Patents by Inventor William Ying Khee Hwang

William Ying Khee Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOSUPPRESSIVE COMPOSITION FOR USE IN TREATING IMMUNOLOGICAL DISORDERS
    Publication number: 20230181734
    Abstract: The present disclosure describes a pharmaceutical composition comprising at least one antibody and at least one mesenchymal stromal cell-derived protein. Disclosed herein is also the use of said pharmaceutical composition for treating immunological diseases, for example alloimmune and autoimmune diseases. Further disclosed herein is the use of the pharmaceutical composition for immunomodulation.
    Type: Application
    Filed: November 3, 2022
    Publication date: June 15, 2023
    Inventors: Xiubo Fan, William Ying Khee Hwang, Hsiu Ling Low, Julian Thumboo, Chin Teck Ng
  • Immunosuppressive composition for use in treating immunological disorders
    Patent number: 11491221
    Abstract: A pharmaceutical composition comprising at least one antibody and at least one mesenchymal stromal cell-derived protein, use of the pharmaceutical composition for treating immunological diseases, for example alloimmune and autoimmune diseases, and use of the pharmaceutical composition for immunomodulation.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: November 8, 2022
    Assignees: Singapore Health Services Pte Ltd, Singapore General Hospital
    Inventors: Xiubo Fan, William Ying Khee Hwang, Hsiu Ling Low, Julian Thumboo, Chin Teck Ng
  • Methods of treating immunological disorders using immunosuppressive compositions
    Patent number: 11246910
    Abstract: The present disclosure describes a method of treating immunological disorders, for example alloimmune and autoimmune diseases, using a pharmaceutical composition comprising at least one mesenchymal stromal cell-derived protein Further disclosed herein is the use of the pharmaceutical composition for immunomodulation.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: February 15, 2022
    Assignee: Singapore Health Services Pte Ltd
    Inventors: Xiubo Fan, William Ying Khee Hwang, Hsiu Ling Low, Julian Thumboo, Chin Teck Ng
  • IMMUNOSUPPRESSIVE COMPOSITION FOR USE IN TREATING IMMUNOLOGICAL DISORDERS
    Publication number: 20210252140
    Abstract: The present disclosure describes a pharmaceutical composition comprising at least one antibody and at least one mesenchymal stromal cell-derived protein. Disclosed herein is also the use of said pharmaceutical composition for treating immunological diseases, for example alloimmune and autoimmune diseases. Further disclosed herein is the use of the pharmaceutical composition for immunomodulation.
    Type: Application
    Filed: August 18, 2017
    Publication date: August 19, 2021
    Inventors: Xiubo Fan, William Ying Khee Hwang, Hsiu Ling Low, Julian Thumboo, Chin Teck Ng
  • SUBSTITUTED AZOLE DERIVATIVES FOR GENERATION, PROLIFERATION AND DIFFERENTIATION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS
    Publication number: 20190359941
    Abstract: The present invention relates to substituted azole derivatives in combination with cytokines in the ex vivo expansion of CD34+ hematopoietic stem and progenitor cells (HSPC) in a biological sample, more particularly the expansion of these cells obtained from non-enriched, i.e., the mononuclear fraction of the biological sample. The present invention further describes the transplantation regimen of the expanded hematopoietic graft developed through xenotransplantation studies. In a preferred embodiment, the combination comprising the azole based compounds and cytokines selected from SCF, TPO, FLT-3L and IGFBP-2 and results in the expansion of expansion of CD45+CD34+CD38?CD45RA?CD90+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA?CD90+CD49f+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA? hematopoietic progenitor cells from the mononucleated cells isolated from umbilical cord blood.
    Type: Application
    Filed: August 18, 2017
    Publication date: November 28, 2019
    Applicants: National University of Singapore, Singapore Health Services Pte Ltd
    Inventors: Sudipto BARI, Christina Li Lin CHAI, Gigi Ngar Chee CHIU, William Ying Khee HWANG, Joo Leng LOW, Qixing ZHONG
  • IMMUNOSUPPRESSIVE COMPOSITION FOR USE IN TREATING IMMUNOLOGICAL DISORDERS
    Publication number: 20190262424
    Abstract: The present disclosure describes a pharmaceutical composition comprising at least one antibody and at least one mesenchymal stromal cell-derived protein. Disclosed herein is also the use of said pharmaceutical composition for treating immunological diseases, for example alloimmune and autoimmune diseases. Further disclosed herein is the use of the pharmaceutical composition for immunomodulation.
    Type: Application
    Filed: February 22, 2019
    Publication date: August 29, 2019
    Inventors: Xiubo Fan, William Ying Khee Hwang, Hsiu Ling Low, Julian Thumboo, Chin Teck Ng