methods of treating diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of benzamide compounds. The present invention further provides methods of preventing diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of compounds.

Abstract: The present invention is directed to the method of use of effective pharmaceutical formulations for the treatment of diseases caused by apicomplexan parasites, said formulation comprised of a salicylanilide or salicylanilide derivative, disclosed herein, alone or in combination with one or more other active or excipient pharmaceutical substances. The present invention is further directed to the method of use of effective pharmaceutical formulations for the treatment of diseases caused by apicomplexan parasites, said formulation comprised of a combination of salicylanilides or salicylanilide derivatives, disclosed herein. The present invention is further directed to the method of use of effective pharmaceutical formulations for the treatment of diseases caused by apicomplexan parasites, said formulation comprised of a combination of salicylanilides or salicylanilide derivatives, disclosed herein, further comprised of one or more active or excipient pharmaceutical substances.

Abstract: The present invention discloses methods of modulating the activity of Group I mGluRs using a defined class of benzamide compounds. In one embodiment, methods of modulating the activity of mGluR1 are provided. In another embodiment, methods of modulating the activity of mGluR5 are provided. In still another embodiment, methods of simultaneously modulating the activities of both mGluR1 and mGluR5 are provided. The present invention also provides methods of treating diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of benzamide compounds. The present invention further provides methods of preventing diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of compounds.

Abstract: A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a combination thereof: wherein R1, R3, R4, and R5 are independently selected from H, OH, and ORa; R2 is selected from H, OH, and (C?O) (C1-7)alkyl; Ra is (C1-7)alkyl or (C?O)(C1-7)alkyl; or a derivative of the compound selected from N-oxide derivatives, prodrug derivatives, protected derivatives, isomers, and mixtures of isomers of the compound; or a pharmaceutically acceptable salt or solvate of the compound or the derivative. Compounds of formula I and II and pharmaceuticals compositions thereof are also presented.

Abstract: A night sight includes a notched bottom portion, permitting the use of a large objective lens for maximized light gathering capability while also permitting the night sight to be mounted with its center line relatively close to the center line of the barrel of the weapon with which it is used. This configuration permits the night sight to be mounted so that its center line is the same as the center line of a daytime telescopic sight used in conjunction with the night sight. The night sight includes a focusing assembly having decreased sensitivity to tilt or decenter, and a collimator mounted within a spherical bearing so that the collimator may be precisely aligned during assembly of the night sight. The night sight thereby ensures that an image viewed through the night sight appears to originate from the same angle as that with which the image entered the objective lens, and further resists a need to compensate for parallax during aiming.

Abstract: A night sight includes a notched bottom portion, permitting the use of a large objective lens for maximized light gathering capability while also permitting the night sight to be mounted with its center line relatively close to the center line of the barrel of the weapon with which it is used. This configuration permits the night sight to be mounted so that its center line is the same as the center line of a daytime telescopic sight used in conjunction with the night sight. The night sight includes a focusing assembly having decreased sensitivity to tilt or decenter, and a collimator mounted within a spherical bearing so that the collimator may be precisely aligned during assembly of the night sight. The night sight thereby ensures that an image viewed through the night sight appears to originate from the same angle as that with which the image entered the objective lens, and further resists a need to compensate for parallax during aiming.

Abstract: A night sight includes a notched bottom portion, permitting the use of a large objective lens for maximized light gathering capability while also permitting the night sight to be mounted with its center line relatively close to the center line of the barrel of the weapon with which it is used. This configuration permits the night sight to be mounted so that its center line is the same as the center line of a daytime telescopic sight used in conjunction with the night sight. The night sight includes a focusing assembly having decreased sensitivity to tilt or decenter, and a collimator mounted within a spherical bearing so that the collimator may be precisely aligned during assembly of the night sight. The night sight thereby ensures that an image viewed through the night sight appears to originate from the same angle as that with which the image entered the objective lens, and further resists a need to compensate for parallax during aiming.

Abstract: The invention provides compounds of formula I: wherein R1 to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.

Abstract: A system for reducing carbonaceous material is disclosed. The system includes a compartment configured to receive the carbonaceous material. An auger is located within the compartment and centered about a drive shaft. A rotational drive mechanism is coupled to the drive shaft and configured to rotate the auger to enable the carbonaceous material to travel through the compartment as the auger is rotated. A plurality of lifting arms are coupled to a surface of the auger. The lifting arms are configured to lift and stir the carbonaceous material as the auger is rotated. At least one microwave generator is coupled to the compartment and configured to radiate the carbonaceous material as it travels through the compartment to reduce the carbonaceous material into at least one chemical component of the carbonaceous material.

Abstract: Novel compounds which selectively bind to the ?-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the ?-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known ?-opioid receptor selectors as analgesics.

Abstract: Clustering is routinely applied in the exploratory analysis of microarray data. Missing entries arise from blemishes on the microarrays. The present invention provides a new method, and computer program and/or computer product thereof to impute missing values. The method involves the steps of clustering microarray data by partitioning the data into a select number of clusters, wherein each data point is iteratively moved from one cluster to another, until two consecutive iterations have resulted in the same partition pattern; obtaining a select number of estimates of the data in the clusters by probabilistic interference; and averaging the select number of estimates to obtain missing values in the microarray data. The method is superior to other imputation models as measured by root mean squared errors.

Abstract: Disclosed is a novel pharmacophore and novel inotropic compositions created from the novel pharmacophore. Also disclosed are methods of making and using the novel pharmacophore and method of use of novel compositions to treat heart diseases by inhibiting Na, K-ATPase.

Abstract: The invention provides compounds of formula I: wherein R1 to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.

Abstract: A night sight includes a notched bottom portion, permitting the use of a large objective lens for maximized light gathering capability while also permitting the night sight to be mounted with its center line relatively close to the center line of the barrel of the weapon with which it is used. This configuration permits the night sight to be mounted so that its center line is the same as the center line of a daytime telescopic sight used in conjunction with the night sight. The night sight includes a focusing assembly having decreased sensitivity to tilt or decenter, and a collimator mounted within a spherical bearing so that the collimator may be precisely aligned during assembly of the night sight. The night sight thereby ensures that an image viewed through the night sight appears to originate from the same angle as that with which the image entered the objective lens, and further resists a need to compensate for parallax during aiming.

Abstract: An active vibration control (AVC) system includes a shaft-driven gearbox mounted force generator (GMFG) mounted to a main rotor transmission. The GMFGs receive shaft power from an output shaft driven by the main rotor transmission and/or engine-to-transmission gearbox to avoid separate drive motors.

Abstract: A method and device for reducing vibratory noise in a system with an integral rotating member includes independently operable drive means for controlling the angular velocity of at least two masses. Control signals manipulate the drive means to allow each mass to rotate at optimal speed, direction and phase for reducing the noise induced in the system by the rotating member.

Abstract: The present invention generally relates to the field of plant genetics and protein biochemistry. More specifically, the present invention relates to modified proteins having an increased number of essential amino acids. The present invention provides proteins modified to have an increased number of essential amino acids, nucleic acid sequences encoding the enhanced proteins, and methods of designing, producing, and using the same. The present invention also includes compositions, transformed host cells, transgenic plants, and seeds containing the enhanced proteins, and methods for preparing and using the same.

Abstract: An active mount is provided for use in a rotary wing aircraft between each of the gearbox and airframe mounting locations for mechanically suspending the airframe from the gearbox. The active mount comprises first and second linear hydraulic actuators each having a principal axis. The length of the actuators is variable along the principal axis for providing relative movement between the airframe and the gearbox. The principal axes of the actuators are adapted to lie in the directional planes of the primary forces necessary for supporting the airframe and acting on the transmission gearbox mounting locations for providing movement of the gearbox relative to the airframe in the planes at a frequency for reducing the transfer of vibration through the active mount to the airframe. A system for reducing vibration in the rotary wing aircraft further comprises a hydraulic system for supplying a controlled flow of pressurized hydraulic fluid to the actuators.

Abstract: An active mount is provided for use in a rotary wing aircraft between each of the gearbox and airframe mounting locations for mechanically suspending the airframe from the gearbox. The active mount comprises first and second linear hydraulic actuators each having a principal axis. The length of the actuators is variable along the principal axis for providing relative movement between the airframe and the gearbox. The principal axes of the actuators are adapted to lie in the directional planes of the primary forces necessary for supporting the airframe and acting on the transmission gearbox mounting locations for providing movement of the gearbox relative to the airframe in the planes at a frequency for reducing the transfer of vibration through the active mount to the airframe. A system for reducing vibration in the rotary wing aircraft further comprises a hydraulic system for supplying a controlled flow of pressurized hydraulic fluid to the actuators.