Patents by Inventor Winston T. K. Cheng

Winston T. K. Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Newly identified human small intestine extracellular lactase-phlorizin hydrolase (ecLPH) gene
    Patent number: 7795234
    Abstract: The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-phlorizin hydrolase (ecLPH) gene that can express human lactase-hydrolyzing enzyme in the mammary gland of animals. The invention can be used in the production of low-lactose milk.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: September 14, 2010
    Assignee: National Chung Hsing University
    Inventors: Chuan-Mu Chen, Winston T. K. Cheng, Hsiao-Ling Chen
  • Transgenic mammal secreting B-domain deleted human FVII in its milk
    Patent number: 7667089
    Abstract: Hemophilia A is one of the major inherited bleeding disorders caused by a deficiency or abnormality in coagulation factor VIII (FVIII). Hemophiliacs have been treated with whole plasma or purified FVIII concentrates. The risk of transmitting blood-borne viruses and the cost of highly purified FVIII are the major factors that restrict prophylaxis in hemophilia therapy. One of the challenges created by the biotechnology revolution is the development of methods for the economical production of highly purified proteins in large scales. The present invention provides improved mammary expression cassettes useful for the expression of genes at high levels in the milk of transgenic animals. In particular, the present invention provides recombinant signal peptide sequences derived from a-lactalbumin and aS1-casein milk genes suitable for leading protein secretion in the mammary gland.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: February 23, 2010
    Assignee: National Chung Hsing University
    Inventors: Winston T. K. Cheng, Chuan-Mu Chen, Shwu-Wha Lin, Chih-Hong Wang, Chih-Jen Lin, Shinn-Chih Wu
  • Transgenic animals producing low-lactose milk and newly identified human small intestinal extracellular lactase-phlorizin hydrolase (ecLPH) gene
    Patent number: 7501554
    Abstract: The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-phlorizin hydrolase (ecLPH) gene that can express human lactase-hydrolyzing enzyme in the mammary gland of animals. The invention can be used in the production of low-lactose milk.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: March 10, 2009
    Assignee: National Chung Hsing University
    Inventors: Chuan-Mu Chen, Winston T. K. Cheng, Hsiao-Ling Chen
  • Allergen-containing milk for allergy treatment
    Publication number: 20020197268
    Abstract: A milk composition that includes a heterologous non-milk allergen is administered to a subject to suppress allergen-specific IgE production in the subject
    Type: Application
    Filed: June 8, 2001
    Publication date: December 26, 2002
    Inventors: Hsu Ching-Hsaing, Winston T.K. Cheng