Patents by Inventor Wing Keung CHAN

Wing Keung CHAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bivalent antibody directed against NKG2D and tumor associated antigens
    Patent number: 10973914
    Abstract: A polypeptide is disclosed that binds tumor-associated antigens (TAA) on the surface of cancer cells and a NKG2D receptor. The NKG2D receptor is expressed on the surfaces of killer cells such as natural killer cells, T cells, natural killer T cells, and gamma delta T cells. In some cases, the TAA is CS-1 or EGFRvIII. Also disclosed are polynucleotides encoding the disclosed polypeptides, vectors comprising the disclosed polynucleotides, and host cells comprising the disclosed vectors. Also disclosed are bivalent antibodies comprising the disclosed polypeptides. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies. Also disclosed are methods of treating cancer in a subject using the disclosed bi-specific antibodies.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: April 13, 2021
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Jianhua Yu, Michael Caligiuri, Wing Keung Chan
  • BIVALENT ANTIBODY DIRECTED AGAINST NKG2D AND TUMOR ASSOCIATED ANTIGENS
    Publication number: 20180237519
    Abstract: A polypeptide is disclosed that binds tumor-associated antigens (TAA) on the surface of cancer cells and a NKG2D receptor. The NKG2D receptor is expressed on the surfaces of killer cells such as natural killer cells, T cells, natural killer T cells, and gamma delta T cells. In some cases, the TAA is CS-1 or EGFRvIII. Also disclosed are polynucleotides encoding the disclosed polypeptides, vectors comprising the disclosed polynucleotides, and host cells comprising the disclosed vectors. Also disclosed are bivalent antibodies comprising the disclosed polypeptides. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies. Also disclosed are methods of treating cancer in a subject using the disclosed bi-specific antibodies.
    Type: Application
    Filed: February 22, 2016
    Publication date: August 23, 2018
    Inventors: Michael CALIGIURI, Wing Keung CHAN, Jianhua YU