Patents by Inventor Wing H. Wong
Wing H. Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10438686Abstract: Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.Type: GrantFiled: August 19, 2016Date of Patent: October 8, 2019Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mylene W. M. Yao, Wing H. Wong
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Publication number: 20190042696Abstract: Methods, software, and systems for aligning a read sequence to a reference sequence are disclosed. In certain embodiments, the methods, software, and systems involve determining similarity of distribution of k-mers between a region of the read sequence and a region of the reference sequence in order to determine whether the region of the read sequence maps to the region of the reference sequence.Type: ApplicationFiled: February 10, 2017Publication date: February 7, 2019Inventors: Wing H. WONG, Pegah Tootoonchi AFSHAR
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Patent number: 9934361Abstract: Provided is a method for generating prediction models from multiple healthcare centers. The method allows a third party to use data sets from multiple sources to build prediction models. By entering the data sets in a Model Deconstruction and Transfer (MDT) platform, a healthcare center may provide data to a third party without the need to de-identify data or to physically transfer any identifying or de-identified data from the healthcare center. The MDT platform includes a variable library, which allows the healthcare center to select variables that will be used to generate and validate the prediction model. Also provided is a method for compensating sources that contribute data sets based upon the percentage of clinical data that is used to generate a prediction model.Type: GrantFiled: September 29, 2012Date of Patent: April 3, 2018Assignee: UNIVFY Inc.Inventors: Mylene Yao, Wing H. Wong, Bokyung Choi
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Patent number: 9928338Abstract: The present disclosure presents a unified system to phase a personal genome for downstream clinical interpretation. In an embodiment, an initial phasing is generated using public datasets, such as haplotypes from the 1000 Genomes Project, and a phasing toolkit. A local perturbation algorithm is applied to improve long range phasing. If available, a Mendelian inheritance pipeline is applied to identify phasing of novel and rare variants. These datasets are merged, followed by correction by any experimental data. This allows for full clinical interpretation of the role of a group of variants in a gene, whether inherited or de novo variants.Type: GrantFiled: June 1, 2012Date of Patent: March 27, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Hua Tang, Michael Snyder, Jennifer Li-Pook Than, Konrad J. Karczewski, Nicholas Johnson, Wing H. Wong
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Publication number: 20160357917Abstract: Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.Type: ApplicationFiled: August 19, 2016Publication date: December 8, 2016Inventors: Mylene W.M. Yao, Wing H. Wong
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Patent number: 9458495Abstract: Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.Type: GrantFiled: July 1, 2009Date of Patent: October 4, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mylene W. M. Yao, Wing H. Wong
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Patent number: 9303289Abstract: The present disclosure provides methods for determining phased nucleic acid sequence for a single chromosome of interest and/or a single chromosomal fragment of interest. The present disclosure also provides methods for determining phased nucleic acid sequence for a plurality of single chromosomes of interest and/or a plurality of single chromosomal fragments of interest. The plurality of single chromosomes of interest may be of one chromosome type or of two or more chromosome types. The present disclosure also provides a method for isolating a plurality of chromosomal fragments of a specified size range, where the chromosomal fragments are from one or more specified regions of the genome. The plurality of chromosomal fragments may be separated into single chromosomal fragments and sequenced to provide phased nucleic acid sequence for the single chromosomal fragments.Type: GrantFiled: July 14, 2014Date of Patent: April 5, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Wing H. Wong, Hong Yang
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Publication number: 20160090624Abstract: The present disclosure provides methods for determining phased nucleic acid sequence for a single chromosome of interest and/or a single chromosomal fragment of interest. The present disclosure also provides methods for determining phased nucleic acid sequence for a plurality of single chromosomes of interest and/or a plurality of single chromosomal fragments of interest. The plurality of single chromosomes of interest may be of one chromosome type or of two or more chromosome types. The present disclosure also provides a method for isolating a plurality of chromosomal fragments of a specified size range, where the chromosomal fragments are from one or more specified regions of the genome. The plurality of chromosomal fragments may be separated into single chromosomal fragments and sequenced to provide phased nucleic acid sequence for the single chromosomal fragments.Type: ApplicationFiled: December 1, 2015Publication date: March 31, 2016Inventors: Wing H. Wong, Hong Yang
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Publication number: 20150011409Abstract: The present disclosure provides methods for determining phased nucleic acid sequence for a single chromosome of interest and/or a single chromosomal fragment of interest. The present disclosure also provides methods for determining phased nucleic acid sequence for a plurality of single chromosomes of interest and/or a plurality of single chromosomal fragments of interest. The plurality of single chromosomes of interest may be of one chromosome type or of two or more chromosome types. The present disclosure also provides a method for isolating a plurality of chromosomal fragments of a specified size range, where the chromosomal fragments are from one or more specified regions of the genome. The plurality of chromosomal fragments may be separated into single chromosomal fragments and sequenced to provide phased nucleic acid sequence for the single chromosomal fragments.Type: ApplicationFiled: July 14, 2014Publication date: January 8, 2015Inventors: Wing H. Wong, Hong Yang
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Patent number: 8778638Abstract: The present disclosure provides methods for determining phased nucleic acid sequence for a single chromosome of interest and/or a single chromosomal fragment of interest. The present disclosure also provides methods for determining phased nucleic acid sequence for a plurality of single chromosomes of interest and/or a plurality of single chromosomal fragments of interest. The plurality of single chromosomes of interest may be of one or more chromosome types. The present disclosure also provides a method for isolating a plurality of chromosomal fragments of a specified size range, where the chromosomal fragments are from one or more specified regions of the genome. The plurality of chromosomal fragments may be separated into single chromosomal fragments and sequenced to provide phased nucleic acid sequence for the single chromosomal fragments. Alternatively, the plurality of chromosomal fragments may be sequenced together to provide unphased nucleic acid sequence for the chromosomal fragments.Type: GrantFiled: November 15, 2011Date of Patent: July 15, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Wing H. Wong, Hong Yang
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Publication number: 20130297221Abstract: In an embodiment of the present invention, a modified version of the PHASE model is implemented that is substantially more accurate than the FastPHASE model. Modifications in an embodiment of the present invention include using a parameterization EM algorithm similar to that of the FastPHASE model, and to perform optimization on haplotypes rather than MCMC sampling. In an embodiment, the imputed haplotypes themselves are used as hidden states in the HMM because this is believed to be important for the PHASE model's accuracy. This increase in accuracy becomes more pronounced with increasing sample size. This difference is attributed to the PHASE model's likelihood which produces long, shared haplotypes between pairs of individuals.Type: ApplicationFiled: June 1, 2012Publication date: November 7, 2013Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Nicholas Johnson, Wing H. Wong, Hua Tang
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Publication number: 20130085728Abstract: The present disclosure presents a unified system to phase a personal genome for downstream clinical interpretation. In an embodiment, an initial phasing is generated using public datasets, such as haplotypes from the 1000 Genomes Project, and a phasing toolkit. A local perturbation algorithm is applied to improve long range phasing. If available, a Mendelian inheritance pipeline is applied to identify phasing of novel and rare variants. These datasets are merged, followed by correction by any experimental data. This allows for full clinical interpretation of the role of a group of variants in a gene, whether inherited or de novo variants.Type: ApplicationFiled: June 1, 2012Publication date: April 4, 2013Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Hua Tang, Michael Snyder, Jennifer Li-Pook-Than, Konrad J. Karczewski, Nicholas Johnson, Wing H. Wong
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Patent number: 8341097Abstract: Circuits, devices and methods for processing learning networks are implemented using a variety of methods and devices. One example involves a circuit-implemented method to identify a relationship of objects in a set of objects. Local scores are generated for the object and possible parents. The local scores indicate relationship strength between object and parent. The results are stored in a memory. A state-machine circuit is used to perform sampling and searching of the parent sets for each data node. The local scores are used to encode orderings of the parent. An algorithm is executed that uses the encoded possible orderings and a random variable to generate and score a current order and a proposed order of the possible parent sets. The proposed orders are accepted or rejected based on probability rules applied to the scores for the current and proposed orders. Structures are sampled to assess a Bayesian-based relationship.Type: GrantFiled: January 29, 2010Date of Patent: December 25, 2012Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Teresa H. Meng, Wing H. Wong, Narges Asadi Bani
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Publication number: 20120149588Abstract: The present disclosure provides methods for determining phased nucleic acid sequence for a single chromosome of interest and/or a single chromosomal fragment of interest. The present disclosure also provides methods for determining phased nucleic acid sequence for a plurality of single chromosomes of interest and/or a plurality of single chromosomal fragments of interest. The plurality of single chromosomes of interest may be of one or more chromosome types. The present disclosure also provides a method for isolating a plurality of chromosomal fragments of a specified size range, where the chromosomal fragments are from one or more specified regions of the genome. The plurality of chromosomal fragments may be separated into single chromosomal fragments and sequenced to provide phased nucleic acid sequence for the single chromosomal fragments. Alternatively, the plurality of chromosomal fragments may be sequenced together to provide unphased nucleic acid sequence for the chromosomal fragments.Type: ApplicationFiled: November 15, 2011Publication date: June 14, 2012Inventors: Wing H. Wong, Hong Yang
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Publication number: 20120078821Abstract: The present disclosure describes an extension of the Pólya Tree approach for constructing distributions on the space of probability measures. By using optional stopping and optional choice of splitting variables, the present invention gives rise to random measures that are absolutely continuous with piecewise smooth densities on partitions that can adapt to fit the data. The resulting optional Pólya tree distribution has large support in total variation topology, and yields posterior distributions that are also optional Pólya trees with computable parameter values.Type: ApplicationFiled: September 25, 2010Publication date: March 29, 2012Applicant: The Board of Trustees of the Leland Srandford Junior UniversityInventors: Li Ma, Wing H. Wong
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Publication number: 20100198761Abstract: Circuits, devices and methods for processing learning networks are implemented using a variety of methods and devices. One example involves a circuit-implemented method to identify a relationship of objects in a set of objects. Local scores are generated for the object and possible parents. The local scores indicate relationship strength between object and parent. The results are stored in a memory. A state-machine circuit is used to perform sampling and searching of the parent sets for each data node. The local scores are used to encode orderings of the parent. An algorithm is executed that uses the encoded possible orderings and a random variable to generate and score a current order and a proposed order of the possible parent sets. The proposed orders are accepted or rejected based on probability rules applied to the scores for the current and proposed orders. Structures are sampled to assess a Bayesian-based relationship.Type: ApplicationFiled: January 29, 2010Publication date: August 5, 2010Inventors: Teresa H. Meng, Wing H. Wong, Narges Bani Asadi
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Publication number: 20100036192Abstract: Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.Type: ApplicationFiled: July 1, 2009Publication date: February 11, 2010Inventors: Mylene W.M. Yao, Wing H. Wong
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Patent number: 7083929Abstract: The invention is directed to a method for sequencing multiple target polynucleotide segments in parallel, and to compositions and kits therefor. In the method, a plurality of sample polynucleotide fragments are used to form a mixture of different-length sequencing fragments. The sequencing fragments are complementary to at least two different sample fragments, wherein (1) each sequencing fragment terminates at a predefined end with a known base or bases, and (2) each sequencing fragment contains an identifier tag sequence that identifies the sample fragment to which the sequencing fragment corresponds. The sequencing fragments are then separated on the basis of size to produce a plurality of resolved, size-separated bands. Resolved bands are collected in separate aliquots, which, in a preferred embodiment, are then subjected to an amplification step to amplify the complements of the tag sequences in each aliquot, and preferably, the tag sequences too. Amplification is preferably by PCR.Type: GrantFiled: July 25, 2003Date of Patent: August 1, 2006Assignee: The Chinese University of Hong KongInventor: Wing H. Wong
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Publication number: 20040029165Abstract: The invention is directed to a method for sequencing multiple target polynucleotide segments in parallel, and to compositions and kits therefor. In the method, a plurality of sample polynucleotide fragments are used to form a mixture of different-length sequencing fragments. The sequencing fragments are complementary to at least two different sample fragments, wherein (1) each sequencing fragment terminates at a predefined end with a known base or bases, and (2) each sequencing fragment contains an identifier tag sequence that identifies the sample fragment to which the sequencing fragment corresponds. The sequencing fragments are then separated on the basis of size to produce a plurality of resolved, size-separated bands. Resolved bands are collected in separate aliquots, which, in a preferred embodiment, are then subjected to an amplification step to amplify the complements of the tag sequences in each aliquot, and preferably, the tag sequences too. Amplification is preferably by PCR.Type: ApplicationFiled: July 25, 2003Publication date: February 12, 2004Applicant: The Chinese University of Hong KongInventor: Wing H. Wong
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Publication number: 20020098479Abstract: The invention is directed to a method for sequencing multiple target polynucleotide segments in parallel, and to compositions and kits therefor. In the method, a plurality of sample polynucleotide fragments are used to form a mixture of different-length sequencing fragments. The sequencing fragments are complementary to at least two different sample fragments, wherein (1) each sequencing fragment terminates at a predefined end with a known base or bases, and (2) each sequencing fragment contains an identifier tag sequence that identifies the sample fragment to which the sequencing fragment corresponds. The sequencing fragments are then separated on the basis of size to produce a plurality of resolved, size-separated bands. Resolved bands are collected in separate aliquots, which, in a preferred embodiment, are then subjected to an amplification step to amplify the complements of the tag sequences in each aliquot, and preferably, the tag sequences too. Amplification is preferably by PCR.Type: ApplicationFiled: August 10, 1999Publication date: July 25, 2002Inventor: WING H. WONG