Patents by Inventor Wim van Schooten

Wim van Schooten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HEAVY CHAIN ANTIBODIES BINDING TO PSMA
    Publication number: 20220195068
    Abstract: Anti-PSMA heavy chain antibodies (e.g., UniAbs™) are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat disorders that are characterized by the expression of PSMA.
    Type: Application
    Filed: April 3, 2020
    Publication date: June 23, 2022
    Inventors: Wim van Schooten, Starlynn Clarke, Kevin Dang, Ben Buelow
  • MULTISPECIFIC HEAVY CHAIN ANTIBODIES WITH MODIFIED HEAVY CHAIN CONSTANT REGIONS
    Publication number: 20220089729
    Abstract: Multispecific, human heavy chain antibodies (e.g., UniAbs™) that have modified heavy chain constant regions that impart advantageous properties are provided. The invention further concerns methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat disorders that are characterized by expression of one or more of the binding targets described herein.
    Type: Application
    Filed: June 14, 2021
    Publication date: March 24, 2022
    Inventors: Katherine Harris, Ute Schellenberger, Omid Vafa, Nathan Trinklein, Wim van Schooten, Shelley Force Aldred, Duy Pham, Udaya Rangaswamy
  • CD3 BINDING ANTIBODIES
    Publication number: 20220025047
    Abstract: The present invention relates to novel human CD3 antigen-binding polypeptides and their preparation and use in the treatment and/or diagnosis of various diseases, and also relates to bispecific antibody molecules capable of activating immune effector cells and their use in diagnosis and/or treatment of various diseases.
    Type: Application
    Filed: October 1, 2021
    Publication date: January 27, 2022
    Inventors: Nathan Trinklein, Wim van Schooten, Shelley Force Aldred, Katherine Harris, Duy Pham
  • HEAVY CHAIN ANTIBODIES BINDING TO CD38
    Publication number: 20210388106
    Abstract: Binding compounds, such as human heavy-chain antibodies (e.g., UniAbs™) binding to CD38 are disclosed, along with methods of making such binding compounds, compositions, including pharmaceutical compositions, comprising such binding compounds, and their various uses.
    Type: Application
    Filed: October 28, 2019
    Publication date: December 16, 2021
    Inventors: Wim van Schooten, Starlynn Clarke, Kevin Dang
  • Multispecific heavy chain antibodies with modified heavy chain constant regions
    Patent number: 11186639
    Abstract: Multispecific, human heavy chain antibodies (e.g., UniAbs™) that have modified heavy chain constant regions that impart advantageous properties are provided. The invention further concerns methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat disorders that are characterized by expression of one or more of the binding targets described herein.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: November 30, 2021
    Assignee: TENEOONE, INC.
    Inventors: Katherine Harris, Ute Schellenberger, Omid Vafa, Nathan Trinklein, Wim van Schooten, Shelley Force Aldred, Duy Pham, Starlynn Clarke
  • MULTISPECIFIC HEAVY CHAIN ANTIBODIES WITH MODIFIED HEAVY CHAIN CONSTANT REGIONS
    Publication number: 20210340255
    Abstract: Multispecific, human heavy chain antibodies (e.g., UniAbs™) that have modified heavy chain constant regions that impart advantageous properties are provided. The invention further concerns methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat disorders that are characterized by expression of one or more of the binding targets described herein.
    Type: Application
    Filed: May 5, 2021
    Publication date: November 4, 2021
    Inventors: Katherine Harris, Ute Schellenberger, Omid Vafa, Nathan Trinklein, Wim van Schooten, Shelley Force Aldred, Duy Pham, Starlynn Clarke
  • HEAVY CHAIN ANTIBODIES BINDING TO CD19
    Publication number: 20210332133
    Abstract: Anti-CD19 heavy chain antibodies (e.g., UniAbs™) are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat B cell disorders that are characterized by the expression of CD19.
    Type: Application
    Filed: July 19, 2019
    Publication date: October 28, 2021
    Inventors: Shelley Force Aldred, Wim van Schooten, Katherine Harris, Udaya Rangaswamy, Nathan Trinklein
  • ANTI-BCMA HEAVY CHAIN-ONLY ANTIBODIES
    Publication number: 20210147564
    Abstract: Anti-BCMA heavy chain-only antibodies (UniAb) and disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat B-cell disorders characterized by the expression of BCMA.
    Type: Application
    Filed: June 20, 2018
    Publication date: May 20, 2021
    Inventors: Nathan Trinklein, Shelley Force Aldred, Katherine Harris, Wim van Schooten
  • CD3-DELTA/EPSILON HETERODIMER SPECIFIC ANTIBODIES
    Publication number: 20200339685
    Abstract: Novel human CD3 antigen-binding polypeptides and their preparation and use in the treatment and/or diagnosis of various diseases are provided, as well as bispecific antibody molecules capable of activating immune effector cells and their use in diagnosis and/or treatment of various diseases.
    Type: Application
    Filed: December 27, 2018
    Publication date: October 29, 2020
    Inventors: Ute Schellenberger, Nathan Trinklein, Wim van Schooten
  • HEAVY CHAIN ANTIBODIES BINDING TO ECTOENZYMES
    Publication number: 20200207867
    Abstract: Human heavy chain antibodies, such as UniAbs™, binding to ectoenzymes are provided along with combinations of such heavy chain antibodies and multi-specific heavy chain antibodies, targeting non-overlapping epitopes on ectoenzymes, including synergistic combinations. Methods of making such antibodies, compositions including pharmaceutical compositions comprising such antibodies, and methods directed to the treatment of disease or conditions associated with the expression of ectoenzymes are also included.
    Type: Application
    Filed: September 13, 2018
    Publication date: July 2, 2020
    Inventors: Starlynn Clarke, Kevin Dang, Shelley Force Aldred, Nathan Trinklein, Wim van Schooten
  • ANTI-BCMA HEAVY CHAIN-ONLY ANTIBODIES
    Publication number: 20200157232
    Abstract: Anti-BCMA heavy chain-only antibodies (UniAb) and disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat B-cell disorders characterized by the expression of BCMA.
    Type: Application
    Filed: June 20, 2018
    Publication date: May 21, 2020
    Inventors: Nathan Trinklein, Shelley Force Aldred, Starlynn Clarke, Wim van Schooten
  • ANTI-B-CELL MATURATION ANTIGEN CHIMERIC ANTIGEN RECEPTORS WITH HUMAN DOMAINS
    Publication number: 20200138865
    Abstract: Provided are chimeric antigen receptors (CARs) having antigen specificity for B-cell Maturation Antigen (BCMA). Also provided are related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs. Methods of treating or preventing cancer in a mammal are also provided.
    Type: Application
    Filed: June 28, 2018
    Publication date: May 7, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, TeneoBio, Inc.
    Inventors: James N. Kochenderfer, Norris Lam, Nathan Trinklein, Katherine E. Harris, Shelley Force Aldred, Wim Van Schooten
  • CD3 BINDING ANTIBODIES
    Publication number: 20200048348
    Abstract: The present invention relates to novel human CD3 antigen-binding polypeptides and their preparation and use in the treatment and/or diagnosis of various diseases, and also relates to bispecific antibody molecules capable of activating immune effector cells and their use in diagnosis and/or treatment of various diseases.
    Type: Application
    Filed: June 20, 2017
    Publication date: February 13, 2020
    Inventors: Nathan Trinklein, Wim van Schooten, Shelley Force Aldred, Katherine Harris, Duy Pham
  • ANTI-BCMA HEAVY CHAIN-ONLY ANTIBODIES
    Publication number: 20190352412
    Abstract: Anti-BCMA heavy chain-only antibodies (HCAb) and disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat B-cell disorders characterized by the expression of BCMA.
    Type: Application
    Filed: December 21, 2017
    Publication date: November 21, 2019
    Inventors: Shelley Force Aldred, Nathan Trinklein, Katherine E. Harris, Kevin Dang, Wim van Schooten
  • CD3 BINDING ANTIBODIES
    Publication number: 20190263904
    Abstract: The present invention relates to novel human CD3 antigen-binding polypeptides and their preparation and use in the treatment and/or diagnosis of various diseases, and also relates to bispecific antibody molecules capable of activating immune effector cells and their use in diagnosis and/or treatment of various diseases.
    Type: Application
    Filed: June 20, 2017
    Publication date: August 29, 2019
    Inventors: Nathan Trinklein, Wim van Schooten, Shelley Force Aldred, Katherine Harris, Duy Pham
  • TRANSGENIC NON-HUMAN ANIMALS PRODUCING MODIFIED HEAVY CHAIN-ONLY ANTIBODIES
    Publication number: 20190225671
    Abstract: Human or chimeric heavy chain-only antibodies are provided, in the native amino acid residue at the first position of the fourth framework region (FR4) of said HCAb is substituted by a different amino acid residue that is capable of disrupting a surface-exposed hydrophobic patch comprising or associated with the native amino acid residue at that position.
    Type: Application
    Filed: August 22, 2017
    Publication date: July 25, 2019
    Inventors: Wim van Schooten, Nathan Trinklein, Shelley Force-Aldred, Marianne Bruggemann, Mike Osborn
  • BISPECIFIC THREE-CHAIN ANTIBODY-LIKE MOLECULES
    Publication number: 20140056897
    Abstract: The present invention relates to novel bispecific three-chain antigen-binding polypeptides and their preparation and use in the treatment and/or diagnosis of various diseases, and also relates to bispecific three-chain antibody-like molecules (TCAs) capable of activating immune effector cells and their use in diagnosis and/or treatment of various diseases.
    Type: Application
    Filed: March 9, 2012
    Publication date: February 27, 2014
    Applicant: HCO Antibody, Inc.
    Inventors: Roland Buelow, Wim van Schooten
  • Humanized immunoglobulin loci
    Patent number: 8652842
    Abstract: The present invention concerns methods and means to produce humanized antibodies from transgenic non-human animals. The invention specifically relates to novel immunoglobulin heavy and light chain constructs, recombination and transgenic vectors useful in making transgenic non-human animals expressing humanized antibodies, transgenic animals, and humanized immunoglobulin preparations.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: February 18, 2014
    Assignee: Therapeutic Human Polyclonals, Inc
    Inventors: Josef Platzer, Roland Buelow, Wim van Schooten
  • Humanized immunoglobulin loci
    Patent number: 8410333
    Abstract: The present invention concerns methods and means to produce humanized antibodies from transgenic non-human animals. The invention specifically relates to novel immunoglobulin heavy and light chain constructs, recombination and transgenic vectors useful in making transgenic non-human animals expressing humanized antibodies, transgenic animals, and humanized immunoglobulin preparations.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: April 2, 2013
    Assignee: Therapeutic Human Polyclonals, Inc.
    Inventors: Roland Buelow, Wim van Schooten, Josef Platzer
  • Humanized immunoglobulin loci
    Patent number: RE47131
    Abstract: The present invention concerns methods and means to produce humanized antibodies from transgenic non-human animals. The invention specifically relates to novel immunoglobulin heavy and light chain constructs, recombination and transgenic vectors useful in making transgenic non-human animals expressing humanized antibodies, transgenic animals, and humanized immunoglobulin preparations.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: November 20, 2018
    Assignee: Therapeutic Human Polyclonals, Inc.
    Inventors: Josef Platzer, Roland Buelow, Wim van Schooten