Patents by Inventor Willy Haefely

Willy Haefely has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing imidazodiazepines
    Patent number: 4363762
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of: ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: December 14, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Thieno-1,4-diazepin-5-ones and benzo-1,4-diazepin-5-ones
    Patent number: 4359420
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: November 16, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Thienodiazepinone and benzodiazepinone intermediates
    Patent number: 4346033
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Imidazodiazepine derivatives
    Patent number: 4346030
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Imidazodiazepine derivatives
    Patent number: 4346032
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Process for preparing imidazodiazepines
    Patent number: 4346035
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Process for preparing imidazodiazepines
    Patent number: 4346034
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is <C.dbd.O or <C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Process for preparing imidazodiazepine derivatives
    Patent number: 4346036
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Process for preparing imidazodiazepines
    Patent number: 4346031
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Imidazodiazepine derivatives
    Patent number: 4316839
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: October 3, 1980
    Date of Patent: February 23, 1982
    Assignee: Hoffman-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Antidepressant compositions
    Patent number: 3932652
    Abstract: Pharmaceutical compositions active in the therapeutic treatment of depression and insomnia and containing a synergistic mixture of L-5-hydroxy-tryptophan or a pharmaceutically acceptable salt thereof and N.sup.1 -(D,L-seryl)-N.sup.2 -(2,3,4-trihydroxybenzyl)-hydrazine or a pharmaceutically acceptable salt thereof are disclosed.
    Type: Grant
    Filed: February 27, 1975
    Date of Patent: January 13, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Willy Haefely