Abstract: A system for detection and metrology of an allergen skin reaction of an individual, including: hosting a body part of the individual and subjecting a skin surface area of the body part to an allergen skin reaction test; with a plurality of light sources, successively illuminating the skin surface area having been subjected to the allergen skin reaction test under predetermined illumination angles; imaging, from a fixed position and for each of the predetermined illumination angles, the illuminated skin surface; and determining one or more illumination-angle-dependent variations in light intensity imaged by the acquisition means, wherein the illumination-angle-dependent variations are caused by one or more wheals on the skin surface area.