Patents by Inventor Wise Young

Wise Young has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220395623
    Abstract: Described herein are novel methods for fractionating and isolating platelets, platelet- and extracellular vesicle-derived growth factors, exosomes, globulins, fibrinogen and albumin, and methods of using the isolated platelets, platelet and extracellular vesicle-derived growth factors, exosomes, globulins, fibrinogen and albumin for regenerating tissue in a subject, treating fibrinogenemia or a clotting deficiency in a subject, treating ischemia and hypoxia, treating dry-eye syndrome, an orthopedic disorder, or a dental disorder in a subject. Also described herein are growth media for culturing mammalian (e g , human) cells.
    Type: Application
    Filed: November 25, 2020
    Publication date: December 15, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Wise Young, Dongming Sun
  • Publication number: 20220378840
    Abstract: Compositions, containers and kits for low temperature storage of a specified quantity of packed red blood cells (RBCs) include L-camitine, HES and blood plasma proteins. Methods of storing a packed RBC blood product, transfusing a packed RBC blood product into a subject, and treating anemia, ischemia, hypoxia, a hemoglobin disorder, or a hematopoietic disorder in a subject (e.g., a human) include the compositions, containers, kits and blood products.
    Type: Application
    Filed: November 25, 2020
    Publication date: December 1, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Wise Young, Dongming Sun, Iman Tadmori
  • Publication number: 20220175674
    Abstract: This invention relates to processes and products for packaging and shipping therapeutic cells for cell therapy.
    Type: Application
    Filed: May 12, 2020
    Publication date: June 9, 2022
    Applicants: Stemcyte Inc., Rutgers, The State University of New Jersey
    Inventors: Monica Chen, Richard Tonai, Wise Young, Dongming Sun, Jonas Wang
  • Publication number: 20220169979
    Abstract: This disclosure describes efficient methods for separating desired populations of cells, including Multilineage-Differentiating Stress-Enduring (MUSE) cells. Also described are the methods for isolating and enriching MUSE cells through a sorting, expanding, and re-sorting procedure. The enriched cells or cell populations can be used for treating cancer, repairing various tissues, and treating various degenerative or inherited diseases.
    Type: Application
    Filed: April 9, 2020
    Publication date: June 2, 2022
    Applicants: Rutgers, The State University of New Jersey, Life Science Institute, Inc.
    Inventors: Wise Young, Dongming Sun, Iman Tadmori, Zikuan Leng, Mari Dezawa
  • Patent number: 10493109
    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: December 3, 2019
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Dongming Sun, Wise Young
  • Patent number: 10400212
    Abstract: This invention concerns methods of packaging and shipping stem cells. Also disclosed are related package products.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: September 3, 2019
    Assignee: Stemcyte Inc.
    Inventors: Wise Young, Dongming Sun, Robert Fleischaker, Kam Sze Kent Tsang
  • Publication number: 20180273901
    Abstract: This invention concerns methods of packaging and shipping stem cells. Also disclosed are related package products.
    Type: Application
    Filed: April 23, 2018
    Publication date: September 27, 2018
    Applicant: Stemcyte Inc.
    Inventors: Wise Young, Dongming Sun, Robert Fleischaker, Kam Sze Kent Tsang
  • Publication number: 20180250344
    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.
    Type: Application
    Filed: October 12, 2017
    Publication date: September 6, 2018
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: DONGMING SUN, WISE YOUNG
  • Patent number: 9951309
    Abstract: This invention concerns methods of packaging and shipping stem cells. Also disclosed are related package products.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: April 24, 2018
    Assignee: Stemcyte Inc.
    Inventors: Wise Young, Dongming Sun, Robert Fleischaker, Kam Sze Kent Tsang
  • Publication number: 20150329827
    Abstract: The present invention, relates to novel methods of isolating and expanding pluripotent stem cells, including multi-lineage stress enduring (MUSE) cells.
    Type: Application
    Filed: December 23, 2013
    Publication date: November 19, 2015
    Inventors: Wise Young, Yi Ban, Dongming Sun, Mari Dezawa
  • Publication number: 20150231184
    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.
    Type: Application
    Filed: September 22, 2014
    Publication date: August 20, 2015
    Inventors: DONGMING SUN, WISE YOUNG
  • Patent number: 8852938
    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 7, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: DongMing Sun, Wise Young
  • Publication number: 20140227236
    Abstract: Disclosed are recombinant stem cells that are resistant to HIV infection. Also disclosed are their uses in treating AIDS.
    Type: Application
    Filed: April 18, 2014
    Publication date: August 14, 2014
    Applicant: StemCyte, Inc.
    Inventor: Wise Young
  • Publication number: 20140051165
    Abstract: This invention concerns methods of packaging and shipping stem cells. Also disclosed are related package products.
    Type: Application
    Filed: February 14, 2012
    Publication date: February 20, 2014
    Applicant: Stemcyte Inc.
    Inventors: Wise Young, Dongming Sun, Robert Fleischaker, Kam Sze Kent Tsang
  • Publication number: 20120034197
    Abstract: Disclosed are recombinant stem cells that are resistant to HIV infection. Also disclosed are their uses in treating AIDS.
    Type: Application
    Filed: April 6, 2010
    Publication date: February 9, 2012
    Applicant: STEMCYTE INC.
    Inventor: Wise Young
  • Publication number: 20100189696
    Abstract: The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 29, 2010
    Inventors: DongMing Sun, Wise Young
  • Patent number: 5200345
    Abstract: Tissue damage may be quantified, tissue type identified, neural activity monitored or blood hematocrit determined by measuring the difference between the total tissue sodium and potassium concentrations in the area in question. Comparison of these measurements with standard values permit evaluation of the amount of tissue damage in cells of the same type or the tissue type in non-necrotic cells. Evaluation over time of normal brain cells permit monitoring of neural activity. By directly and simultaneously measuring sodium and potassium ion concentrations, for example, a nuclear magnetic resonance spectrometer can image areas of different tissue type in differing colors. In this manner tumors and lesions can be clearly delineated. Measurement of total potassium concentration of a blood sample and the potassium concentration of the cell-free plasma will permit determination of cellular volume fraction (hematocrit).
    Type: Grant
    Filed: August 2, 1990
    Date of Patent: April 6, 1993
    Assignee: New York University
    Inventor: Wise Young
  • Patent number: 5143081
    Abstract: The behavioral tendencies of a system in which responses evoked by stimuli are measurable are determined by means of a method and apparatus for applying a train of paired stimuli to the system and measuring and analyzing the response. The first of each pair of stimuli (conditioning stimulus) is applied at randomly varying intensities and at a constant interval. The second of each pair of stimuli (test stimulus) is applied at a constant intensity and a randomly varying interval from its associated test stimulus. By appropriate analysis of the amplitude and latency of the evoked responses, important information about fatigue, refractory period, supernormal period, threshold and dynamical fluctuation can be determined.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: September 1, 1992
    Assignee: New York University
    Inventors: Wise Young, Kaoru Sakatani