Abstract: The present disclosure provides a compound represented by structural Formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.

Abstract: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

Abstract: A substrate retaining apparatus, a load lock assembly comprising the substrate retaining apparatus, and a system including the substrate retaining apparatus are disclosed. The substrate retaining apparatus can include at least one sidewall and one or more heat shields. One or more of the at least one sidewall can include a cooling fluid conduit to facilitate cooling of substrates retained by the substrate retaining apparatus. Additionally or alternatively, one or more of the at least one sidewall can include a gas conduit to provide gas to a surface of a retained substrate.

Abstract: Improved cell culture devices and related methods that overcome the limitations of prior devices and methods, by creating devices that can integrate a variety of novel attributes. These various attributes include the use of gas permeable material and medium volumes that exceed conventional devices as well as compartments that can facilitate the long term study of high density cultures with reduced disruption of the culture environment, the ability to study the migration of items of interest including substances such as chemokine, track the movement of cells, and monitor cell to cell interactions.

Abstract: This application describes a magnetic valve for controlling the flow of media in wheel-blast style abrasive blasting cabinets. The valve features a novel air aspiration system comprising of aspiration inlets, chamber, and outlets, in a configuration which guarantees passage of air from ambient into the peening system regardless of installation. This system acts as a passive aspiration source to counteract the negative pressures imposed by the wheel-blast blades in the valve's off-state. This arrangement eliminates the need for other means of aspiration to be installed in the peening system by the end user.

Abstract: A method for tuning a distributed acoustic sensing (DAS) system. The method may include determining a signal strength from a first Raman Pump in the DAS system, sweeping a laser pulse output from a transmitter; wherein the sweeping is an incremental increase of a power of the laser pulse output from a minimum pulse power to a maximum pulse power, and measuring a first signal-to-noise-ratio (SNR) for each of the incremental increase of the power of the laser pulse output. The method may further comprise selecting a maximum SNR from the first SNR for each of the incremental increase of the power of the laser pulse output and configuring the first Raman Pump and the laser pulse output based at least in part on the maximum SNR.

Abstract: A valve for regulating the flow of ferromagnetic peening materials, consisting of an arrangement of pole pieces, spacers, permanent magnets, and electrical coils. This arrangement uses an angular magnetic field to concentrate holding strength within the working gaps without sacrificing holding strength to the environment, increasing the valve's efficiency. Additionally, this valve covers a large range of flow rates by exchanging center bars and magnets of different sizes, without otherwise increasing the size of the valve.

Abstract: The present disclosure provides nucleic acid constructs and cell compositions for transcriptionally modifying a bacterial population within the gastrointestinal tract of a subject, and methods of use thereof.

Abstract: Semiconductive tapes for use with electric cables, such as high voltage power cables, and methods for manufacturing such tapes, are provided. A semiconductive tape comprises a first layer comprising a fabric and a second layer in contact with the first layer. The second layer comprises an activated carbon or carbon black. The semiconductive tapes have increased friction while still maintaining sufficient electrical conductivity for use as wrappings for electric power cables, thereby improving the manufacturing process and reducing the overall cost of production.

Abstract: A sheet of polymeric material is made using an extruding process and articles are formed from the sheet of polymeric material. The sheet of polymeric material and the articles comprise one or more polypropylene resins. In some embodiments, the sheet of polymeric material and the articles formed form the sheet of polymeric material are transparent.

Abstract: A laminous processed manway cover gasket includes an insert and a plurality of ePTFE layers of membranes wrapping the insert to result in isolation of the insert. In example, the isolation may result from a laminous, thermo-mechanical process that fuses together each ePTFE layer of membrane of the plurality of ePTFE layers of membranes.

Abstract: The present disclosure provides an optomechanical accelerometer that includes a first membrane having a first susceptibility; a second membrane having a second susceptibility that is greater than the first susceptibility; and at least one support member; wherein: the second membrane is supported above the first membrane by the at least one support member, such that the first and second membranes form at least a portion of an optical cavity.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof and solvates of any of the foregoing capable of inhibiting protein kinase A and/or its mutants, pharmaceutical compositions comprising at least one of the compounds, pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, processes for making the compounds, pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, and methods of using the same.

Abstract: A camera includes a camera housing and an objective carrier assembly having a carrier where a camera objective and a camera sensor are mounted. A method for manufacturing the camera includes aligning the objective carrier assembly in relation to a first housing part of the camera housing. The method includes mounting the objective carrier assembly over the first housing part in an aligned position. The method includes mounting a second housing part on the first housing part.

Abstract: A sacrificial media shield to be used in flow control valves in high volume wheel blast peening machines, comprised from a wear resistant material. This shield is intended to prevent undesired wear to the valve and its components via an offset arrangement, which isolates the majority of contact with the abrasive media stream to the media shield. This prevents plastic contamination within the media stream. Being a replaceable component, the shield extends the operating life of the valve by avoiding replacement of the valve in its entirety.

Abstract: A turbomachine component has a wall outer surface and an internal coolant source. A film-cooling hole is in the wall and extends from the internal coolant source to the wall outer surface. The film-cooling hole includes a metering section in fluid communication with the internal coolant source, and a diffuser section in fluid communication with the metering section and including a first internal surface spaced from a second internal surface. A coating collector receives part of a coating and is part of the diffuser section. The film-cooling hole also includes a hood section including a member extending outwardly from the wall outer surface. The member may include a hood internal surface contiguous with the first internal surface of the diffuser section and a hood outer surface parallel to the wall outer surface. The hood section reduces, and possibly prevents, the coating from filling the film-cooling hole during application thereof.

Abstract: An in vitro expansion process for rapid expansion of antigen specific T cells, such as allogeneic antigen specific T cells comprising the steps culturing in a gas permeable vessel a population of PBMCs (such as allogeneic PBMCs) in the presence of antigen, for example a peptide or peptide mix relevant to a target antigen(s), in the presence of an exogenous cytokine characterized in that the expansion to provide the desired population of T cells is 14 days or less, for example 9, 10, 11 or 12 days, such as 10 days. The disclosure also extends to T cell populations generated by and obtained from the method and the use of same in therapy.

Abstract: A shear coupling can be used with reciprocating and rotary pumps. The shear coupling uses a shear nut and connecting member as the shear element. The connecting member and shear nut are located inside the axial bore of the shear coupling to protect from corrosive wellbore elements. The coupling members may be connected by matching polygonal shaft and hub profiles on the coupling members to transmit torque. The shaft and hub may have octagonal profiles for better torque transmission capacity. The shear nut may be isolated from large alternating stresses due to pretensioning of the connecting member. The length of the connecting member, especially when pretensioned, and a reduced cross-section that may be formed on the outer surface of the shear coupling increase the overall flexibility of the shear coupling, thereby increasing the resistance to bending stress.

Abstract: Systems and methods are provided for adaptive data replication. A first data object is stored. One or more first network characteristics of a communication network are detected. A first replication mode is triggered (e.g., a single-master replication mode) based on the one or more first network characteristics of the communication network. The single-master replication may be configured to facilitate real-time synchronizations (e.g., for critical updates). One or more second network characteristics of the communication network are detected. A second replication mode (e.g., a multi-master replication mode) is triggered based on the one or more second network characteristics. The second replication may be configured to facilitate a delayed synchronization (e.g., for non-critical updates) of the first data object and the second data object using the second update file.

Abstract: This invention, in embodiments, relates to non-asphaltic coatings for roofing materials, to roofing materials made therefrom and to methods of preparing such coatings and roofing materials. By blending thermoplastic polymers with appropriate fillers and/or recycled materials, a composition is produced that can be pressed into a desired shape, or that can be additionally mixed with oils, resins and/or waxes to provide a liquid that can be poured onto an appropriate substrate.