Patents by Inventor Wolf-Dieter Fessner

Wolf-Dieter Fessner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fusion proteins comprising an aldolase enzyme joined to a maltose binding protein
    Patent number: 10683493
    Abstract: The present invention refers to an enzyme consisting of a fusion protein particularly useful as shown through-out the present invention for carrying out the carbon-carbon bond-forming reaction known as the aldol Reaction, preferably for carrying out an aldol reaction by using aldehydes as substrates and preferably pyruvate or a salt thereof, for producing hydroxyketoacids. Said enzyme is made by binding an aldolase to a maltose binding protein. The enzymes display full activity under “highly denaturing” substrate loadings (aldehydes, >1 M).
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: June 16, 2020
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS, TECHNICAL UNIVERSITY OF DARMSTADT, SUSTAINABLE MOMENTUM, S.L.
    Inventors: Pedro Clapés Saborit, Karel Hernández Sánchez, Jesús Joglar Tamargo, Jordi Bujons Vilás, Wolf-Dieter Fessner, Pablo Domínguez De María
  • FRUCTOSE-6-PHOSPHATE ALDOLASE VARIANTS FOR ALDOL CARBOLIGATIONS
    Publication number: 20200165640
    Abstract: The invention provides new and alternative fructose-6-phosphate aldolase (FSA) variants which enable the production of optically active building blocks with high chemoselectivity and stereoselectivity using aldehydes as starting material in aldol carboligation reactions, while avoiding the by-product formation and subsequent reactions.
    Type: Application
    Filed: April 5, 2018
    Publication date: May 28, 2020
    Inventors: Pedro CLAPÉS SABORIT, Jesus JOGLAR TAMARGO, Jorge BUJONS VILAS, Raque! ROLDAN GARCIA, Wolf-Dieter FESSNER, Sebastian JUNKER, Pabio DOMINGUEZ DE MARIA
  • FUSION PROTEINS COMPRISING AN ALDOLASE ENZYME JOINED TO A MALTOSE BINDING PROTEIN
    Publication number: 20190194638
    Abstract: The present invention refers to an enzyme consisting of a fusion protein particularly useful as shown through-out the present invention for carrying out the carbon-carbon bond-forming reaction known as the aldol Reaction, preferably for carrying out an aldol reaction by using aldehydes as substrates and preferably pyruvate or a salt thereof, for producing hydroxyketoacids. Said enzyme is made by binding an aldolase to a maltose binding protein. The enzymes display full activity under “highly denaturing” substrate loadings (aldehydes, >1 M).
    Type: Application
    Filed: May 17, 2017
    Publication date: June 27, 2019
    Inventors: Pedro CLAPÉS SABORIT, Karel HERNÁNDEZ SÁNCHEZ, Jesús JOGLAR TAMARGO, Jordi BUJONS VILÁS, Wolf-Dieter FESSNER, Pablo DOMÍNGUEZ DE MARÍA
  • Enzymatic process for the production of dihydroxyacetone phosphate from glycerophosphate and its use in enzymatic aldol additions
    Patent number: 5683897
    Abstract: The invention concerns a process for the production of dihydroxyacetone phosphate (DHAP) by enzymatic oxidation of glycerophosphate in the presence of glycerophosphate oxidase and an H.sub.2 O.sub.2 -decomposing enzyme such as catalase and also concerns the conversion of DHAP formed in situ in a coupled enzymatic aldol addition to produce carbohydrates or corresponding derivatives.
    Type: Grant
    Filed: August 8, 1995
    Date of Patent: November 4, 1997
    Assignee: Boehringer Mannheim GmbH
    Inventor: Wolf-Dieter Fessner