Abstract: The present invention relates to adsorption membranes comprising microporous polymer membranes in which adsorbent particles are incorporated. Furthermore, the present invention relates to a method of producing the inventive adsorption membranes as well as devices which comprise the inventive adsorption membranes.

Abstract: The invention relates to a method for purifying and/or isolating high-molecular compounds, such as high-molecular proteins or protein-type compounds, contained in a solution or a suspension, by means of affinity chromatography using membranes containing metal ions.

Abstract: The present invention relates to adsorption membranes, comprising microporous polymer membranes into which are incorporated porous silicon dioxide particles modified with hydrocarbon ligands having 2 to 24 carbon atoms as adsorbent particles. Furthermore, the present invention relates to a method of producing the inventive adsorption membranes as well as devices which comprise the inventive adsorption membranes.

Abstract: Membrane holder for membrane adsorber chromatography comprising a housing body (12) with a reception space for at least one layer of adsorber membranes (22) and at least one first housing cap (34) for closing a first reception space opening, which can be fixed to the housing body (12), a liquid stream being introducible via first liquid guide means (36) through the first housing cap (34) and the first reception opening into the reception opening, so that it passes through the adsorber membranes (22) and flows away through a second reception space opening. The first housing cap (34) can be screwed as a first union nut onto the housing body (12) and a first brace element (24), which can be clamped between the first cap (34) and the housing body (12) via a flange (32) extending beyond the first reception space opening, can be fixed leaktightly in a basket-like insert (14) with a liquid-tight wall and a perforated bottom (18), which is used to receive the adsorber membranes (22).

Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.

Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.

Abstract: The invention describes a membrane and a method of making and using the same, the membrane being made from a microporous membrane body with an affinity ligand capable of interacting with at least one type of biomolecule found in a fluid, whereby the membrane body may be stored in a dried state yet retain the activity of the affinity ligand.

Abstract: There is disclosed a device for the simultaneous separation of particles and target substances from liquid feeds by adsorption membranes having particle-passing apertures therein.

Abstract: The present invention relates to adsorption membranes, comprising microporous polymer membranes into which are incorporated porous silicon dioxide particles modified with hydrocarbon ligands having 2 to 24 carbon atoms as adsorbent particles. Furthermore, the present invention relates to a method of producing the inventive adsorption membranes as well as devices which comprise the inventive adsorption membranes.

Abstract: The present invention relates to adsorption membranes comprising microporous polymer membranes in which adsorbent particles are incorporated. Furthermore, the present invention relates to a method of producing the inventive adsorption membranes as well as devices which comprise the inventive adsorption membranes.

Abstract: The present invention relates to a process which can be carried out continuously for the adsorption separation of substances in liquid media, in which process a flat adsorbent is loaded with an adsorbate by contacting the adsorbate-containing medium with the entire adsorbing outer surface of the adsorbent without forced flow through, and to an apparatus for carrying out the inventive process.

Abstract: The abstract discloses a method for preparing supports for the assay of chemical or biological substances, consisting in preparing N different supports, each being homogeneous for a type of reaction, then in mutually combining, according to a predetermined arrangement, all or part of the said homogenous N supports to constitute assay supports having each an ordered set of reaction zones of N different types or less. The invention also concerns the assay supports prepared by this method and their use in processes of immunological hybridisation assays.

Abstract: An adsorptive separation device is disclosed having at least one spiral wound adsorption membrane situated around the periphery of a core mandrel wherein the flow is radial from a feed plenum situated between the core mandrel and the membrane, through the membrane to a permeate plenum located between the membrane and a housing for both the core mandrel and the spiral wound membrane. An array of such separation devices is also disclosed showing connections in parallel, in series, in both parallel and in series and in tandem.

Abstract: Adsorptive separation is performed on liquid media by directing the media containing a target substance through an adsorber stage A whereby the target substance is adsorbed; in the last phase of loading stage A and prior to breakthrough of the target substance in the stage A permeate, the stage A permeate is directed to a second adsorber stage B. Upon completion of the stage A loading, the target substance from stage A is eluted with buffer solution, which buffer solution is introduced to stage B, and liquid medium is directed to the preloaded stage A, while stage A is eluted so as both recover the target substance and regenerate the adsorptive capacity of stage A.

Abstract: There is disclosed a membrane process for the purification of nucleic acids in aqueous solutions whereby a lasting reduction of endotoxin content is achieved. The process is suitable for small or large volumes and can be carried out quickly and with simple apparatus.

Abstract: A filtration unit for the separation of substances from liquids utilizes a rotatable cylindrical module with a permeable wall disposed within a housing. A filter element which has at least one band of microporous membrane adsorber having a specific adsorption affinity for the substances to be separated is disposed within the cylindrical module so that the membrane absorber is abutted to the cylindrical module. The filter element encircles the feed inlet and can be in the form of an endless loop. A permeate plenum lies between the cylindrical module and the housing. The cylindrical module includes a liquid impermeable end cap which is provided with a coupling member adapted for connection to a drive of variable rotational speed.

Abstract: A method of separating albumin from serum by ion exchange chromatography with membrane adsorbers characterized by high productivity and yields of high purity albumin. The separation of the albumin is carried out on highly basic anion exchange membranes and on highly acidic cation exchange membranes. The albumin fraction can be eluted from the anion exchange membrane such that it can be fed directly to the cation exchange membrane without any special conditioning and the albumin can be extracted therefrom as an end product.

Abstract: A process for cross-linking a cellulose hydrate membrane by use of a water-soluble diepoxide in an alkaline solution. The membrane so produced is highly resistant to attack by alkalis, acids and cellulases, and is readily regenerable by alkaline cleaning.

Abstract: A dead-end filtration unit without a housing comprising at least one filter cassette, each cassette comprising a plurality of laminar sections of porous adsorptive membrane, which have been rendered fluid-impermeable on their peripheries, the cassettes being sealingly compressed between two filter retainers fitted with feed inlet and permeate outlet and wherein the laminar sections are made of the same or different membrane adsorber types.

Abstract: Fabrication of the surface-grafted microporous membranes by coating the membrane with an N-halogenated compound, followed by grafting with an unsaturated monomer and sodium dithionite in a primarily aqueous solution that may contain an organic halogen compound selected from carbon tetrachloride and trichloroacetic acid. The coating may be formed in situ and may be cross-linked.