Patents by Inventor WILMA LAU

WILMA LAU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-BRDU ANTIBODIES AND METHODS OF USE
    Publication number: 20240043564
    Abstract: The invention provides anti-BRDU antibodies and methods of using the same.
    Type: Application
    Filed: May 1, 2023
    Publication date: February 8, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich BRINKMANN, Guy GEORGES, Johannes AUER, Wilma LAU
  • FAB HIGH MANNOSE GLYCOFORMS
    Publication number: 20240002483
    Abstract: The present invention relates to glycosylation patterns at the Fab portion of a monoclonal antibody and methods for the regulation during culture of a microorganism expressing a monoclonal antibody with regulated content of high mannose Fab glycoforms.
    Type: Application
    Filed: November 4, 2021
    Publication date: January 4, 2024
    Inventors: Klaus JOERIS, Neslihan OEZDEN, Wolfgang RICHTER, Britta SCHMIDT, Carsten HOFMANN, Wilma LAU, Roland STAACK
  • Anti-BRDU antibodies and methods of use
    Patent number: 11673968
    Abstract: The invention provides anti-BRDU antibodies and methods of using the same.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: June 13, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Guy Georges, Johannes Auer, Wilma Lau
  • ANTI-BRDU ANTIBODIES AND METHODS OF USE
    Publication number: 20200002437
    Abstract: The invention provides anti-BRDU antibodies and methods of using the same.
    Type: Application
    Filed: March 5, 2019
    Publication date: January 2, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Guy Georges, Johannes Auer, Wilma Lau
  • Bispecific antibodies
    Patent number: 10106600
    Abstract: The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: October 23, 2018
    Assignee: Roche Glycart AG
    Inventors: Ulrich Brinkmann, Rebecca Croasdale, Harald Duerr, Christian Klein, Erhard Kopetzki, Wilma Lau, Joerg Thomas Regula, Juergen Michael Schanzer, Pablo Umana, Katharina Wartha
  • ANTI-BRDU ANTIBODIES AND METHODS OF USE
    Publication number: 20170114150
    Abstract: The invention provides anti-BRDU antibodies and methods of using the same.
    Type: Application
    Filed: December 16, 2016
    Publication date: April 27, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich BRINKMANN, Guy GEORGES, Johannes AUER, Wilma LAU
  • Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
    Patent number: 9574016
    Abstract: The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: February 21, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Rebecca Croasdale, Wilma Lau, Guy Georges, Alexander Haas, Eike Hoffmann, Silke Metz, Olaf Mundigl, Werner Scheuer, Jan Olaf Stracke
  • Method for reduction of 1->2 reading frame shifts
    Patent number: 9487576
    Abstract: Herein is reported a method for the recombinant production of a polypeptide, which comprises the dipeptide AR, characterized in that the method comprises the recovering of the polypeptide from the cells or the cultivation medium of a cultivation of a cell comprising a nucleic acid encoding the polypeptide and thereby producing the polypeptide, whereby the dipeptide AR comprised in the polypeptide is encoded by the oligonucleotide gca cgt, or the oligonucleotide gcg cgt, or the oligonucleotide gcc cgt.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: November 8, 2016
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Adelbert Grossmann, Friederike Hesse, Erhard Kopetzki, Wilma Lau, Christian Schantz
  • METHOD FOR REDUCTION OF 1->3 READING FRAME SHIFTS
    Publication number: 20150064746
    Abstract: Herein is reported a method for the recombinant production of a polypeptide, which comprises the tripeptide QKK, characterized in that the method comprises the step of recovering the polypeptide from the cells or the cultivation medium of a cultivation of a cell comprising a nucleic acid encoding the polypeptide and thereby producing the polypeptide, whereby the tripeptide QKK comprised in the polypeptide is encoded by the oligonucleotide cag aaa aaa or the oligonucleotide caa aag aaa.
    Type: Application
    Filed: August 29, 2014
    Publication date: March 5, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Adelbert Grossmann, Friederike Hesse, Erhard Kopetzki, Wilma Lau, Christian Schantz
  • METHOD FOR REDUCTION OF 1->2 READING FRAME SHIFTS
    Publication number: 20150056656
    Abstract: Herein is reported a method for the recombinant production of a polypeptide, which comprises the dipeptide AR, characterized in that the method comprises the recovering of the polypeptide from the cells or the cultivation medium of a cultivation of a cell comprising a nucleic acid encoding the polypeptide and thereby producing the polypeptide, whereby the dipeptide AR comprised in the polypeptide is encoded by the oligonucleotide gca cgt, or the oligonucleotide gcg cgt, or the oligonucleotide gcc cgt.
    Type: Application
    Filed: August 29, 2014
    Publication date: February 26, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Adelbert Grossmann, Friederike Hesse, Erhard Kopetzki, Wilma Lau, Christian Schantz
  • Prokaryotic expression construct
    Patent number: 8877895
    Abstract: A pro-polypeptide which is useful for the expression of a polypeptide of interest in a prokaryotic cell. Therefore the pro-polypeptide is fused to the N-terminus of the polypeptide of interest. The pro-polypeptide as reported herein provides for improved expression yields and improves the handling of the fusion polypeptide (downstream processing, purification). For example, efficient endotoxin removal is effected while the protein of interest comprising the pro-polypeptide is bound e.g. to an affinity chromatography material. Thereafter the pro-polypeptide can efficiently be cleaved from the polypeptide of interest by the incorporated protease cleavage site with the cognate protease.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: November 4, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Adelbert Grossmann, Friederike Hesse, Erhard Kopetzki, Wilma Lau, Christian Schantz
  • PROKARYOTIC EXPRESSION CONSTRUCT
    Publication number: 20120214200
    Abstract: A pro-polypeptide which is useful for the expression of a polypeptide of interest in a prokaryotic cell. Therefore the pro-polypeptide is fused to the N-terminus of the polypeptide of interest. The pro-polypeptide as reported herein provides for improved expression yields and improves the handling of the fusion polypeptide (downstream processing, purification). For example, efficient endotoxin removal is effected while the protein of interest comprising the pro-polypeptide is bound e.g. to an affinity chromatography material. Thereafter the pro-polypeptide can efficiently be cleaved from the polypeptide of interest by the incorporated protease cleavage site with the cognate protease.
    Type: Application
    Filed: August 25, 2011
    Publication date: August 23, 2012
    Inventors: Adelbert Grossmann, Friedrich Hesse, Erhard Kopetzki, Wilma Lau, Christian Schantz
  • BISPECIFIC ANTIBODIES
    Publication number: 20110293613
    Abstract: The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Application
    Filed: March 24, 2011
    Publication date: December 1, 2011
    Inventors: ULRICH BRINKMANN, REBECCA CROASDALE, HARALD DUERR, CHRISTIAN KLEIN, ERHARD KOPETZKI, WILMA LAU, JOERG THOMAS REGULA, JUERGEN MICHAEL SCHANZER, PABLO UMAÑA, KATHARINA WARTHA