Abstract: It is provided a measuring cartridge (1) for measuring at least one constituent of a liquid sample, in particular blood, and for performing quality control, the cartridge comprising: a casing (3) insertable into a reception opening (51) of a measuring instrument (50), the casing (3) at least partly surrounding an inner space (5); wherein the inner space contains: a measurement cell (7) comprising a reception space (9) for the sample and at least one sensor area (11) with which the sample is in contact when loaded into the reception space (9); plural quality control containers (13a,13b,13c) for respectively holding different quality control solutions (15a,15b,15c); a solution routing system (17) adapted to selectively route one of the quality control solutions (15a,15b,15c) from the respective quality control container (13a,13b,13c) into the reception space (9) of the measurement cell (7).

Abstract: It is provided an arrangement and a method for measuring at least one constituent of a liquid sample, in particular comprising serum, plasma and/or urine, the arrangement comprising: a first portion adapted to partly delimit a reception space for the sample at a first side and comprising at least one measurement area; a second portion comprising: a reception space wall section, the second portion being coupled to the first portion such that the reception space wall section partly delimits the reception space at a second side; and a sample input cup delimiting a sample input region into which the sample is fillable, wherein the sample input region is in fluid communication with the reception space, wherein the reception space wall section and at least a portion of the sample input cup are integrally formed.

Abstract: It is provided a measuring cartridge (1) for measuring at least one constituent of a liquid sample, in particular blood, and for performing quality control, the cartridge comprising: a casing (3) insertable into a reception opening (51) of a measuring instrument (50), the casing (3) at least partly surrounding an inner space (5); wherein the inner space contains: a measurement cell (7) comprising a reception space (9) for the sample and at least one sensor area (11) with which the sample is in contact when loaded into the reception space (9); plural quality control containers (13a,13b,13c) for respectively holding different quality control solutions (15a,15b,15c); a solution routing system (17) adapted to selectively route one of the quality control solutions (15a,15b,15c) from the respective quality control container (13a,13b,13c) into the reception space (9) of the measurement cell (7).

Abstract: In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.

Abstract: In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.

Abstract: In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.

Abstract: In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.

Abstract: An electrochemical measuring device comprises an essentially planar sensor substrate with at least one electrochemical sensor, and a cover part in which a tunnel-shaped measuring channel is formed. At least one guiding groove is provided in parallel with the measuring channel. A sealing element which is positioned between the sensor substrate and the cover part to seal the measuring channel is provided with guiding bodies along its length, at least one of which guiding bodies projects into the guiding groove of the cover part. The sealing element is provided with narrow sealing lips bounding the measuring channel. Each short side of the sealing element has a guiding body projecting into recesses in the sensor substrate. The guiding bodies are disposed on that side of a sealing plane defined by the sealing lips, which faces away from the cover part.

Abstract: In a process for mixing two initial solutions to produce a working solution with an accurately defined mixing ratio, the two initial solutions are coarsely mixed in a first step, having a mixing ratio lying within a given range, and the value of an internal parameter of the working solution is determined in a second step. The values of this internal parameter are known and differ significantly for the two initial solutions. Then the accurate mixing ratio of the working solution is determined from the measured value of the internal parameter in a third step.

Abstract: A fluid-tight connection of capillary channels in components which are detachable from each other is established with the use of a sealing element. In order to compensate for slight deviations between the channel axes during the coupling of the components without creating any dead spaces, the sealing element is configured as a piece of flexible tubing adapting to the course of the capillary channels during component coupling, and a mounting element anchored in one of the components.

Abstract: In order to avoid dead volumes in a valve for control of a branch line departing from the main line in a valve chamber located in a valve housing, the valve chamber contains an elastomer part provided with a main channel and a branch channel departing from it, and the two ends of the main channel are sealingly connected with the main lines. The free end of the branch channel is sealingly connected with the branch line, and further that a valve lifter be provided in the valve housing, which acts on the branch channel in the branch-off area directly adjacent to the main channel of the elastomer part, thus reducing the cross-section of the branch channel, which is held in place by a counterpiece in the valve housing.

Abstract: An electrode arrangement includes at least one potentiometric measuring electrode located in a sample channel, a reference electrode located in a branch line, and a suction pump downstream of the diaphragmless entrance opening of the branch line into the sample channel the reference electrode being an ion-sensitive, i.e., preferably chloride-sensitive, membrane electrode.