Patents by Inventor William Wold

William Wold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oncolytic Adenovirus Armed with Therapeutic Genes
    Publication number: 20080292592
    Abstract: The present invention involves compositions and methods for treating preventing cancer using compositions including replication competent adenovirus. The application competent adenovirus may or may not encode a therapeutic polynucleotide.
    Type: Application
    Filed: May 2, 2005
    Publication date: November 27, 2008
    Inventors: Sunil Chada, William Wold, Lou Zumstein
  • Replication-competent anti-cancer vectors
    Publication number: 20060029596
    Abstract: Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.
    Type: Application
    Filed: October 13, 2005
    Publication date: February 9, 2006
    Inventors: William Wold, Karoly Toth, Konstantin Doronin, Ann Tollefson
  • Models for viral-based cancer therapy
    Publication number: 20050201936
    Abstract: The present invention relates to the use of cotton rats and Syrian hamsters as models for adenoviral gene therapy. In particular, the models are directed to the examination of the ability of various replicative, non-replicative and conditionally-replicative adenovirus vectors to treat cancer.
    Type: Application
    Filed: February 14, 2005
    Publication date: September 15, 2005
    Inventors: William Wold, Karoly Toth, Maria Thomas
  • Adenovirus replication-competent vectors expressing trail
    Publication number: 20040213764
    Abstract: The present invention provides replication-competent Adenoviral vectors that express TRAIL and ADP. In a particular aspect, TRAIL and/or ADP are highly expressed using the Adenovirus major late promoter or other promoter. Methods of treating hyperproliferative disorders using such vectors, alone or in combination with secondary therapies, also are described.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 28, 2004
    Inventors: William Wold, Ann Tollefson, Baoling Ying