Abstract: In one aspect, embodiments disclosed herein are directed to engineered CRISPRCas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type. In certain example embodiments, the CRISPR-Cas effector protein is a Type II effector protein. In certain other example embodiments, the Type V effector protein is Cas9 or an orthologs or engineered variant thereof. Example Cas9 proteins suitable for use in the embodiments disclosed herein are discussed in further detail below.

Abstract: A dental plaque cleanser is a dental clinic device for cleansing dental supragingival and subgingival plaque biofilm as well as scaling calculus. The dental plaque cleanser comprises a water jet biofilm cleansing unit and an ultrasonic scaling unit.

Abstract: A compact oral hygiene device includes a unique mini constant jet pump which integrated with a motor, has three diaphragm chambers, draws the fluid from a reservoir and propels fluid out from a buffer room to tips at constant pulseless, high efficiencies and low noise; and a plurality of exchangeable tips cleanses teeth and the interdental area.

Abstract: A 7-way dental syringe is a device in a dental delivery system that delivers an air stream, water stream, air spray and water spray; four efficient ways to clean a patient's mouth. Additionally, the 7-way dental syringe is a controllable pressurized dental water jet system. It can dislodge plaque biofilms from teeth and interdental regions, access a periodontal pocket to wash out plaque therein, and cleanse a tooth extraction site or irrigate exposed jawbone; various clinical ways to perform advanced oral hygiene.

Abstract: A 7-way dental syringe is a device in a dental delivery system that delivers an air stream, water stream, air spray and water spray; four efficient ways to clean a patient's mouth. Additionally, the 7-way dental syringe is a controllable pressurized dental water jet system. It can dislodge plaque biofilms from teeth and interdental regions, access a periodontal pocket to wash out plaque therein, and cleanse a tooth extraction site or irrigate exposed jawbone; various clinical ways to perform advanced oral hygiene.

Abstract: A compact oral hygiene device comprises a unique mini constant jet pump which integrated with a motor, has three diaphragm chambers, draws the fluid from a reservoir and propels fluid out from a buffer room to tips at constant pulseless, high efficiencies and low noise; and a plurality of exchangeable tips cleanses teeth and the interdental area.

Abstract: An oral hygiene apparatus in the form of a fixture to provide a controllable pressurized water stream for cleansing the gums and teeth, especially in the interdental area, of a user. The hygiene apparatus may essentially comprise three parts including a water supply, an oral hygiene-ware and a water utility.

Abstract: Oral hygiene apparatus utilize the natural water and it pressure effectively performs oral hygiene functioning without electricity, batteries, mechanical pumps and motors. It could be a fixture in bathroom.

Abstract: Build-in and portable oral hygiene systems and devices are disclosed which systems and devices effectively function without electricity, batteries, mechanical pumps and motors. Build-in oral hygiene systems may utilize a single set of hot and cold water supply hoses and may be integrated with the faucet as a permanent sink apparatus while portable hygiene devices are manpowered and thus may be used at anytime and anywhere.

Abstract: Heat exchange inefficiencies found in round tube plate fin heat exchangers are eliminated in an aluminum heat exchanger that includes first and second headers (20), (22) and at least one flattened tube (24), (70) extending between the headers (20), (22). A plurality of generally parallel tube runs are defined and each has opposite edges. A plurality of plate fins (26), (50) are arranged in a stack and each has a plurality of open ended slots (34), one for each run of the tubes (24), (70). Each of the tube runs (24), (70) is nested within corresponding slots (26) and the fins (26), (50) with one of the edges (40) of the tube runs extending outwardly of the corresponding fin (26). The assembly is brazed together.

Abstract: Heat exchange inefficiencies found in round tube plate fin heat exchangers are eliminated in an aluminum heat exchanger that includes first and second headers (20), (22) and at least one flattened tube (24), (70) extending between the headers (20), (22). A plurality of generally parallel tube runs are defined and each has opposite edges. A plurality of plate fins (26), (50) are arranged in a stack and each has a plurality of open ended slots (34), one for each run of the tubes (24), (70). Each of the tube runs (24), (70) is nested within corresponding slots (26) and the fins (26), (50) with one of the edges (40) of the tube runs extending outwardly of the corresponding fin (34). The assembly is brazed together.

Abstract: Heat exchange inefficiencies found in round tube plate fin heat exchangers are eliminated in an aluminum heat exchanger that includes first and second headers (20), (22) and at least one flattened tube (24), (70) extending between the headers (20), (22). A plurality of generally parallel tube runs are defined and each has opposite edges. A plurality of plate fins (26), (50) are arranged in a stack and each has a plurality of open ended slots (34), one for each run of the tubes (24), (70). Each of the tube runs (24), (70) is nested within corresponding slots (26) and the fins (26), (50) with one of the edges (40) of the tube runs extending outwardly of the corresponding fin (26). The assembly is brazed together.

Abstract: A serpentine, slit fin (26) is provided for a heat sink device (10) used for cooling a electronic component (12) having a surface (14) that rejects heat. The heat sink (10) includes a plate (16) having first and second surfaces (18, 20), with the first surface (18) configured to receive heat from the surface (14) of the electronic component (12). The fin (26) is bonded to the second surface and includes a plurality of offset sidewall portions (48). In one form, a fan (22) is spaced above the second surface (20) to direct an impingement airflow (24) towards the second surface (20) substantially perpendicular to the second surface (20), and the serpentine, slit fin (26) underlies the fan (22) and is bonded to the second surface (20).

Abstract: Heat exchange inefficiencies found in round tube plate fin heat exchangers are eliminated in an aluminum heat exchanger that includes first and second headers (20), (22) and at least one flattened tube (24), (70) extending between the headers (20), (22). A plurality of generally parallel tube runs are defined and each has opposite edges. A plurality of plate fins (26), (50) are arranged in a stack and each has a plurality of open ended slots (34), one for each run of the tubes (24), (70). Each of the tube runs (24), (70) is nested within corresponding slots (26) and the fins (26), (50) with one of the edges (40) of the tube runs extending outwardly of the corresponding fin (26). The assembly is brazed together.