Abstract: The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: The invention relates to imidazopyridines of Formula (I) and pharmaceutically acceptable salts thereof, wherein R0 to R5 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: Embodiments described herein provide techniques to enable the dynamic reconfiguration of memory on a general-purpose graphics processing unit. One embodiment described herein enables dynamic reconfiguration of cache memory bank assignments based on hardware statistics. One embodiment enables for virtual memory address translation using mixed four kilobyte and sixty-four kilobyte pages within the same page table hierarchy and under the same page directory. One embodiment provides for a graphics processor and associated heterogenous processing system having near and far regions of the same level of a cache hierarchy.

Abstract: Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess-suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.

Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: The present invention relates to the use of cannabinoids in the treatment of a neurodegenerative disease or disorder. In particular the cannabinoids cannabidiolic acid (CBDA) and cannabidivarin (CBDV) were able to produce neuroprotective effects in a mouse model of neurodegenerative disease. In particular these effects were associated with the symptoms associated with amyotrophic lateral sclerosis (ALS). Furthermore, the combination of the cannabinoid tetrahydrocannabinol (THC) with the drug olexisome provided a synergistic disease modifying effect in a mouse model of neurodegenerative disease. In particular these effects were associated with the symptoms associated with ALS.

Abstract: An apparatus for demonstrating the use of a medical device includes a body adapted for receiving the medical device. The body includes at least a portion adapted for viewing the medical device when positioned in the body. A cover is provided for selectively covering the portion of the body adapted for viewing the medical device. A kit and related methods are also disclosed.

Abstract: A metal air battery cell has a sealed pouch defined by a metallocene film and a gas and liquid impermeable flexible layer, and an electrochemical cell contained within the pouch. The metallocene film and gas and liquid impermeable flexible layer are sealed to each other and around the electrochemical cell.

Abstract: A metal air battery cell has a sealed pouch defined by a metallocene film and a gas and liquid impermeable flexible layer, and an electrochemical cell contained within the pouch. The metallocene film and gas and liquid impermeable flexible layer are sealed to each other and around the electrochemical cell.

Abstract: A metal air battery cell has a sealed pouch defined by a metallocene film and a gas and liquid impermeable flexible layer, and an electrochemical cell contained within the pouch. The metallocene film and gas and liquid impermeable flexible layer are sealed to each other and around the electrochemical cell.

Abstract: A metal air battery cell has a sealed pouch defined by a metallocene film and a gas and liquid impermeable flexible layer, and an electrochemical cell contained within the pouch. The metallocene film and gas and liquid impermeable flexible layer are sealed to each other and around the electrochemical cell.

Abstract: Computer implemented methods are provided for facilitating social engineering campaigns. The methods generally include maintaining at least one database that includes metadata for a plurality of fictional personas, metadata for a plurality of potential targets, information for a plurality of social engineering campaigns, such as a plurality of campaign scenarios, and information regarding social engineering successes with respect to at least one fictional persona, at least one potential target, at least one social engineering campaign, or a combination thereof. The method further includes receiving a selection of a campaign scenario from the plurality of campaign scenarios, receiving a selection of at least one of the plurality of potential targets, and selecting at least one of the plurality of fictional personas for use in a social engineering campaign based on an expected effectiveness of the given fictional personas with respect to the selected targets.

Abstract: A secondary battery recombination system includes catalyst and hydrophobic gas diffusion layers defining an electrode that recombines hydrogen and oxygen into water, and a scaffold encapsulating and in non-bonded contact with the electrode. The electrode may be carbon cloth, carbon felt, carbon foam, or carbon paper. The scaffold may be expanded metal or perforated foil.

Abstract: An acoustic technique designed to increase the gas-dissolution rate of a bubble in a liquid media is proposed. Increased gas-dissolution rate is achieved by increasing the bubble's surface-to-volume ratio via bubble fragmentation. This is achieved by attaching an electroacoustic transducer to the system or load in which bubbles travel and exciting the transducer at the frequency of resonance. The electric resonance of the transducer attached to the system corresponds in frequency to the mechanical resonance of the system or load which allows for achieving such state without the use of an internally placed hydrophone to certify the resonance state. The acoustic bubble fragmentation technique increased the dissolution rate 4 to 5 times of bubbles with initial diameters between 150 and 550 ?m in distilled water and in medical grade saline solution.

Abstract: A method can include receiving data characterizing a first property of an asset over a first time period. The method can also include receiving data characterizing user interaction with an interactive graphical object. The method can further include determining, by a predictive model, data characterizing the first property of the asset over a second time period. The determining can be based in part on the received data characterizing the user interaction. The method can also include rendering, in a graphical display space, one or more of a first plot of the received data characterizing the first property over the first time period and a second plot of the determined data characterizing the first property over the second time period.

Abstract: A method can include receiving data identifying an industrial asset. The method can also include receiving data characterizing one or more sensors configured to detect a first property of the asset. The method can further include determining a first graphical representation of the asset based on the received data identifying the industrial asset, and a second graphical representation of a first sensor of the one or more sensors based on the received data characterizing one or more properties of one or more sensors. The method can further include rendering, in a graphical display space, the first graphical representation and the second graphical representation. One or more visual properties of the second graphical representation can be indicative of one or more properties of the first sensor and/or the detected first property of the asset.

Abstract: An electrode assembly includes an electrode saturated with electrolyte, and one or more ionically conductive and electronically insulating cellulose acetate coatings forming a continuous and conformal film adhered to and encapsulating the electrode.

Abstract: A metal-air battery cell includes an electrode assembly and a sealed pouch. The electrode assembly includes an air electrode, a negative electrode, a separator in contact with and disposed between the electrodes, and a hydrophobic gas diffusion layer in contact with a side of the air electrode opposite the separator. The pouch envelops the electrode assembly and contains an electrolyte therein. The pouch is defined by a gas permeable hydrophobic flexible layer in contact with the hydrophobic gas diffusion layer. The electrode assembly further includes a terminal extending from and away at least one of the electrodes, and through the pouch. Opposing sides of the pouch are sealed to each other and around the terminal.

Abstract: A metal-air battery cell includes an electrode assembly and a sealed pouch. The electrode assembly includes an air electrode, a negative electrode, a separator in contact with and disposed between the electrodes, and a hydrophobic gas diffusion layer in contact with a side of the air electrode opposite the separator. The pouch envelops the electrode assembly and contains an electrolyte therein. The pouch is defined by a gas permeable hydrophobic flexible layer in contact with the hydrophobic gas diffusion layer. The electrode assembly further includes a terminal extending from and away at least one of the electrodes, and through the pouch. Opposing sides of the pouch are sealed to each other and around the terminal.

Abstract: A method can include receiving data characterizing a first property of an asset over a first time period. The method can also include receiving data characterizing user interaction with an interactive graphical object. The method can further include determining, by a predictive model, data characterizing the first property of the asset over a second time period. The determining can be based in part on the received data characterizing the user interaction. The method can also include rendering, in a graphical display space, one or more of a first plot of the received data characterizing the first property over the first time period and a second plot of the determined data characterizing the first property over the second time period.