Abstract: Provided herein are implantable and bioresorbable sensors that are specifically designed to be implanted, function for an operational lifetime, and at some point after the operational lifetime to be resorbed by the body in such a manner so as to avoid having to remove any part of the sensor. This avoids a second impact on the patient otherwise associated with sensor removal. The sensors have a substrate and an electronic device supported by the substrate. A barrier layer isolates the electronic device from surrounding environment, including a biofluid, during use. Each of the substrate, electronic device, and barrier layer have a bioresorption rate during use to provide controlled bioresorption such reliable measure of one or more parameters occur over and an operational lifetime, and after a bioresorption lifetime greater than the operational lifetime, no detectable portion of the implantable and bioresorbable sensor remains at an implantation site.