Abstract: The invention concerns novel hydroxyalkanoic acid derivatives of the formula: ##STR1## in which A is a straight or branched chain (2-6C)alkylene, R.sup.1 and R.sup.2 are independently hydrogen or (1-6C) alkyl, and R.sup.3 is hydrogen or (1-6C)alkyl, and when R.sup.3 is hydrogen, base-addition salts thereof; and processes for their manufacture.The compounds possess useful anti-arthritic properties and the invention also concerns pharmaceutical compositions of such compounds for use in the treatment of arthritic joint diseases. A representative compound of the invention is 2-{2-[4-(4-chlorophenyl)phenyl]-ethoxy}propionic acid.

Abstract: Novel di-(substituted phenyl)methoxy acetic acids, alkyl homologues and related salts, ester and amides thereof, together with processes for their manufacture, and pharmaceutical compositions. A representative compound is di-(4-chlorophenyl)methyloxy acetic acid. The compounds possess anti-arthritic properties and in some cases, in addition, an effect on a factor involved in atherosclerotic disease.

Abstract: The invention concerns novel diarylmethyleneamino-oxyalkanoic acid derivatives which possess useful analgesic properties in warm-blooded animals. In addition certain of the derivatives also possess useful anti-inflammatory properties. Accordingly, the invention embraces oxyalkanoic acids, and simple esters and amides and non-toxic salts thereof, of the general formula: ##STR1## together with pharmaceutical compositions thereof, for use in the treatment of painful inflammatory joint diseases. In addition, the invention provides as a further feature various analogy processes for the manufacture of compounds of formula I.A representative compound of the invention is di-(4-chlorophenyl)methyleneamino-oxyacetic acid which has both analgesic and anti-inflammatory properties.