Patents by Inventor Wlodzimierz Mandecki

Wlodzimierz Mandecki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically engineered enzymes and their conjugates for diagnostic assays
    Patent number: 5843634
    Abstract: This invention relates to genetically engineered enzymes, their ligand conjugates, their manufacture, and their use in qualitative or quantitative assays. A hybrid enzyme, such as an AP-epitope, has a foreign amino acid moiety (an epitope) inserted near the active site of the starting AP enzyme. The foreign amino acid moiety binds with an analyte, and, as a consequence of this binding, the enzymatic activity of the hybrid enzyme, AP-epitope, is modified. The changes in the enzymatic activity are dependent upon the presence, or the amount, of the analyte. In another embodiment, the hybrid enzyme consists of a cysteine introduced near the active site of an AP to give a hybrid enzyme. The cysteine on the hybrid enzyme serves as a point of conjugation of a ligand, such as theophylline, ferritin, thyroxine, or digoxigenin, to form the hybrid enzyme-ligand conjugate.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: December 1, 1998
    Assignee: Abbott Laboratories
    Inventors: Elaine M Brate, Catherine A. Brennan, Dominique P. Bridon, Keeve D. Jaffe, Grant A. Krafft, Wlodzimierz Mandecki, Steven C. March, John C. Russell, Vincent T. Yue
  • Methods for using CKS fusion proteins
    Patent number: 5322769
    Abstract: Improved methods for detecting antibodies in test samples. The improvement comprises uses CKS-fusion proteins specific for the antibodies in assays such as screening assays, competitive assays, confirmatory assays and immunodot assays. Test kits which contain these CKS-fusion proteins useful in such assays also are provided.
    Type: Grant
    Filed: June 23, 1992
    Date of Patent: June 21, 1994
    Assignee: Abbott Laboratories
    Inventors: Timothy J. Bolling, Wlodzimierz Mandecki, Sushil G. Devare, James M. Casey, Suresh M. Desai
  • CKS method of HCV protein synthesis
    Patent number: 5312737
    Abstract: Disclosed is a method of producing fusion proteins, particularly HCV fusion proteins, wherein one part of the fusion protein is formed from the bacterial protein CKS.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: May 17, 1994
    Assignee: Abbott Laboratories
    Inventors: Timothy J. Bolling, Wlodzimierz Mandecki
  • CKS method of protein synthesis
    Patent number: 5124255
    Abstract: Disclosed is a method of producing fusion proteins wherein one part of the fusion protein is formed from the bacterial protein CKS.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: June 23, 1992
    Assignee: Abbott Laboratories
    Inventors: Timothy J. Bolling, Wlodzimierz Mandecki