Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to GITR and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.

Abstract: Disclosed herein are compositions and methods for treating cancer in a subject. This involves administering an oncolytic virus containing a heterologous DNA sequence encoding one or more immunomodulatory and/or immunostimulatory polypeptide(s) of interest to the subject under conditions effective to enhance an anti-tumor immune response in the subject, and to treat cancer. It also relates to a method of enhancing the delivery to and distribution within a tumor mass of therapeutic viruses.

Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to NRP-1 and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.

Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to TIGIT and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.

Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to TIGIT and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.

Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to TIGIT and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.

Abstract: Exemplary embodiments of methods and apparatuses to split incoming data into a plurality of sub-channels to allow parallel processing are described. A packet is received over a network. The packet is compared against a filter. The packet is routed to a process sub-channel in a memory based on the comparing. The process sub-channel is one of the plurality of process sub-channels that are configured to allow parallel processing. In one embodiment, the filter includes user defined criteria for the packet.

Abstract: A time marker for a data packet stream is generated. The packets are grouped into a block based on the time marker. The block of data packets is stored in a memory. A block of the data packets can be terminated based on the time marker. A block header is generated for the block. Statistics associated with the packet stream is captured based on the time marker.

Abstract: A method is disclosed. The method includes capturing a first packet at a network monitoring card, capturing the first packet at a first filter, generating a first tag corresponding to the first filter and storing the first packet in memory with the first tag.

Abstract: Media Access Control (MAC) layer transmit and receive buffering with multi-level prioritization. The receive buffering allocates receive buffers for receiving frame data from a PHY interface in priority order using both a static and dynamic buffer allocation, and delivers completed buffers queued in a multi-level priority queue to a host interface highest priority first. The transmit buffering delivers completed buffers queued in a multi-level priority queue to the PHY interface in priority order. When the multi-level priority queue contains a buffer that is higher priority than one being prepared for transmit, a priority-based interruption causes the transmit processing of the buffer to be suspended at its current state with the higher priority buffer taking its place. Upon completion of the higher priority buffer, the suspended buffer is resumed at its current state.

Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

Abstract: Nucleic acid and protein sequences relating to a gene required for systemic RNAi are disclosed. The SID-1 and 2 proteins are shown to be required for systemic RNAi. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the <i>sid-1</i><i>and</i>2 genes and proteins are disclosed. Also provided are methods for reducing the expression of a target gene in a cell, a population of cells, or an animal.

Abstract: Media Access Control (MAC) layer transmit and receive buffering with multi-level prioritization. The receive buffering allocates receive buffers for receiving frame data from a PHY interface in priority order using both a static and dynamic buffer allocation, and delivers completed buffers queued in a multi-level priority queue to a host interface highest priority first. The transmit buffering delivers completed buffers queued in a multi-level priority queue to the PHY interface in priority order. When the multi-level priority queue contains a buffer that is higher priority than one being prepared for transmit, a priority-based interruption causes the transmit processing of the buffer to be suspended at its current state with the higher priority buffer taking its place. Upon completion of the higher priority buffer, the suspended buffer is resumed at its current state.