Patents by Inventor Wolfgang Deger

Wolfgang Deger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of immobilized and activity-stabilized complexes of LHRH antagonists
    Patent number: 6054555
    Abstract: In this invention, a release-delaying system is to be developed for LHRH antagonists, in particular for cetrorelix, which allows the active compound to be released in a controlled manner over several weeks by complexation with suitable biophilic carriers. The acidic polyamino acids polyglutamic acid and polyaspartic acid were selected for complexation with cetrorelix. The cetrorelix polyamino acid complexes are prepared from aqueous solutions by combination of the solutions and precipitation of the complexes, which are subsequently centrifuged off and dried over P.sub.2 O.sub.5 in vacuo. If complexes having a defined composition are to be obtained, lyophilization proves to be a suitable method. The cetrorelix-carboxylic acid complexes were also prepared from the aqueous solutions. In the random liberation system, the acidic polyamino acids poly-Glu and poly-Asp showed good release-delaying properties as a function of the hydrophobicity and the molecular mass of the polyamino acid.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: April 25, 2000
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Jurgen Engel, Wolfgang Deger, Thomas Reissmann, Gunter Losse, Wolfgang Naumann, Sandra Murgas
  • Immobilized and activity-stabilized complexes of LHRH antagonists and processes for their preparation
    Patent number: 6022860
    Abstract: In this invention, a release-delaying system is to be developed for LHRH antagonists, in particular for cetrorelix, which allows the active compound to be released in a controlled manner over several weeks by complexation with suitable biophilic carriers.The acidic polyamino acids polyglutamic acid and polyaspartic acid were selected for complexation with cetrorelix. The cetrorelix polyamino acid complexes are prepared from aqueous solutions by combination of the solutions and precipitation of the complexes, which are subsequently centrifuged off and dried over P.sub.2 O.sub.5 in vacuo. If complexes having a defined composition are to be obtained, lyophilization proves to be a suitable method. The cetrorelix-carboxylic acid complexes were also prepared from the aqueous solutions.In the random liberation system, the acidic polyamino acids poly-Glu and poly-Asp showed good release-delaying properties as a function of the hydrophobicity and the molecular mass of the polyamino acid.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: February 8, 2000
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Jurgen Engel, Wolfgang Deger, Thomas Reissmann, Gunter Losse, Wolfgang Naumann, Sandra Murgas
  • Container for injectable mesna solutions
    Patent number: 5834520
    Abstract: Injectable mesna solutions having a pH value higher than 7.5. The solutions have increased storage stability.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: November 10, 1998
    Assignee: ASTA-Medica Aktiengesellschaft
    Inventors: Jurgen Engel, Elisabeth Wolf-Heuss, Wolfgang Deger, Giancarlo Camuglia, Dieter Sauerbier
  • Injectable mesna solutions
    Patent number: 5728738
    Abstract: Injectable mesna solutions having a pH value higher than 7.5. The solutions have increased storage stability.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 17, 1998
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Jurgen Engel, Elisabeth Wolf-Heuss, Wolfgang Deger, Giancarlo Camuglia, Dieter Sauerbier
  • Injectable mesna solutions
    Patent number: 5696172
    Abstract: Injectable mesna solutions having a pH value higher than 7.5. The solutions have increased storage stability.
    Type: Grant
    Filed: April 23, 1996
    Date of Patent: December 9, 1997
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Jurgen Engel, Elisabeth Wolf-Heuss, Wolfgang Deger, Giancarlo Camuglia, Dieter Sauerbier