Abstract: An anti-IL-22 antibody or antibody fragment that binds to both human IL-22 and a mammalian IL-22 as well as modified anti-IL-22 antibodies and antibody fragments. Pharmaceutical compositions and kits comprising the antibody or antibody fragment are also provided. Also provided are methods for treatment of various IL-22 mediated conditions and diseases.

Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.

Abstract: Stability testing for memory overclocking is described. In accordance with the described techniques, operation of a memory with overclocked memory settings is testing during a boot up process of a computing device. Test results based on the testing are exposed via a user interface. The test results predict a stability of the memory over a subsequent time period if the memory is configured to operate with the overclocked memory settings.

Abstract: A non-transitory computer-readable storage medium can include instructions stored thereon that, when executed by at least one processor, are configured to cause a computing device to determine, in response to a change in a refresh rate of a display, an encoded intensity of at least a portion of an image presented by the display, determine that the encoded intensity is within a predetermined range, and based on determining that the encoded intensity is within the predetermined range, adjust an intensity of a signal for the portion of the image.

Abstract: Ultrasound imaging is a non-invasive, non-radioactive, and low cost technology for diagnosis and identification of implantable medical devices in real time. Developing new ultrasound activated coatings is important to broaden the utility of in vivo marking by ultrasound imaging. Ultrasound responsive macro-phase segregated micro-composite thin films were developed to be coated on medical devices composed of multiple materials and with multiple shapes and varying surface area. The macro-phase segregated films having silica micro-shells in polycyanoacrylate produces strong color Doppler signals with the use of a standard clinical ultrasound transducer. Electron microscopy showed a macro-phase separation during slow curing of the cyanoacrylate adhesive, as air-filled silica micro-shells were driven to the surface of the film. The air sealed in the hollow space of the silica shells acted as an ultrasound contrast agent and echo decorrelation of air exposed to ultrasound waves produces color Doppler signals.

Abstract: The present disclosure provides a bioprinting system (100) for printing a liquid directly onto a subject. The bioprinting system (100) comprises a bioprinting assembly (102). Optionally, a robotic arm (104) and a control system (150) are provided. The bioprinting assembly (102) may be coupled to the robotic arm (104) to be positionable relative to the subject. The bioprinting assembly (102) is configured to dispense the liquid onto the subject and comprises a reservoir (120) for holding the liquid and a loading mechanism (134) to prime the reservoir (120) with the liquid directly prior to printing. The loading mechanism (134) has a one way inlet to permit liquid to be loaded into the reservoir (120) and prevent fluid from exiting the reservoir via the one way inlet. There is also provided associated methods.

Abstract: A walker for an animal can include a body support assembly configured to provide support for a torso of the animal. A rear portion of the body support assembly can be configured to allow motion of rear legs of the animal on a surface. The walker can further include a front support assembly coupled to a front portion of the body support assembly, and configured to allow front legs of the animal to rest thereon such that the front legs are held away from the surface. The walker can further include a leg assembly coupled to the body support assembly, and configured to provide support for the animal in place of the front legs, and to facilitate motion of the animal on the surface based on the motion of the rear legs.

Abstract: A method and system for providing a user who places a telephone call on hold with a partial hold option. When a user places a first call on partial hold and picks up a second call, the user can still hear conversation and activity that occurs on the first call. For example a user participating in a conference call may receive a second call. The user can place the conference call on partial hold and pick up a second call (i.e. engage in a conversation on a second telephone call). However, the incoming channel to the conference call will remain active and the user will be able to hear, in the background, what is taking place in the conference call. Should the user hear something interesting in the conference call, or if the user hears someone ask a question directed to the particular use, the user can switch back to the conference call.

Abstract: A method for performing a fibre channel arbitrated loop integrity test using a fibre channel switch element is provided. The method includes, sending a fibre channel frame through the arbitrated loop; receiving the fibre channel frame after it has traversed through the arbitrated loop; performing a data compare between the fibre channel frame that was sent and the fibre channel frame that is received; detecting internal errors, if any, in the traversed fibre channel loop; and isolating a module that may have generated the error. The switch element includes, a cascade port that is used to couple one fibre channel switch element to another in a loop; and a port that sends a fibre channel frame through the loop and detects internal errors based on the comparison and a isolates a module that may have generated the internal error.

Abstract: A method and a fibre channel switch element for processing receive-modify-send (“RMS”) frames in a fibre channel network are provided. The method includes, determining if a received frame is a RMS frame; modifying the RMS frame without copying the RMS frame to a transmit buffer; and transmitting the modified frame. The RMS frame is modified in a receive buffer before being sent to the transmit buffer and a port state machine controls the receive buffer where RMS frames are modified. The switch element includes a port having a state machine that determines if a received frame needs to be modified before being transmitted, and if the frame is to be modified then such modification occurs in a receive buffer without being copied to a transmit buffer before such modification. A buffer select logic selects the appropriate buffer for modifying and transmitting frames from.

Abstract: A method and fibre channel switch element is provided for isolating a defective device that is coupled to a fibre channel arbitrated loop. The method includes, isolating a port if a loop initialization primitive (“LIP”) is detected from a device coupled to the arbitrated loop; configuring the device and acquiring an AL_PA; determining if the device is sending LIPs; and isolating the device if the device continues to send LIPs. The switch element includes, a port having an isolation state machine that allows the switch element to isolate a device whose behavior may result in disruption of other devices in the network. The state machine may also configure a device after detecting disruptive parameters from the device and perform diagnostic operations on the device.

Abstract: A method and fibre channel switch element for capturing data in a fibre channel system is provided. The method includes, detecting a condition for enabling data capture; setting a control bit to enable data capture; and capturing data based on the set control bit. The switch element includes, a diagnostic port that can configured as a traditional communication port and/or a data capture port depending on incoming frame data. The diagnostic port filters incoming frames, which is used to enable data capture.

Abstract: A method and a switch element for buffer utilization in a network are provided. The method includes, receiving plural frames in a first buffer, if the received frames are less than a full size frame and can be accommodated in the first buffer; sending an available buffer signal after the first buffer has been utilized; and receiving a frame after the available buffer signal has been sent. The switch element includes, a port having a state machine that monitors buffer utilization by receiving plural frames in a first buffer. Also, a method for managing a receive queue for a network is provided. The method includes, copying a receive descriptor queue entry from a first location to another location while a processor is performing a critical operation; and freeing the receive queue entry such that the processor can complete the critical operation.

Abstract: A method and system for detecting orphaned CLS primitives in a fibre channel network having a fibre channel switch element coupled to an arbitrated loop is provided. The method includes, sending an OPN primitive to a switch element port's own AL_PA to open a connection with itself; and determining if a CLS primitive is received within a loop a latency period. If a CLS primitive is received within the latency period then the CLS primitive is classified as an orphan and the orphaned CLS primitive is removed by the switch element by enabling a firmware based removal feature. The switch element includes a port that arbitrates for the arbitrated loop ownership and sends an OPN primitive to its own AL_PA.