Abstract: Mobile three-dimensional (3D) cadmium-zinc-telluride (CZT) radiation imager with aperture masks provide improved imaging speed and visual depth imaging capabilities, making the disclosed solutions suitable at least for intraoperative medical applications. A 3D CZT imager includes a plurality of CZT crystals configured to generate charge in response to incident radiation emitted from a radiated area within a portion of the anatomical body and one or more electrodes configured to collect the charge generated from the incident radiation and induce electrical signals in response to the collected charge. The 3D CZT imager further includes an aperture mask positioned between the plurality of CZT crystals and the radiation source/target being imaged. The mask includes openings being designed or configured for particular projections of a radiation distribution onto the plurality of CZT crystals. Solutions disclosed herein can generate localized 3D radiation image reconstructions in real-time or near real-time.