Patents by Inventor Wilson Harvey
Wilson Harvey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20090035313Abstract: This invention relates to nicotinamide derivatives of general formula (I): in which R1, Z and R2 have the meanings defined herein, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of such derivatives.Type: ApplicationFiled: July 13, 2004Publication date: February 5, 2009Inventors: Christohper Gordon Barber, Mark Edward Bunnage, John Wilson Harvey, John Paul Mathias
-
Patent number: 6440940Abstract: The invention provides oxidized alginates that are bioresorbable. The oxidized alginates are prepared by controlled oxidation of alginates with nitrogen tetroxide or the like, The invention also provides pharmaceutical compositions, wound dressings, surgical implants and prostheses comprising the oxidized alginate derivatives.Type: GrantFiled: December 18, 1997Date of Patent: August 27, 2002Inventors: Peter J. Doyle, Wilson Harvey, Reginald L. Stilwell
-
Patent number: 6106855Abstract: Stable oil-in-water emulsions are prepared by mixing oil, water and an insoluble protein at high shear. By varying the amount of insoluble protein the emulsions may be made liquid, semisolid or solid. The preferred insoluble proteins are insoluble fibrous proteins such as collagen. The emulsions may be medicated with hydrophilic or hydrophobic pharmacologically active agents and are useful as or in wound dressings or ointments.Type: GrantFiled: March 22, 1993Date of Patent: August 22, 2000Assignee: Johnson & Johnson Medical, Inc.Inventors: Carla A. Haynes, Wilson Harvey
-
Patent number: 6015844Abstract: A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidised regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.Type: GrantFiled: December 19, 1997Date of Patent: January 18, 2000Assignee: Johnson & Johnson Medical, Inc.Inventors: Wilson Harvey, Nicholas D. Light, Carla A. Haynes
-
Patent number: 6001895Abstract: A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidized regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.Type: GrantFiled: December 19, 1997Date of Patent: December 14, 1999Assignee: Johnson & Johnson Medical, Inc.Inventors: Wilson Harvey, Nicholas D. Light, Carla A. Haynes
-
Patent number: 5869080Abstract: Absorbable implant materials having controlled porosity are formed by a method comprising the steps of: providing a dispersion of a bioabsorbable polymer, such as collagen, in a first solvent, such as water; adding particles of a second material, e.g. frozen water droplets or ice particles to the dispersion; followed by freezing the dispersion to form a frozen dispersion having the particles embedded therein, and removing both the first solvent and the second material from the frozen dispersion by freeze-drying or solvent extraction to leave the porous implant material. The invention also encompasses the use of such implant materials for wound healing applications.Type: GrantFiled: May 28, 1996Date of Patent: February 9, 1999Assignee: Johnson & Johnson Medical, Inc.Inventors: James McGregor, Paul W. Watt, Nicholas D. Light, Wilson Harvey
-
Patent number: 5789465Abstract: A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidized regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.Type: GrantFiled: July 27, 1994Date of Patent: August 4, 1998Assignee: Johnson & Johnson Medical, Inc.Inventors: Wilson Harvey, Nicholas D. Light, Carla A. Haynes
-
Patent number: 5660857Abstract: A process for preparing a composite comprising an insoluble protein matrix and an oleaginous material, which is useful as a material for surgical dressings and biomedical implants, and as a cosmetic material for application to the skin. The process comprises the steps of mixing a protein, the oleaginous material and water to form an emulsion of the oleaginous material in an aqueous dispersion of the protein, and subsequently drying or freeze-drying the emulsion to form a film or a sponge.Type: GrantFiled: May 10, 1995Date of Patent: August 26, 1997Assignee: Johnson & Johnson Medical Inc.Inventors: Carla A. Haynes, Wilson Harvey, Paul W. Watt
-
Patent number: 5611793Abstract: A method of disinfecting or sterilizing tissues of the oral cavity or a wound or lesion in the oral cavity is provided. The method comprises applying a photosensitizing compound to said tissues, wound or lesion and irradiating said tissues, wound or lesion with laser light at a wavelength absorbed by said photosensitizing compound.Type: GrantFiled: October 25, 1994Date of Patent: March 18, 1997Assignee: Institute of Dental SurgeryInventors: Michael Wilson, Wilson Harvey
-
Patent number: 5595621Abstract: A fully absorbable prosthesis (1) for the repair of damaged ligaments and/or tendons in the form of a multilayer spiral roll comprising the following spiral layers: a foraminous layer (2) of a synthetic bioabsorbable material; a bioabsorbable film (3); and a layer (4) of a bioabsorbable biopolymer sponge. The invention also provides a method of making such a prosthesis, comprising the steps of: providing a laminate of a foraminous layer of bioabsorbable material and a bioabsorbable film; coating the laminate with a layer of an aqueous gel comprising a bioabsorbable polymer; rolling up the laminate and the gel layer into a spiral roll, followed by drying the gel to form a layer of bioabsorbable sponge. The foraminous layer (2) preferably comprises a synthetic bioabsorbable polymer having high tensile strength. The bioabsorbable film (3) and sponge layer (4) preferably comprise a chemotactic biopolymer such as collagen.Type: GrantFiled: June 7, 1995Date of Patent: January 21, 1997Assignee: Johnson & Johnson Medical, Inc.Inventors: Nicholas D. Light, James McGregor, Wilson Harvey, Paul W. Watt
-
Patent number: 5514181Abstract: A fully absorbable prosthesis (1) for the repair of damaged ligaments and/or tendons in the form of a multilayer spiral roll comprising the following spiral layers: a foraminous layer (2) of a synthetic bioabsorbable material; a bioabsorbable film (3); and a layer (4) of a bioabsorbable biopolymer sponge. The invention also provides a method of making such a prosthesis, comprising the steps of: providing a laminate of a foraminous layer of bioabsorbable material and a bioabsorbable film; coating the laminate with a layer of an aqueous gel comprising a bioabsorbable polymer; rolling up the laminate and the gel layer into a spiral roll, followed by drying the gel to form a layer of bioabsorbable sponge. The foraminous layer (2) preferably comprises a synthetic bioabsorbable polymer having high tensile strength. The bioabsorbable film (3) and sponge layer (4) preferably comprise a chemotactic biopolymer such as collagen.Type: GrantFiled: September 29, 1994Date of Patent: May 7, 1996Assignee: Johnson & Johnson Medical, Inc.Inventors: Nicholas D. Light, James MacGregor, Wilson Harvey, Paul W. Watt
-
Patent number: 5447940Abstract: Absorbable composite materials are described that comprise a collagen matrix reinforced with a layer of a bioabsorbable polymer. A chemotherapeutic agent is dispersed in the composite material. The layer of bioabsorbable polymer is preferably a woven, nonwoven or knitted mesh layer of a synthetic bioabsorbable polymer such as polylactic/polyglycolic acid copolymer, or oxidised regenerated cellulose. The chemotherapeutic agent may be an antibiotic, an anaesthetic, an antiseptic or an anti-inflammatory. Strips of the composite material are inserted into the periodontal pocket, where they are retained in place and provide effective sustained release of the chemotherapeutic agent over an extended period.Type: GrantFiled: July 27, 1994Date of Patent: September 5, 1995Assignee: Johnson & Johnson Medical, Inc.Inventors: Wilson Harvey, Nicholas D. Light, Carla A. Haynes
-
Patent number: 5192362Abstract: To combat the accumulation of plaque on dentures, a non self-supporting coating of a non-toxic, negatively charged polysaccharide is applied. The polysaccharide coating is gradually sacrificed or ablated during wear. Ablation appears to remove microorganisms along with coating material. The polysaccharide is further defined by an ability to reduce the adhesion of Streptococcus salivarius cells in a simple in vitro bacterial adhesion test by at least 25% over a control.Type: GrantFiled: July 29, 1991Date of Patent: March 9, 1993Assignee: National Research Development CorporationInventors: Wilson Harvey, Michael Wilson
-
Patent number: 5087451Abstract: Periodontal disease is treated with a composition comprising a topically-retainable carrier such as an alginate gel and a non-toxic electron acceptor, such as a ferric compound or a redox organic dye, especially methylene blue or patent blue V, which does not supply molecular oxygen.Type: GrantFiled: March 7, 1988Date of Patent: February 11, 1992Assignee: National Research Development CorporationInventors: Michael Wilson, Wilson Harvey