Abstract: An apparatus is proposed for identifying respective cover slip regions of respective cover slips having respective tissue sections on a specimen slide, which has multiple optical identifiers. The apparatus includes a planar light source, an image acquisition unit, a holding unit for positioning the specimen slide between the planar light source and the image acquisition unit, a slit diaphragm, which has multiple opening slits, reversibly positionable between the planar light source and the specimen slide, and an illumination unit, which is designed to illuminate that surface of the specimen slide which faces toward the image acquisition unit. Furthermore, the apparatus includes a monitoring unit which is designed, on the basis of a completely illuminated transmitted light image, an incident light image, and a partially darkened transmitted light image, to assign respective tissue sections to respective optical identifiers.

Abstract: A method includes detecting in a sample a mammalian antibody binding specifically to ZSCAN5. A mammalian antibody binds specifically to ZSCAN5, and a carrier with a solid phase with at least one immobilized polypeptide includes at least one epitope of ZSCAN5 or a variant thereof. The mammalian antibody is used for diagnosing a neurological autoimmune disease or a cancer.

Abstract: A pressure-tight storage vessel contains a liquid, has an elongated main body rotationally symmetrical with respect to an axis of symmetry, and forms, at least partially, a rotationally symmetrical hollow space in which the liquid is substantially received, wherein the main body is terminated at its bottom side by a base. Furthermore, at its top side, the storage vessel has an opening which is closed off in a pressure-tight manner by a closure, has a plurality of reinforcement elements, which bears against the main body at the outside, which extends parallel to the axis of symmetry of the main body, and arranged rotationally symmetrically about the axis of symmetry of the main body. In each case between adjacent reinforcement elements, respective externally exposed wall sections of the main body are formed, and the composition of the exposed wall sections permits a pressure-tight insertion by at least two hollow needles.

Abstract: An apparatus is proposed for identifying respective cover slip regions of respective cover slips having respective tissue sections on a specimen slide, which has multiple optical identifiers. The apparatus includes a planar light source, an image acquisition unit, a holding unit for positioning the specimen slide between the planar light source and the image acquisition unit, a slit diaphragm, which has multiple opening slits, reversibly positionable between the planar light source and the specimen slide, and an illumination unit, which is designed to illuminate that surface of the specimen slide which faces toward the image acquisition unit. Furthermore, the apparatus includes a monitoring unit which is designed, on the basis of a completely illuminated transmitted light image, an incident light image, and a partially darkened transmitted light image, to assign respective tissue sections to respective optical identifiers.

Abstract: An incubation device has multiple rocking platforms with each platform pivotally mounted about a respective axis. Each rocking platform has a respective receiving device for mechanically reversibly receiving a respective incubation channel. The device also has a common drive unit for common respective rocking movements of each platform from a zero position through with a specific angle range as a result of movement of the drive unit. Each rocking platform is coupled to the drive unit via a respective coupling mechanism, and each coupling mechanism elastically and resiliently couples the respective rocking platform to the drive unit, such that when the rocking platform is restrained, despite continuation of the drive movement, the rocking platform remains motionless in a fixed position. After release of the restraint on the rocking platform, the rocking platform resumes the rocking movement with the specific angle range.

Abstract: The present invention relates to a method for diagnosing a disease comprising the step detecting in a sample comprising antibodies from a patient an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a polypeptide comprising a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, or a variant thereof, a use of said polypeptide for the diagnosis of a disease, an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a use of the autoantibody for the diagnosis of a disease, a method for isolating an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a pharmaceutical composition or medical device comprising said polypeptide according to the present invention, a kit for the diagnosis of a disease comprising said polypeptide or said medical device and a use of said polypeptide or autoantibody for the manufacture of a kit or medical device.

Abstract: A method is useful for automated detection of antibodies in a liquid biological sample with an antigen chip having antigen spots which are applied thereon and which have an identical, common dye. The antigen spots form respective antigen spot sets which form corresponding respective, regular antigen spot patterns. Furthermore, reference spots comprising the identical dye are applied, and form a reference spot set which forms a regular reference pattern. The reference pattern differs with respect to its regularity from the antigen spot patterns. Through a first image information item which represents a color of the reference spots and of the antigen spots due to the identical, first dye and through a second image information item which represents a potential color of the antigen spots due to a second dye after an incubation, binding of antibodies of the biological sample to respective antigen types is then determined by image processing.

Abstract: A polypeptide contains laminin beta-4 and a carrier contains the polypeptide. An antibody, preferably autoantibody, is against laminin beta-4. Furthermore, use of the polypeptide, carrier or autoantibody for the diagnosis of a disease, and a method with the step of detecting an autoantibody against laminin beta-4 in a sample are described.

Abstract: A method is useful for automated detection of antibodies in a liquid biological sample with an antigen chip having antigen spots which are applied thereon and which have an identical, common dye. The antigen spots form respective antigen spot sets which form corresponding respective, regular antigen spot patterns. Furthermore, reference spots comprising the identical dye are applied, and form a reference spot set which forms a regular reference pattern. The reference pattern differs with respect to its regularity from the antigen spot patterns. Through a first image information item which represents a color of the reference spots and of the antigen spots due to the identical, first dye and through a second image information item which represents a potential color of the antigen spots due to a second dye after an incubation, binding of antibodies of the biological sample to respective antigen types is then determined by image processing.

Abstract: A sample support has an absorbent membrane layer which is based on a nonwoven polyolefin and which has at least one take-up region with dried blood constituents. It moreover has a film layer based on a plastic, where the film layer has received antistatic pretreatment. The membrane layer and the film layer have been connected to one another mechanically in one subregion of the sample support. but the layers have moreover not been connected to one another mechanically in the take-up region. It is preferable that, when the sample support is placed onto a uniformly level surface the membrane layer covers the film layer at least in the take-up region.

Abstract: A carrier includes at least one take-up region based on a non-woven polyolefin containing dried-up capillary blood. The carrier is useful for semi-quantitatively, preferably quantitatively determining the concentration of an analyte in a blood sample. Further, a method is used for detecting an analyte in a blood sample and includes the steps of providing the carrier, applying a blood sample to the take-up region of the carrier, drying the carrier, contacting the carrier containing the dried-up capillary blood with a liquid which is suitable for taking up the analyte from the dried-up blood sample, and detecting the analyte in the liquid.

Abstract: The present invention relates to a method for diagnosing a disease comprising the step detecting in a sample comprising antibodies from a patient an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a polypeptide comprising a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, or a variant thereof, a use of said polypeptide for the diagnosis of a disease, an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a use of the autoantibody for the diagnosis of a disease, a method for isolating an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a pharmaceutical composition or medical device comprising said polypeptide according to the present invention, a kit for the diagnosis of a disease comprising said polypeptide or said medical device and a use of said polypeptide or autoantibody for the manufacture of a kit or medical device.

Abstract: The present invention relates to a method for diagnosing a disease comprising the step detecting in a sample comprising antibodies from a patient an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a polypeptide comprising a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, or a variant thereof, a use of said polypeptide for the diagnosis of a disease, an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a use of the autoantibody for the diagnosis of a disease, a method for isolating an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a pharmaceutical composition or medical device comprising said polypeptide according to the present invention, a kit for the diagnosis of a disease comprising said polypeptide or said medical device and a use of said polypeptide or autoantibody for the manufacture of a kit or medical device.

Abstract: A pressure-tight storage vessel contains a liquid, has an elongated main body rotationally symmetrical with respect to an axis of symmetry, and forms, at least partially, a rotationally symmetrical hollow space in which the liquid is substantially received, wherein the main body is terminated at its bottom side by a base. Furthermore, at its top side, the storage vessel has an opening which is closed off in a pressure-tight manner by a closure, has a plurality of reinforcement elements, which bears against the main body at the outside, which extends parallel to the axis of symmetry of the main body, and arranged rotationally symmetrically about the axis of symmetry of the main body. In each case between adjacent reinforcement elements, respective externally exposed wall sections of the main body are formed, and the composition of the exposed wall sections permits a pressure-tight insertion by at least two hollow needles.

Abstract: A polypeptide contains laminin beta-4 and a carrier contains the polypeptide. An antibody, preferably autoantibody, is against laminin beta-4. Furthermore, use of the polypeptide, carrier or autoantibody for the diagnosis of a disease, and a method with the step of detecting an autoantibody against laminin beta-4 in a sample are described.

Abstract: A device for incubating an immunoblot strip (6) includes at least one incubation channel (1) into which an elongate immunoblot strip (6) having at least one biological material on its front is inserted with its back facing a channel base (2). An agitating means (7), with which the immunoblot strip (6) is agitatable around a transverse axis (8) of the strip (6) at least at times during incubation via an agitating device (7). For handling and/or grouping incubation channels (1) with immunoblot strips (6) inserted, a rack (3) for taking up at least two incubation channels (1) is provided. The rack (3) is in operative connection with said agitating means (7) via load transmission points.

Abstract: A cover (1), and a building wall (2) with the cover (1), has at least two plate-shaped structural components (3a, 3b) with top (front) and rear sides (4, 5) arranged at least largely in parallel to the building wall (2). The plate-shaped structural components (3a, 3b) are fastened at spaced locations to the building wall (2) by one or more support element (8). Narrow side (end) surfaces (6) of the plate-shaped structural components (3a, 3b) are arranged obliquely between the front and rear sides (4, 5) of the plate-shaped structural components (3a, 3b). The two plate-shaped structural components (3a, 3b) are arranged in relation to one another such that the oblique narrow side surfaces (6) of the plate-shaped structural components (3a, 3b) are arranged plane-parallel and overlap each other in an overlapping area (9) in at least some sections.

Abstract: An antigen chip is described, the latter comprising a plane substrate surface; and antigen spots, which are applied in a predetermined pattern on the substrate surface and which contain a first fluorescence dye. Further, an apparatus and a method for detecting antibodies in a sample are provided. Even further, the application relates to kit for use in a method for detecting antibodies in a sample.

Abstract: A method is for producing biological material-coated solid-phase fragments. The method first provides a biological material-coated solid-phase support in a fragmented state and the biological material-coated solid-phase fragment adhered to a film. Then, a tensile stress is generated on the film, which is then contacted with a lifting head to pre-detach the biological material-coated solid-phase fragment from the film. The fragment is then taken off from the film. A device for producing the biological material-coated solid-phase fragment includes a tensile-stress unit, a lifting-head unit and a removal unit.