Abstract: Controlling an in-flight spin-rate of a spin-stabilized guided projectile is disclosed. In various embodiments, the projectile includes a despun control portion configured for despinning relative to a projectile chassis and for directional control of the projectile. In various embodiments, controlling the in-flight spin-rate includes determining a gyroscopic stability factor for the guided projectile using the in-flight spin rate and a forward velocity of the guided projectile, determining that the gyroscopic stability factor exceeds a stability threshold, and spin-braking the guided projectile, in response to determining that the gyroscopic stability factor exceeds a threshold value, by braking rotation of the despun control portion by which the gyroscopic stability factor of the guided projectile is reduced to a second gyroscopic stability factor.

Abstract: Systems, methods and apparatuses to log memory errors in memory devices that can perform wear leveling based on physical addresses used in the memory devices to address select memory cells. For example, a controller of a memory sub-system communicates with a memory device installed in the memory sub-system to access memory cells in the memory device. During the communication to access memory cells in the memory device, the controller can determine a memory error at a first address. If the controller transmits the first address to the memory device for memory access at the time of the memory error, the memory device converts the first address to a second address to perform the memory access. The controller can be configured to determine the second address and record, in an error log, the memory error in association with the second address.

Abstract: Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. The disclosure provides fusion proteins of nucleic acid programmable DNA binding proteins (napDNAbp), e.g., Cas9 or variants thereof, and nucleic acid editing proteins such as cytidine deaminase domains (e.g., novel cytidine deaminases generated by ancestral sequence reconstruction), and adenosine deaminases that deaminate adenine in DNA. Aspects of the disclosure relate to fusion proteins (e.g., base editors) that have improved expression and/or localize efficiently to the nucleus. In some embodiments, base editors are codon optimized for expression in mammalian cells. In some embodiments, base editors include multiple nuclear localization sequences (e.g., bipartite NLSs), e.g., at least two NLSs.

Abstract: Certain aspects relate to systems and techniques for preparing a robotic system for surgery. In one aspect, the method includes a robotic arm, a sensor configured to generate information indicative of a location of the robotic arm, a processor, and at least one computer-readable memory in communication with the processor and having stored thereon computer-executable instructions. The instructions are configured to cause the processor to receive the information from the sensor, determine that the robotic arm is located at a first position in which a first axis associated with the robotic arm is not in alignment with a second axis associated with a port installed in a patient, and provide a command to move the robotic arm to a second position in which the first axis associated with the robotic arm is in alignment with the second axis.

Abstract: A high-voltage module, such as a traction battery, a traction inverter, or a DC/DC converter of a traction powertrain of an electrified vehicle (EV), includes an enclosure, an electronics assembly for performing electrical power operations, and a fuse box for providing a power distribution and fuse protection arrangement to the electronics assembly. The enclosure includes a main enclosure portion and a secondary enclosure portion integrated together. The electronics assembly is housed within the main enclosure portion and the fuse box is housed within the secondary enclosure portion.

Abstract: A method and system for bidirectional charging in an electric vehicle include controlling a multi-phase machine in the electric vehicle. In response to determining that a direction of energy flow is from an electric grid to the electric vehicle, the method and system include operating a first set of phases in the multi-phase machine at a grid frequency of the electric grid and connecting the first set of phases in the multi-phase machine to the electric grid. In response to connecting the first set of phases in the multi-phase machine to the electric grid, the method and system include operating a second set of phases in the multi-phase machine, where the second set of phases in the multi-phase machine generates energy via electrical coupling to the first set of phases in the multi-phase machine. The method and system also include providing the energy generated by the second set of phases in the multi-phase machine to charge an energy source of the electric vehicle.

Abstract: Aspects of the present disclosure relate generally to novel antigen binding sequences and uses thereof. More specifically, certain features of the present disclosure concern antibodies, minibodies, and cys-diabodies for use in targeting the protein FAP. The antigen binding sequences herein may be used as part of treatment to confer health benefits to subjects in need thereof. The antigen binding sequences can also be used for detection, targeting, and imaging purposes.

Abstract: Techniques for collecting, synchronizing, and displaying various types of data relating to a road segment enable, via one or more local or remote processors, servers, transceivers, and/or sensors, (i) enhanced and contextualized analysis of vehicle events by way of synchronizing different data types, relating to a monitored road segment, collected via various different types of data sources; (ii) enhanced and contextualized analysis of filed insurance claims pertaining to a vehicle incident at a road segment; (iii) advantageous machine learning techniques for predicting a level of risk assumed for a given vehicle event or a given road segment; (iv) techniques for accounting for region-specific driver profiles when controlling autonomous vehicles; and/or (v) improved techniques for providing a GUI to display collected data in a meaningful and contextualized manner.

Abstract: Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

Abstract: A milling machine can include a frame; a cutting rotor coupled to the frame, the cutting rotor configured to be lowered a selected distance into a first surface to define a depth of cut, the cutting rotor forming a cut surface; a sensor positioned to collect information regarding a quality of the cut surface behind the milling machine; and a controller coupled to the sensor to receive the information and configured to initiate an action to change the depth of cut in view of the information.

Abstract: A ratcheting mechanism composed of a housing that encloses a plurality of pins acting as pawls, engaging with a rack having teeth, wherein each of the pins acts independently, allowing for fine adjustments of the rack. An actuator enables seamless engagement and disengagement of the pins in relation to the rack. A sensor may be used to determine the location of at least one pin within the housing as it is related to the rack.

Abstract: A conductive cable for a battery electric vehicle is provided. The conductive cable comprises a plurality of first members in alignment to define a longitudinal axis of the conductive cable. Each first member comprises a first conductive wire about which a first outer layer is disposed for electric current to flow therethrough relative to the longitudinal axis. The first outer layer comprises a first metal substrate having a first side and an opposite second side. The first outer layer comprises a first copper-graphene (Cu-Gr) multilayer composite disposed on the first side and a second Cu-Gr multilayer composite disposed on the second side of the first metal substrate. Each first conductive wire comprises a first metallic material. The plurality of first members is disposed together along the longitudinal axis to define a cable bundle. The conductive cable further comprises a non-conductive layer disposed about the cable bundle.

Abstract: An antenna assembly is provided. The antenna assembly includes a parabolic reflector having a parabolic focal point and defining a boresight axis, a radio feed arranged on struts at the parabolic focal point and a calibration system. The calibration system includes a camera attached to the radio feed, a video feed displaying an image of an object generated by the camera, controls for centering the image in the video feed, an antenna rotator for aiming the parabolic reflector toward the object in accordance with the image being centered in the video feed and a controller. The calibration system is operable by first inputs to the controls that are reflected in the video feed and a second input to the controller to calibrate pointing of the parabolic reflector.

Abstract: A method of determining the time delay between echoes of an ultrasound pulse emitted by an ultrasound inspection device into an object, the method including: with the ultrasound probe in engagement with a front-wall feature of the object such that the ultrasound inspection device's ultrasound axis is arranged at an angle relative to the nominal surface normal of the front-wall feature, taking an ultrasound measurement which includes the ultrasound inspection device emitting an ultrasound pulse and recording echoes thereof; and determining the time delay between echoes of the pulse via a time delay determination process which adjusts the time delay calculation based on the angle of the ultrasound inspection device's ultrasound axis with respect to the nominal surface normal of the front-wall feature.

Abstract: Colored roofing granules comprising agglomerated inorganic material with embedded pigment, and building materials, such as roofing shingles, that include such colored roofing granules. By fabricating colored roofing granules from agglomerating inorganic material it is possible to tailor the particle size distribution so as to provide optimal shingle surface coverage, thus reducing shingle weight and usage of raw materials. Additionally, agglomeration of inorganic material with embedded pigment, including colored rock fines and/or colored mineral fines, permits the utilization of by-products from conventional granule production processes, including a waste stream of pigment.

Abstract: A method for sample preparation for antibiotic therapy guidance, stratification and/or control in a patient with one or more comorbidities comprising an impaired innate immune response and suspected of having an infection. Also, a method for sample preparation for antibiotic therapy guidance, stratification and/or control in a patient with one or more comorbidities comprising an impaired innate immune response. The method comprises providing a sample from said patient and determining a level of PCT or fragment(s) thereof in said sample, wherein the level of PCT or fragment(s) thereof in said sample is indicative of whether an initiation or a change of an antibiotic treatment is required.

Abstract: Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

Abstract: A system for assessing a damage condition of a vehicle and a platform for facilitating repairing or maintenance services of a vehicle. The system comprises a damage identification module arranged to identify the one or more damages captured in a set of input images showing at least a portion of the vehicle; a component identification module arranged to identify one or more damaged components of the vehicle with the identified damages thereon; and an output module arranged to generate a damage assessment report associated with the identified damages and/or the identified damaged components of the vehicle.

Abstract: Genetically engineered hematopoietic cells, which express one or more factors that redirect glucose metabolites, and optionally a chimeric receptor polypeptide (e.g., an antibody-coupled T cell receptor (ACTR) polypeptide, a chimeric antigen receptor (CAR) polypeptide, or a TCR polypeptide) capable of binding to a target antigen of interest. Also disclosed herein are uses of the engineered hematopoietic cells for inhibiting cells expressing a target antigen in a subject in need thereof.