Abstract: The invention relates to an apparatus for the chromatographic separation of a substance mixture in liquid form, comprising a stationary phase, wherein the stationary phase is configured in particular as a plate or plate-shaped body, consisting in particular of a porous solid, characterised in that the apparatus comprises at least one feed device for feeding a substance mixture, wherein the feed device comprises a plurality of feed openings and a plurality of feed lines and the feed openings are in particular disposed in one plane so that the length of the feed lines from a collecting feed line to at least a part of the plurality of feed openings is substantially the same.

Abstract: The present invention is directed to methods of isolating and purifying protein from a bioreactor process. The invention relates to employing a protein phase separation methodology to isolate or purify protein product in the forms of solid, semi-solid, or suspension during a protein manufacturing purification process as a stable storage intermediate. This approach is designed to allow the isolated protein product (purified or partially purified) to be stored over an extended period of time prior to further protein purification steps.

Abstract: A process for inactivating the biological activity of DNA, especially recombinant DNA, is disclosed. The process includes the step of heating the DNA at 60.degree. to 100.degree. C. in the presence of an acid other than percarboxylic acid at a concentration of at least 0.2 mM and a pH value of maximum 4, preferably 3.