Patents by Inventor Wolfgang Brill

Wolfgang Brill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
    Patent number: 7632854
    Abstract: Compounds which are indazole derivatives and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them, as well as combinatorial libraries of indazole derivatives, as set forth in the specification, are disclosed; these compounds or compositions may be useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
    Type: Grant
    Filed: November 17, 2004
    Date of Patent: December 15, 2009
    Assignee: Pfizer Italia S.r.l.
    Inventors: Katia Martina, Wolfgang Brill
  • Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
    Publication number: 20060106083
    Abstract: Compounds which are indazole derivatives and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them, as well as combinatorial libraries of indazole derivatives, as set forth in the specification, are disclosed; these compounds or compositions may be useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
    Type: Application
    Filed: November 17, 2004
    Publication date: May 18, 2006
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Katia Martina, Wolfgang Brill
  • Inhibition of reverse transcriptase by phosphorodithioates
    Patent number: 5695979
    Abstract: The present invention describes a method for the inhibition of reverse transcriptase by contacting said reverse transcriptase with oligonucleotides having have at least one phosphorodithioate internucleotide linkage of the formula ##STR1## within the phosphorus backbone of the oligonucleotide.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: December 9, 1997
    Assignee: Competitive Technologies, Inc.
    Inventors: Marvin H. Caruthers, William S. Marshall, Wolfgang Brill, John Nielsen
  • Polynucleotide phosphorodithioate
    Patent number: 5453496
    Abstract: Oligonucleotides having at least one phosphorodithioate internucleotide linkage. Phosphorodithioate oligonucleotides exhibit stronger antiviral activity than the corresponding phoshorothioate derivatives.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: September 26, 1995
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, William S. Marshall, Wolfgang Brill, John Nielsen
  • Nucleoside thiophosphoramidites
    Patent number: 5218103
    Abstract: The present invention relates to new and useful nucleside thiophosphoramidite, polynucleotide dithioate phosphoramidite and polynucleotide phosphorothioamidate phosphoramidite compounds as well as the process whereby these compounds can be used for synthesizing new monoucleotides and polynucleotides having phosphorodithioate, phosphorothioamidate, phosphorothiotriesters and phosphorothioate internucleotide linkages.
    Type: Grant
    Filed: January 22, 1991
    Date of Patent: June 8, 1993
    Assignee: University Patents, Inc.
    Inventors: Marvin H. Caruthers, Yun-Xi Ma, Eric K. Yau, John Nielsen, Wolfgang Brill