Patents by Inventor Wolf Frommer

Wolf Frommer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRP/HIS exchange and kynurenin induced TRP transport
    Patent number: 8071744
    Abstract: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: December 6, 2011
    Assignees: Carnegie Institution of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thijs Kaper, Michael Platten, Lawrence Steinman, Wolf Frommer
  • TRP/HIS EXCHANGE AND KYNURENIN INDUCED TRP TRANSPORT
    Publication number: 20110223657
    Abstract: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
    Type: Application
    Filed: April 28, 2011
    Publication date: September 15, 2011
    Inventors: Thijs Kaper, Michael Platten, Lawrence Steinman, Wolf Frommer
  • Trp/his exchange and kynurenine induced Trp transport
    Patent number: 7935494
    Abstract: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: May 3, 2011
    Assignees: Carnegie Institution of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thijs Kaper, Michael Platten, Lawrence Steinman, Wolf Frommer
  • TRP/HIS Exchange and Kynurenine Induced TRP Transport
    Publication number: 20080227140
    Abstract: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
    Type: Application
    Filed: February 29, 2008
    Publication date: September 18, 2008
    Inventors: Thijs Kaper, Michael Platten, Lawrence Steinman, Wolf Frommer
  • Neurotransmitter Sensors and Methods of Using the Same
    Publication number: 20080019920
    Abstract: Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding neurotransmitter. Such biosensors are useful for the detection of neurotransmitter concentrations in vivo and in culture.
    Type: Application
    Filed: October 14, 2005
    Publication date: January 24, 2008
    Applicant: CARNEGIE INSTITUTION OF WASHINGTON
    Inventors: Sakiko Okumoto, Loren Looger, Wolf Frommer