Patents by Inventor Wim Albert Alex Aelterman

Wim Albert Alex Aelterman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
    Patent number: 8580981
    Abstract: The present invention relates to a process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate as well as novel intermediates for use in said process. (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate is particularly useful as an HIV protease inhibitor.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: November 12, 2013
    Assignee: Janssen R&D Ireland
    Inventors: Piet Tom Bert Paul Wigerinck, Dominique Louis Nestor Ghislain Surleraux, Wim Gaston Verschueren, Herman Augustinus De Kock, Wim Albert Alex Aelterman
  • Fumarate salt of (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
    Patent number: 8546428
    Abstract: The present invention relates to the fumarate salt of (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: October 1, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jean François Alexandre Lucas Hegyi, Wim Albert Alex Aelterman, Yolande Lydia Lang, Sigrid Carl Maria Stokbroekx, Carina Leys, Peter Jozef Maria Van Remoortere, Anne Faure
  • Methods for the preparation of hexahydrofuro[2,3-B]furan-3-ol
    Patent number: 8153829
    Abstract: Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol and especially its enantiomer (3R,3aS,6aR) hexahydrofuro[2,3-b]furan-3-ol, as well as certain novel intermediates for use in such methods are disclosed.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: April 10, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Sébastien François Emmanuel Lemaire, Andras Horvath, Wim Albert Alex Aelterman, Thomas Joachim Landewald Rammeloo
  • PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
    Publication number: 20110160468
    Abstract: The present invention relates to a process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate as well as novel intermediates for use in said process. (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate is particularly useful as an HIV protease inhibitor.
    Type: Application
    Filed: September 1, 2009
    Publication date: June 30, 2011
    Inventors: Piet Tom Bert Paul Wigerinck, Dominique Louis Nestor Ghislain Surleraux, Wim Gaston Verschueren, Herman Augustinus De Kock, Wim Albert Alex Aelterman
  • Preparation of 9-hydroxy-3-(2-hydroxyethyl)-2-methyl-4-pyrido[1,2-A]pyrimidin-4-one
    Patent number: 7723518
    Abstract: The present invention concerns a process for preparing crystalline 3-(2-chloro-ethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one substantially free of 2-acetylbutyrolactone.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: May 25, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Eduard Jozef Contantia Vreysen, Joannes Petrus Van Dun, Wim Albert Alex Aelterman
  • METHODS FOR THE PREPARATION OF HEXAHYDROFURO[2,3-b]FURAN-3-OL
    Publication number: 20100094028
    Abstract: Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol and especially its enantiomer (3R,3aS,6aR) hexahydrofuro[2,3-b]furan-3-ol, as well as certain novel intermediates for use in such methods.
    Type: Application
    Filed: November 9, 2007
    Publication date: April 15, 2010
    Applicant: TIBOTEC PHARMACEUTICALS LTD
    Inventors: Sébastien François Emmanuel Lemaire, Andras Horvath, Wim Albert Alex Aelterman, Thomas Joachim Landewald Rammeloo
  • FUMARATE SALT OF (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL
    Publication number: 20100028428
    Abstract: The present invention relates to the fumarate salt of (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1 -naphthalenyl-beta-phenyl-3-quinolineethanol, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.
    Type: Application
    Filed: December 3, 2007
    Publication date: February 4, 2010
    Inventors: Jean Francois Alexandre Lucas Hegyi, Wim Albert Alex Aelterman, Yolande Lydia Lang, Sigrid Carl Maria Stokbroekx, Carina Leys, Peter Josef Maria Van Remoortere, Anne Faure