Patents by Inventor Wojciech J. Stec

Wojciech J. Stec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DERIVATIVES OF NUCLEOSIDE-5'-O-HYPOPHOSPHATES AND THEIR MONO- AND DITHIOHYPOPHOSPHATE ANALOGUES AND THE PROCESS FOR THE MANUFACTURE THEREOF
    Publication number: 20110015383
    Abstract: The subject of the invention includes derivatives of nucleoside-5?-O-hypophosphates and their mono- and dithiohypophosphate analogues, in particular 5?-O-[?,?-dialkyl-(?-thiohypophosphate)]-, 5?-O-[?,?-dialkyl-(?,?-dithiohypophosphate)]-, 5?-O-[?,?-dialkyl-(?,?-dithiohypophosphate)-, 5?-O-[?-alkyl-(?-thiohypophosphate)]-, 5?-O-[?-alkyl-(?, oc-dithiohypophosphate)]-, 5?-O-(a-thiohypophosphate)]- and 5?-O-(a,a-dithiohypophosphate)nucleosides.
    Type: Application
    Filed: July 1, 2008
    Publication date: January 20, 2011
    Inventors: Wojciech J. Stec, Damian W. Blaziak
  • 5' O [(N ACYL)AMIDOPHOSPHATE] AND 5' O [(N ACYL)AMIDOTHIOPHOSPHATE] AND 5' O [(N ACYL)AMIDODITHIOPHOSPHATE] AND 5' O [(N ACYL)AMIDOSELENOPHOSPHATE] DERIVATIVES OF NUCLEOSIDES AND PROCESSES FOR THE MANUFACTURE THEREOF
    Publication number: 20100137576
    Abstract: The subject of the invention includes 5?-O-[(N-acyl)amidophosphate]- and 5?-O-[(N-acyl)amidothiophosphate]- and 5?-O-[(N-acyl)amidodithiophosphate]- and 5?-O-[(N-acyl)amidoselenophosphate]- derivatives of nucleosides.
    Type: Application
    Filed: October 16, 2007
    Publication date: June 3, 2010
    Applicant: CENTRUM BADAN MILEKULARNYCHI MAKROMOLEKULARNYCH, P
    Inventors: Wojciech J. Stec, Janina Baraniak, Renata Kaczmarek, Ewa Wasilewska, Dariusz Korczynski, Katarzyna Pieta
  • Process for the synthesis of modified P-chiral nucleotide analogues
    Patent number: 6407223
    Abstract: The process of the instant invention is drawn to the synthesis of modified P-chiral nucleotide analogues in the form of pure diastereomers possessing preselected configuration at the P-atom. Oligonucleotides prepared by the method of the invention containing P-chiral compounds have enhanced hybridization and transporting properties.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: June 18, 2002
    Assignee: Polska Akademia Nauk Cenirum Badan Molekularnych i Makromlekularnych
    Inventors: Wojciech J. Stec, Lucyna A. Woźniak, Arkadiusz Chworoś, Jaroslaw Pyzowski
  • Compositions and methods for the synthesis of organophosphorus derivatives
    Patent number: 5936080
    Abstract: New organophosphorus mononucleoside derivatives, methods of their synthesis and methods for the synthesis of organophosphorus dinucleotide derivatives utilizing the organophosphorus mononucleosides are provided.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: August 10, 1999
    Assignees: Genta Incorporated, Polska Akademia Nauk
    Inventors: Wojciech J. Stec, Lucyna Wozniak
  • Oligonucleotides having R.sub.p and S.sub.p linkages at predetermined locations
    Patent number: 5883237
    Abstract: Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O-?1,3,2-dichalcogen-substituted-phospholane! synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O-?1,3,2-dichalcogen-substituted-phospholane! synthons, and P-chiral oligonucleotides and related P-chiral polymers.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: March 16, 1999
    Assignee: Polish Academy of Science
    Inventors: Wojciech J. Stec, Andrzej Grajkowski, Bogdan Uznanski
  • Method of making oligonucleotides and oligonucleotide analogs using phospholanes and enantiomerically resolved phospholane analogues
    Patent number: 5646267
    Abstract: Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons, and P-chiral oligonucleotides and related P-chiral polymers.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 8, 1997
    Assignee: Polish Academy of Sciences
    Inventors: Wojciech J. Stec, Andrzej Grajkowski, Bogdan Uznanski
  • Solid phase oligonucleotide synthesis using phospholane intermediates
    Patent number: 5512668
    Abstract: Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O- 1,3,2-dichalcogen-substituted-phospholane! synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O- 1,3,2-dichalcogen-substituted-phospholane! synthons, and P-chiral oligonucleotides and related P-chiral polymers.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: April 30, 1996
    Assignee: Polish Academy of Sciences
    Inventors: Wojciech J. Stec, Andrzej Grajkowski, Bogdan Uznanski
  • Method of synthesizing sulfurized oligonucleotide analogs
    Patent number: 5292875
    Abstract: A method for synthesizing sulfurized oligonucleotide analogs, such as phosphorothioate and phosphorodithioate analogs, is provided that employs a thiophosphorus compound, such as a thiophosphoric, dithiophosphoric, thiophosphinic, or dithiophosphinic acid disulfide or polysulfide, as a sulfurizing agent. The method of the invention may be used to sulfurize any phosphorous(III)containing intermediate. Preferably, the method is practiced on a commercial DNA synthesizer using phosophoramidite and/or phosphorthioamidite intermediates.
    Type: Grant
    Filed: August 27, 1993
    Date of Patent: March 8, 1994
    Assignee: Lynx Therapeutics, Inc.
    Inventors: Wojciech J. Stec, Bogdan Uznanski, B. John Bergot, Bernard L. Hirschbein, Karen L. Fearson
  • Method of synethesizing sulfurized oligonucleotide analogs
    Patent number: 5151510
    Abstract: A method for synthesizing sulfurized oligonucleotide analogs, such as phosphorothioate and phosphorodithioate analogs, is provided that employs a thiophosphorus compound, such as a thiophosphoric, dithiophosphoric, thiophosphinic, or dithiophosphinic acid disulfide or polysulfide, as a sulfurizing agent. The method of the invention may be used to sulfurize any phosphorous(III)-containing intermediate. Preferably, the method is practiced on a commercial DNA synthesizer using phosphoramidite and/or phosphorthioamidite intermediates.
    Type: Grant
    Filed: April 20, 1990
    Date of Patent: September 29, 1992
    Assignee: Applied Biosystems, Inc.
    Inventors: Wojciech J. Stec, Bogdan Uznanski, B. John Bergot, Bernard L. Hirschbein, Karen L. Fearon
  • Process for the production of 1,3,2-oxazaphosphorinanes
    Patent number: 4908464
    Abstract: Process for production of derivatives of 1,3,2-oxazaphosphorinane of general formula 1, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atom or 2-halogenoalkyl group, and R.sub.1 and R.sub.2 are not at the same time hydrogen atoms, and X represents halogen atom is based, according to the invention, on the reduction of the respective 3-halogenoacyl derivatives of 1,3,2-oxazaphosphorinane of general formula 2, ##STR2## wherein the substituents have the above given meaning. The reduction is accomplished with the use of sodium borohydride in the presence of boron trifluoride etherate.Derivatives that are prepared by the procedure described here demonstrate antitumor activity.
    Type: Grant
    Filed: June 9, 1988
    Date of Patent: March 13, 1990
    Assignees: Instytut Przemyslu Farmaceutycznego, Centrum Baden Molekularnych i Makromolekularnych -PAN, Instytut Immunologii i Terapii Doswiadczalnej -PAN
    Inventors: Wojciech J. Stec, Czeslaw Radzikowski, Wieslaw Szelejewski, Ryszard Kinas, Konrad Misiura, Grzegorz Grynkiewicz, Jacek Grodner, Halina Kusnierczyk, Andrzej Kutner, Slawomira Pilichowska