Abstract: The present invention relates to chronic nightly use of lasmiditan for the prevention of migraine, particularly therapy resistant migraine which is defined herein as migraine refractory to two or more prior monotherapy and/or dual therapy treatment or prevention regimens.

Abstract: Pharmaceutical formulations for anti-CGRP antibodies, and methods of using the same, are provided which are useful as treatment for migraines, episodic headaches, chronic headaches, chronic cluster headaches, and episodic cluster headaches.

Abstract: The present invention relates to chronic nightly use of lasmiditan for the prevention of migraine, particularly therapy resistant migraine which is defined herein as migraine refractory to two or more prior monotherapy and/or dual therapy treatment or prevention regimens.

Abstract: A system for custom categorization of digital media content includes a server and a database for storing user accounts. The server provides a user interface to allow a user to review, purchase, and download to a user device one or more digital products. The server further establishes one or more wish lists of the user upon receipt of user instructions, where each of the wish lists is associated with the user account. The server further receives a user selection of one of the digital products. The user selection can also indicate a selected wish list of the user. In response to the user selection, the server links a selected digital product with the selected wish list. The user interface is further configured to allow the user to review all digital products linked to all of the wish lists of the user.

Abstract: The present invention relates to combinations of lasmiditan and a calcitonin gene-related peptide (CGRP) antagonist, for example the combination of lasmiditan and galcanezumab, and to methods of using the combinations for treatment of migraine, particularly migraine inadequately controlled by lasmiditan or a CGRP antagonist therapy alone, and more particularly, to treat therapy resistant migraine which is defined herein as migraine refractory to two or more prior monotherapy and/or dual therapy treatment regimens.

Abstract: A system for custom categorization of digital media content includes a server and a database for storing user accounts. The server provides a user interface to allow a user to review, purchase, and download to a user device one or more digital products. The server further establishes one or more wish lists of the user upon receipt of user instructions, where each of the wish lists is associated with the user account. The server further receives a user selection of one of the digital products. The user selection can also indicate a selected wish list of the user. In response to the user selection, the server links a selected digital product with the selected wish list. The user interface is further configured to allow the user to review all digital products linked to all of the wish lists of the user.

Abstract: An exemplary system for determining vehicle salvage value includes a valuation subsystem configured to communicate with one or more access devices over a data communication network. The valuation subsystem includes a bid module and a valuation module. The bid module is configured to solicit bids for a vehicle over the data communication network and to receive one or more bids for the vehicle. The valuation module is configured to set a salvage value of the vehicle based on at least one of the received bids. In some examples, the received bids include a high bid, and the valuation module is configured to set the salvage value approximately equal to the high bid. In some examples, the bid module is configured to solicit virtual bids in real time over the data communication network.

Abstract: The present invention relates to potentiators of metabotropic glutamate receptor function and specifically provides compounds of formula I, compositions thereof and methods of using the same.

Abstract: The present invention relates to potentiators of metabotropic glutamate receptor function and specifically provides compounds of formula I, compositions thereof and methods of using the same.

Abstract: The present invention provides a method of treating or preventing migraine comprising administering to a patient in need thereof an effective amount of a selective iGluR5 receptor antagonist. The present invention further provides novel compounds functional as selective iGluR5 receptor antagonists as well as compositions and formulations comprising said selective iGluR5 receptor antagonists.

Abstract: This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

Abstract: This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT.sub.1F agonist.

Abstract: This invention provides a method for the treatment or amelioration of the symptoms of venomous bites or stings which comprises administering to a mammal in need thereof one or more 5-HT.sub.2 antagonists.

Abstract: This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a 5-HT.sub.2 antagonist.