Patents by Inventor Willy Leimgruber

Willy Leimgruber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrroles and pyrrolidines
    Patent number: 4316847
    Abstract: The preparation of racemic and optically pure tryptophans is described. The D-enantiomers of the 6-substituted compounds possess a potent sweetening capability. Novel intermediates are also disclosed.
    Type: Grant
    Filed: October 22, 1980
    Date of Patent: February 23, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew D. Batcho, Urs O. Hengartner, Willy Leimgruber, John W. Scott, Donald Valentine, Jr.
  • Novel syntheses of tryptophans
    Patent number: 4256641
    Abstract: The preparation of racemic and optically pure tryptophans is described. The D-enantiomers of the 6-substituted compounds possess a potent sweetening capability. Novel intermediates are also disclosed.
    Type: Grant
    Filed: July 30, 1979
    Date of Patent: March 17, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew D. Batcho, Urs O. Hengartner, Willy Leimgruber, John W. Scott, Donald Valentine, Jr.
  • Fluorogenic materials and labeling techniques
    Patent number: 4238589
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: December 9, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Synthesis of tryptophans
    Patent number: 4198501
    Abstract: A process is disclosed for preparing racemic and optically pure tryptophans through novel intermediates.
    Type: Grant
    Filed: October 30, 1978
    Date of Patent: April 15, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew D. Batcho, Willy Leimgruber
  • Lower alkyl esters of .alpha.-formamido,.alpha.-carbalkoxy tryptophans
    Patent number: 4140697
    Abstract: Lower alkyl esters of 2-formamido-3(4,5,6 or 7-methyl substituted-3-indolyl)-2-carbalkoxy propionic acid which are useful as intermediates for tryptophane sweetners.
    Type: Grant
    Filed: November 9, 1977
    Date of Patent: February 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew D. Batcho, Urs O. Hengartner, Willy Leimgruber, John W. Scott, Donald Valentine, Jr.
  • Process for the preparation of aldehydes
    Patent number: 4139720
    Abstract: A multi-step process for the preparation of alpha,beta-unsaturated aliphatic aldehydes such as citral by first reacting an allylic alcohol with a butadienyl ether, or a corresponding acrolein derivative or its acetal, including novel intermediates in this process.
    Type: Grant
    Filed: November 16, 1977
    Date of Patent: February 13, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Donald H. Valentine, Jr.
  • Synthesis of tryptophans
    Patent number: 4137404
    Abstract: A process is disclosed for preparing racemic and optically pure tryptophans through novel intermediates.
    Type: Grant
    Filed: December 20, 1977
    Date of Patent: January 30, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew D. Batcho, Willy Leimgruber
  • Process for the preparation of aldehydes
    Patent number: 4123464
    Abstract: A multi-step process for the preparation of alpha,beta-unsaturated aliphatic aldehydes such as citral by first reacting an allylic alcohol with a butadienyl ether, or a corresponding acrolein derivative or its acetal, including novel intermediates in this process.
    Type: Grant
    Filed: December 30, 1976
    Date of Patent: October 31, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Donald H. Valentine, Jr.
  • Process for the preparation of aldehydes
    Patent number: 4073811
    Abstract: A multi-step process for the preparation of alpha,beta-unsaturated aliphatic aldehydes such as citral by first reacting an allylic alcohol with a butadienyl ether, or a corresponding acrolein derivative or its acetal, including novel intermediates in this process.
    Type: Grant
    Filed: December 30, 1976
    Date of Patent: February 14, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Donald H. Valentine, Jr.
  • Synthesis of tryptophans
    Patent number: 4073795
    Abstract: The preparation of racemic and optically pure tryptophans is described. The D-enantiomers of the 6-substituted compounds possess a potent sweetening capability. Novel intermediates are also disclosed.
    Type: Grant
    Filed: June 22, 1976
    Date of Patent: February 14, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew David Batcho, Urs Oskar Hengartner, Willy Leimgruber, John William Scott, Donald Valentine, Jr.
  • 1-Dimethylamino-2,4-diphenyl-1-butene-3,4-dione
    Patent number: 4045487
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: August 30, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Certain 2-hydroxy-2,4-diaryl-3-furanones
    Patent number: 4038289
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl: R.sub.2 is phenyl or substituted phenyl: and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: July 26, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Fluorogenic materials and labeling techniques
    Patent number: 4018884
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl: R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: April 19, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Process for the preparation of aldehydes
    Patent number: 4016212
    Abstract: A multi-step process for the preparation of alpha,beta-unsaturated aliphatic aldehydes such as citral by first reacting an allylic alcohol with a butadienyl ether, or a corresponding acrolein derivative or its acetal, including novel intermediates in this process.
    Type: Grant
    Filed: February 15, 1974
    Date of Patent: April 5, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Donald Herman Valentine, Jr.
  • Intermediates for indoles
    Patent number: 3976639
    Abstract: Ortho-nitrotoluenes are condensed with formamide acetals to yield the corresponding otho-nitro-.beta.-aminestyrenes which undergo cyclization upon reduction to yield indoles.
    Type: Grant
    Filed: March 31, 1975
    Date of Patent: August 24, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew David Batcho, Willy Leimgruber
  • Fluorogenic 2-oxy-3(2H)-furanone materials
    Patent number: 3969373
    Abstract: Compounds of the formula ##SPC1##Wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: June 26, 1975
    Date of Patent: July 13, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Preparation of dialkyl amino acrylonitrile
    Patent number: 3966791
    Abstract: A process for preparing dialkyl amino acrylonitrile by condensing acetonitrile and an acetal of dimethyl formamide. The dialkyl amino acrylonitrile is an intermediate for aminomethylene malononitrile, a valuable intermediate for thiamine.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: June 29, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Manfred Weigele
  • Process for producing dialkyl aminoacrylonitrile
    Patent number: 3965141
    Abstract: A process for producing a dialkyl aminoacrylonitrile by treating dimethylaminopropionitrile with a hydrogen acceptor in the presence of a dehydrogenation catalyst. The dialkylaminoacrylonitrile thus produced is converted to aminomethylene malonitrile, a known intermediate for thiamine.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: June 22, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Manfred Weigele
  • Spirolactone production
    Patent number: 3957826
    Abstract: A novel class of reagents react with primary amine-containing compounds, preferably polypeptides and amino acids, to form highly fluorescent products. This reaction serves as a basis for a rapid and highly sensitive assay method for primary amine-containing compounds.
    Type: Grant
    Filed: May 23, 1975
    Date of Patent: May 18, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Manfred Weigele
  • 6-Substituted 1-phenazinol 5,10-dioxide derivatives
    Patent number: 3937707
    Abstract: 6-Substituted derivatives of 1-phenazinol 5,10-dioxide which possess broad spectrum anti-microbial activity are disclosed.
    Type: Grant
    Filed: July 22, 1974
    Date of Patent: February 10, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Manfred Weigele