Abstract: A lipid removal device for treating Meibomian gland dysfunction includes a housing defining a compartment. A thermally conductive coupler is mounted in a hollow seat formed on an end of the housing. A first end of the coupler has a coupling portion engaged with a needle to be inserted into a blocked Meibomian gland of an eyelid of a human body for melting and removing lipids blocking the Meibomian gland. A heating member is mounted in the compartment and connected to a second end of the coupler. A temperature sensor is mounted in the compartment and connected to the coupler. A control device is mounted in the compartment and electrically connected to the heating member and the temperature sensor. The control device cooperates with the temperature sensor to control a temperature of the needle to be in a preset temperature range by controlling on/off of an electric power source for the heating member.