Abstract: A diagnostic kit as well as a method for the examination of a human patient sample for the presence of neuromyelitis optica-specific antibodies are described, for which an initial substrate is incubated with human sample material, and said incubated initial substrate is examined using indirect immunofluorescence, whether neuromyelitis optica-specific antibodies have at least partially bound to said initial substrate. The solution described is characterized in that as said initial substrate, an aquaporin-4-containing native substrate is used as well as that said neuromyelitis optica-specific antibodies at least partially bound to said aquaporin-4-containing initial substrate are reacted with components of the complement system and the reaction of said complement system is detected by way of an indicator reaction.

Abstract: The present invention concerns goblet cell antigen, a method for detecting antibodies directed against goblet cell antigen, a method based thereon for diagnosis of inflammatory bowel diseases and a kit for diagnosis of inflammatory bowel diseases, as well as monoclonal antibodies directed against goblet cell antigen.

Abstract: The present invention relates to a method for producing a nucleosome preparation that is characterised by being suitable for use in immunofluorescence assays of specific antibodies directed against the nucleosomes in human samples and thus for a more specific diagnosis of disseminated lupus erythematosus (LED) compared with the state of the art.

Abstract: Processes for testing immobilized biological material with generally biochemical and histochemical methods, particularly enzyme, immuno and hormone chemical methods can be improved by adhering the biological material to the surface of a support and then fixing the support to a plate. The plate is constructed in such a way that the biological material is protected from damage. Using a biological testing technique such as thin section immunofluorescence testing the invention makes it possible to carry out biochemical tests in a more rational and trouble-free manner than with hitherto known methods. If necessary, a random number of tests can be performed side-by-side on a single plate. The invention makes it possible to simply and rapidly prepare frozen section products and store them in a space-saving manner at very low temperatures. The adhesion of the frozen sections to the support can be improved by coupling chemicals which react with the tissue by bonding thereto to the support.