Patents by Inventor Willy SOLIS

Willy SOLIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOMODULATOR ANTIBODY DRUG CONJUGATES AND USES THEREOF
    Publication number: 20240139285
    Abstract: Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases
    Type: Application
    Filed: May 30, 2023
    Publication date: May 2, 2024
    Inventors: Alice YAM, Andreas MADERNA, Cristina ABRAHAMS, Willy SOLIS, Xiaofan LI, Ryan STAFFORD, Gang YIN, Venita DE ALMEIDA, Krishna BAJJURI, Adam A. GALAN
  • HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA-GAMMAC DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER
    Publication number: 20240101631
    Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.
    Type: Application
    Filed: October 11, 2023
    Publication date: March 28, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
  • Human interleukin-2 conjugates biased for the interleukin-2 receptor beta GAMMAc dimer and conjugated to a nonpeptidic, water-soluble polymer
    Patent number: 11827684
    Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.
    Type: Grant
    Filed: April 20, 2021
    Date of Patent: November 28, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
  • Immunomodulator antibody drug conjugates and uses thereof
    Patent number: 11744876
    Abstract: Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: September 5, 2023
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Alice Yam, Andreas Maderna, Cristina Abrahams, Willy Solis, Xiaofan Li, Ryan Stafford, Gang Yin, Venita De Almeida, Krishna Bajjuri, Adam A. Galan
  • HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA GAMMAc DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER
    Publication number: 20210340207
    Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.
    Type: Application
    Filed: April 20, 2021
    Publication date: November 4, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
  • IMMUNOMODULATOR ANTIBODY DRUG CONJUGATES AND USES THEREOF
    Publication number: 20200405813
    Abstract: Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases
    Type: Application
    Filed: June 10, 2020
    Publication date: December 31, 2020
    Inventors: Alice YAM, Andreas MADERNA, Cristina ABRAHAMS, Willy SOLIS, Xiaofan LI, Ryan STAFFORD, Gang YIN, Venita DE ALMEIDA, Krishna BAJJURI, Adam A. GALAN