Abstract: A method of detecting lung cancer in a subject involves: a) determining in a serum sample, the expression level of one or more miRNAs; b) determining in a urine sample, the concentration of one or more metabolites; c) comparing the expression level of the one or more miRNAs with the expression level of the one or more miRNAs in a normal control; d) comparing the concentration of the one or more metabolites with the concentration of the one or more metabolites in a normal control; e) determining whether the subject has lung cancer in accordance with the result of steps (c) and (d); wherein a difference in the expression level of the one or more miRNAs relative to the expression level of the normal control, and a difference in the concentration of the one or more metabolites relative to the concentration of the normal control, are indicative of lung cancer; and f) treating the subject with a cancer management program based on the determination in step (e).

Abstract: The present invention is directed to sputum microRNA expression profiles associated with lung cancer and methods of using same for screening a subject for the disease.

Abstract: The invention provides modified gold nanoparticles that enable a non-invasive, real time, targeted cancer imaging-therapeutic in one step. After reaching the cancer targets, the designed targeted gold nanoparticles significantly enhance conventional treatment modalities at the cellular level. In this aspect the gold nanoparticles of the invention are modified to be bound to a Positron Emission Tomography (PET) tracer.

Abstract: Effervescent powders comprising inhalable particles are disclosed, as are methods for preparing these powders. The inhalable carrier particles comprise an inorganic or organic carbonate, and an acid, and exhibit effervescence when exposed to water or humid air. The particles have a mass median aerodynamic diameter suitable for nasal, bronchial, or pulmonary administration. The inhalable particles may be used as carriers for active agents. The inhalable particles may also be used to enhance permeability of mucosal and surface barriers on an inner surface of the nose, mouth, airway, and/or lungs of a patient, as well as to loosen, thin, cleanse, and remove mucus and extrinsic surface materials from an inner surface of the nose, mouth, airway, and/or lungs of a patient in need thereof.

Abstract: Respirable particles carrying active principles or diagnostics in nanoparticle form are created by mixing the nanoparticles with liquid carrier, then forming the resultant mixture into respirable particles. Spray-drying, freeze spray drying and drying followed by comminution may be used to create the respirable particles, which may be delivered to the lung via a dry powder inhaler. In one example, lactose was used as the excipient and spray-dried with two different types of nanoparticle: gelatin and poly butylcyanoacrylate nanoparticles. The incorporation of nanoparticles did not affect the respirable fraction of the carrier powders.