Abstract: The present invention relates to an auto-injector. The auto-injector includes a housing for receiving a syringe having a plunger, a needle, and a barrel containing a dose of medicament; a drive mechanism configured to, when triggered by a user, automatically drive the plunger from a first position to a second position to expel the dose from the barrel of the syringe through the needle at a front end of the auto-injector; a detector arrangement configured to detect a state of the plunger including at least departure from the first position and arrival at the second position; and an indicator arrangement comprising a display having one or more electrically-operated display elements and configured to provide, responsive to the detector arrangement detecting the departure of the plunger from the first position, a visual indication comprising cycles of indications, the cycles of indications repeating until the detector arrangement detects the arrival of the plunger at the second position.

Abstract: A manifold for connection to a waste collection vacuum device. The manifold includes suction port tubes and a vacuum port that define interconnected fluid communication pathways such that no walls define proximal and distal ends of the manifold. Tabs are coupled to at least one of the interconnected fluid communication pathways. The tabs interface with keyed surfaces of the waste collection vacuum device so as to facilitate positive location and mechanical fixation with the waste collection vacuum device. A web of material may extend between the suction port tubes to increase torsional strength of the manifold. There may be two webs of material with each coupled to opposing pairs of four suction port tubes. The vacuum port may be a single vacuum port.

Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy (“IVL”) system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing and/or assessing the electrical energy needed to generate an electrical arc between a set of spaced-apart electrodes disposed within a fluid-fillable member.

Abstract: A method for optimizing a knee arthroplasty surgical procedure includes receiving pre-operative data comprising (i) anatomical measurements of the patient, (ii) soft tissue measurements of the patient's anatomy, and (iii) implant parameters identifying an implant to be used in the knee arthroplasty surgical procedure. An equation set is selected from a plurality of pre-generated equation sets based on the pre-operative data. During the knee arthroplasty surgical procedure, patient-specific kinetic and kinematic response values are generated and displayed using an optimization process. The optimization process includes collecting intraoperative data from one or more surgical tools of a computer-assisted surgical system, and using the intraoperative data and the pre-operative data to solve the equation set, thereby yielding the patient-specific kinetic and kinematic response values. A visualization is then provided of the patient-specific kinetic and kinematic response values on the displays.

Abstract: The present invention is directed to compositions containing a fatty acid amide hydrolase inhibitor and methods of use thereof for treatment of trauma-related psychiatric disorders in a patient in need thereof, particularly those that exhibiting hyperarousal symptomatology.

Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.

Abstract: Systems, devices, and methods including: a latching mechanism comprising: a first latch configured to attach to a door of an unmanned aerial vehicle (UAV); a second latch configured to attach to a portion of the UAV distal from the first latch; a string connected between the first and second latch, where the string secures the door shut; at least two radio modules in communication with a ground control station; and at least two burn wires in contact with a portion of the string between the first latch and the second latch; where current from a backup battery passes to at least one burn wire when the burn signal is received, where the burn wire causes the connection between the first latch and the second latch to be broken and the door of the UAV is separated from the UAV.

Abstract: A razor wire barrier or container is disclosed. In some embodiments, the razor wire container includes a plurality of walls defining an interior area for securing object(s) therein. The razor wire container may further include panels or razor wire along a frame defined by the plurality of walls, and a component receptacle extending along the frame. The razor wire container may include a movable access component to provide access to the object(s). The component receptacle is operable to receive a component of a machine for moving the frame. In some embodiments, the component receptacle is a hollow member operable to receive a forklift prong. In some embodiments, the section of razor wire includes one or more panels of razor wire.

Abstract: The present disclosure is directed to systems and methods enabling federated learning of atmospheric models for satellite-based navigation, via crowdsourcing training data. One method includes, causing, at a computing device, a determination of an error metric based on a difference between a set of measured values and a set of expected values. The set of expected values is based on an atmospheric model and a geolocation. The set of measured values is based on a set of satellite signals received at the computing device from a set of satellites. The error metric may be for the atmospheric model. The method further includes causing a transmission of a data structure from the computing device to an atmospheric model service. The transmitted data structure encodes the error metric (e.g., training data). The atmospheric modeling service employs Bayesian inference and the error metric as a conditional probability to refine the atmospheric model.

Abstract: The present disclosure relates to mounting apparatus, and related methods and components, for mounting an accessory to a mounting structure. In one or more embodiments, the mounting structure is a crossbar and/or a rail of a vehicle. In one or more embodiments, a mounting apparatus includes an actuator and a handle pivotably coupled to the actuator. The mounting apparatus also includes one or more locking pins. The handle is configured to rotate relative to a rotational axis and pivot relative to a pivot axis, and one or more links are disposed such that rotation of the handle moves the one or more links to rotate the one or more locking pins.

Abstract: A gas turbine engine has a turbomachine comprising compressor, combustion, and turbine sections. The gas turbine engine defines a maximum exhaust gas temperature, a maximum drive turbine shaft torque, and a corrected specific power. The gas turbine engine includes a nozzle vane and an engine casing defining a fluid supply plenum. The engine casing is configured to route cooling fluid from the fluid supply plenum to the nozzle vane. The routing of the cooling fluid facilitates cooling of the nozzle vane and increases an overall pressure ratio of the gas turbine engine. Integration of the cooling fluid routing within the engine casing reduces parasitic bleed air losses, enables tighter turbine stage spacing, and improves the thermal efficiency of the engine, thereby enhancing performance at elevated pressure ratios.

Abstract: An aircraft extending between a forward end and an aft end is provided. The aircraft includes an auxiliary power unit positioned proximate the aft end of the aircraft, the auxiliary power unit having an auxiliary power unit inlet duct and an auxiliary power unit exhaust duct, and a boundary layer ingestion fan positioned proximate the aft end of the aircraft, the boundary layer ingestion fan having a support shaft, wherein the auxiliary power unit exhaust duct extends through a portion of the support shaft of the boundary layer ingestion fan.

Abstract: A power generation system may include an impoundment structure at least partially defined by a plurality of precast segments. At least one of the precast segments may include a precast form and at least one precast infill block. The power generation system may include a powerhouse. At the powerhouse, a fluid conduit is coupled to an intake tube and a draft tube in respective transition regions to enable fluid to flow into a power generating module to produce electrical power, and transition collar(s) may be employed to secure connectivity between the fluid conduit and the intake tube and the draft tube. The power generating module may be arranged such that an intake port is elevated with respect to a draft port at the power generating module. Sensors may be employed to monitor integrity of elements of the power generation system.

Abstract: A soybean cultivar designated 22150935 is disclosed. The invention relates to the seeds of soybean cultivar 22150935, to the plants of soybean cultivar 22150935, to the plant parts of soybean cultivar 22150935, and to methods for producing progeny of soybean cultivar 22150935. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 22150935. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 22150935, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 22150935 with another soybean cultivar.

Abstract: A soybean cultivar designated 24340118 is disclosed. The invention relates to the seeds of soybean cultivar 24340118, to the plants of soybean cultivar 24340118, to the plant parts of soybean cultivar 24340118, and to methods for producing progeny of soybean cultivar 24340118. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 24340118. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 24340118, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 24340118 with another soybean cultivar.

Abstract: A system may display a set of images to a user, the set of images includes a plurality of synthetic images output by a generative adversarial network (GAN) includes a generator and a discriminator, and a plurality of non-synthetic images, detect a user response to the set of images, the user response includes at least a gaze of the user relative to the set of images, and train the GAN based at least on the user response, including tuning the generator based on the gaze of the user.

Abstract: A surgical system comprising a processing device configured to implement a trained machine learning model, the processing device being configured to: receive first data having a first data format from a sensing device; receive additional data indicating a condition of the surgical system; in dependence on the additional data, input the first data or data derived therefrom to the trained machine learning model; and output second data having a second data format.

Abstract: A method of assembling a protective sheath to a surgical instrument comprises advancing the protective sheath over a distal working end of a surgical instrument shaft to a relatively proximally disposed sheath connector portion of the surgical instrument; moving a retention mechanism of the sheath into alignment with the sheath connector portion; and moving a moveable locking feature from a first configuration permitting the retention mechanism to be moved relative to the sheath connector portion to a second configuration in which complementary engagement features on the retention mechanism and the sheath connector portion are lockably engaged to retain the sheath in position on the instrument.

Abstract: A soybean cultivar designated 24450465 is disclosed. The invention relates to the seeds of soybean cultivar 24450465, to the plants of soybean cultivar 24450465, to the plant parts of soybean cultivar 24450465, and to methods for producing progeny of soybean cultivar 24450465. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 24450465. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 24450465, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 24450465 with another soybean cultivar.

Abstract: A soybean cultivar designated 23450022 is disclosed. The invention relates to the seeds of soybean cultivar 23450022, to the plants of soybean cultivar 23450022, to the plant parts of soybean cultivar 23450022, and to methods for producing progeny of soybean cultivar 23450022. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 23450022. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 23450022, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 23450022 with another soybean cultivar.